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N N Firsov

Publications and source records attributed to N N Firsov.

40 records · Page 3Linked to original sources
PubMedDate not supplied

[Effect of x-ray contrast substances in vitro on blood rheological properties].

It has been demonstrated that the radiographic contrast substances (RCS) having a high protein-binding capability, bilignost and endocystobil, exert the most pronounced effects on blood rheological properties, which manifests in an increase in blood fluidity and hydrodynamic strength of aggregates. A reverse, correlation was found between the degree of red cell aggregation and red cell binding with the RCS. The diatrizoate derivatives were shown to have the least significant effects on the rheological properties of the blood.

Blood Viscosity↗
PubMedDate not supplied

[The effect of x-ray contrast agents on the rheological properties of the blood].

The effects of X-ray contrast agents on human blood rheology were investigated. The main cause of rheological effects of X-ray contrast media is their action on the structure and function of erythrocytes. There was a relationship between the physicochemical properties and the mechanism of action. The major active factor is the high osmolality of X-ray contrast media solutions. Lipid solubility, specific features of molecular structures and the composition of a dosage form played a definite role.

Adolescent↗
PubMedDate not supplied

[The effect of cerebrocrast on erythrocyte function].

The new calcium antagonist cerebrocrast intravenously infused in a dose of 0.4 micrograms.kg-1.min-1 during 15 min prevented erythrocyte deformability disturbances at the end of cerebral ischemia in rats, which was induced by carotid artery occlusion during 30 min. The agents also prevented the deformability 1 hour after the onset of recirculation. Cerebrocrast reduced spontaneous erythrocyte aggregation, the strength of erythrocytic aggregates, and hemoglobin affinity for oxygen. The latter effect was associated with the drug-induced increase in erythrocytic 2,3-diphosphoglycerate levels.

Animals↗