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N N Belyaev

Publications and source records attributed to N N Belyaev.

2 recordsLinked to original sources
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Bronchospasm mechanisms in experimental microbial sensitization. II. Pathochemical stage.

The pathochemical mechanisms of bronchospasm have been studied using various type of experimental allergies to microbial antigens. It was established that in guinea pigs with type I allergies isolated lung bronchospasm was mediated by histamine and SRS-A. Bronchial response to immune complexes type III were produced by the activation of complement with subsequent degranulation of mast cells and histamine release. Type IV hypersensitivity (lymphokine-mediated bronchospasm) was manifested without histamine, acetylcholine and mast cell involvement. The response to lymphokine was blocked by atropine. The spasmogenic y lymphokines are large molecular thermolabile substances.

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PubMedDate not supplied

The mechanisms of bronchospasm in experimental microbial sensitization. I. Immunological stage.

Immune mechanisms of smooth muscle spastic bronchial reactions were reproduced and studied in isolated guinea pig lungs and found to develop type I, III and IV allergic reactions at sensitization to brucella and staphylococcus. Type I reactions were reproduced in animal lungs with immediate hypersensitivity to soluble microbial antigens. Type III reactions were obtained by transfusion of soluble immune complexes containing microbial antigens into isolated lungs Bronchospastic reactions arose only in the presence of the complement. Antibodies responsible for bronchospasm belonged to the IgG class. Type IV reactions were produced in vitro using supernatants obtained by incubation of lymphoid cells isolated from animals with delayed hypersensitivity with homologic microbial antigens. The supernatants possessed bronchospastic action.

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