Bronchospasm mechanisms in experimental microbial sensitization. II. Pathochemical stage.

N N Belyaev; G S Sukhodoeva; N D Beklemishev

PubMed · 6206708

Bronchospasm mechanisms in experimental microbial sensitization. II. Pathochemical stage.

N N Belyaev·G S Sukhodoeva·N D Beklemishev

Abstract

The pathochemical mechanisms of bronchospasm have been studied using various type of experimental allergies to microbial antigens. It was established that in guinea pigs with type I allergies isolated lung bronchospasm was mediated by histamine and SRS-A. Bronchial response to immune complexes type III were produced by the activation of complement with subsequent degranulation of mast cells and histamine release. Type IV hypersensitivity (lymphokine-mediated bronchospasm) was manifested without histamine, acetylcholine and mast cell involvement. The response to lymphokine was blocked by atropine. The spasmogenic y lymphokines are large molecular thermolabile substances.

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Allergens Animals Antigens, Bacterial Atropine Autacoids Bronchi Bronchial Spasm Complement Activation Diphenhydramine Guinea Pigs Histamine Release Hypersensitivity Lymphokines Mast Cells Muscle Contraction Rats Journal Article

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N N Belyaev, G S Sukhodoeva, N D Beklemishev. Bronchospasm mechanisms in experimental microbial sensitization. II. Pathochemical stage.. https://pubmed.ncbi.nlm.nih.gov/6206708/

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