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Biomedical subjects

N Palestini

Publications and source records attributed to N Palestini.

At least 37 records · Page 2Linked to original sources

[Analysis of 101,379 cases hospitalized for calculi of the bile dusts in the Region of Piedmont].

In a study from hospitals in Piemonte (Italy) were identified (from 1976 to 1981) 101,379 recovery for cholelitiasis. Among this group we have examined some factors like sex, age, residence, surgical procedures, etc. It is concluded that there is a continuous decreased in cholecistectomy rate and that can be explained by a simultaneous rise of new instrumental and farmacological procedures in the treatment of this pathology.

Adult↗

[Surgical treatment of functional tumors of the adrenal gland].

The authors evaluated and operated 40 cases of Cushing's syndrome, 8 cases of Conn's syndrome and 19 cases of phaeochromocytoma. The diagnosis was frequently delayed due to inadequate hormonal analysis. Cancer of the adrenal gland was observed in 17% of cases of Cushing's syndrome, while all cases of Conn's syndrome corresponded to an adenoma. There was a female predominance for both Cushing's syndrome and Conn's syndrome. Four malignant lesions were observed in the series of 19 tumours of the adrenal medulla (21% of cases). CT scan was found to be the most accurate of modern diagnostic techniques and was able to define the site and the dimensions of the adrenal tumour. Arteriography was particularly useful in cases with large, highly vascular tumours. The preferred surgical approach was lumbotomy, less frequently laparotomy, and, in cases of invasive tumour, thoraco-phreno-laparotomy. Removal of the tumour by adrenalectomy led to resolution of the symptoms and, in benign cases, complete cure.

Adrenal Gland Neoplasms↗

[Clinical study and surgical treatment of primary hyperparathyroidism].

A series of 26 patients with primary hyperparathyroidism surgically treated between 1970 and 1985 was reviewed to examine the clinical approach, the operative procedure and the results of surgical treatment. The study pointed out the reliability of PTH determination to confirm the diagnosis and the absence of efficacious diagnostic techniques for the preoperative localisation of the responsible lesion(s). Long term results were re-evaluated in 15 cases (58%), after a postoperative interval ranging from 1 to 13 years. The follow-up demonstrated a complete recovery in 12 patients, the persistence of a borderline symptomatology in 2, the relapse in one case.

Female↗

[Transduodenal papillotomy and divulsion of the papilla in the treatment of benign obstructions of the common bile duct (retrospective analysis of 186 cases)].

An analysis is presented of 186 cases of biliary benign obstruction, treated with transduodenal sphincterotomy or dilatation-divulsion of the papilla of Vater. The morbidity and mortality rates due to specific complications were 5.4% and 1.6% respectively. No cases of post-operative pancreatitis were observed. Long-term results were re-evaluated in 46 patients after a mean post-operative interval of 18 years. The follow-up demonstrated that the result was completely satisfactory in 70% of cases; fair in 17%, with gastroenterological symptoms not likely related to the biliary disease; poor in 13%, with residual stones or stenosis of the sphincter of Oddi.

Adolescent↗

Mortality, morbidity and long-term results in surgically treated hyperthyroid patients. Review of 597 cases.

An analysis is presented of 597 cases of Graves' disease or toxic multinodular goitre surgically treated in 1956-1980. The mortality rate was only 0.2%. The incidence of postoperative haemorrhage was 0.2%, damage to the recurrent laryngeal nerve 3.2%, postoperative thyrotoxic crisis 1.7%, acute hypoparathyroidism 2.2% and acute postoperative respiratory failure due to tracheomalacia 0.5%. Early complications were significantly more common among the patients with Grave's disease than in the multinodular goitre group. Thyroid function was re-evaluated in 116 patients after a mean postoperative interval of 9 years. Hyperthyroidism had recurred in ten of them and six were hypothyroid (8.6 and 5.2%). The evolution of the thyroid functional status was not significantly related to the pathology or to the sex or age of the patients.

Adolescent↗

[Intra- and postoperative complications in surgery of the thyroid gland].

The authors studied the inter- and postoperative complications arising in a series of 690 consecutive interventions on thyroid. The results showed a cipher mortality and a 3% aggregate morbidity. In 0.9% of cases, compressive hematomata in the thyroid loggia, collapse of the tracheal wall due to tracheomalacia or bilateral paralysis of the vocal cords determined an acute respiratory stoppage. 1.4% of the treated patients suffered from alterations in the motility of the vocal cords, ascribable to damage of the recurrent nerves. 0.9% of cases showed a postoperative parathyroid insufficiency, the nature of which, however, was always temporary. The incidence of complications, in the whole, resulted significantly higher in the patients undergoing iterative surgery, in respect of those operated on the first time.

Acute Disease↗

[Lung-term results in patients operated for benign diseases of the common bile ducts].

The remote results obtained in the treatment of the benign diseases of the main biliary duct were appraised on a specimen of 47 people operated on at the Surgical Department of the Turin University between 1960 and 1970, subjected to a checking visit at a distance from operation ranging from 12 up to 22 years. The investigation confirmed the impression that in biliary surgery some eventual failures can reach the clinical evidence after many years from operation, and allowed to demonstrate percentages of satisfactory, unsatisfactory and bad results as high as 80,8%, 8,5% and 10,6%, respectively.

Adolescent↗

[Echocardiographic findings in dystrophia myotonica (Steinert's disease)].

Ten patients with myotonic dystrophy have been studied by M-mode and 2-dimensional echocardiography. Six patients had echocardiographic abnormalities: mitral valve prolapse, hypertrophy of the papillary muscles (2 cases); impaired regional left ventricular relaxation, probably due to "cardiac myotonia" (4 patients); and dilatative cardiomyopathy in the sole patient with overt heart disease. There seems to be no relation between involvement of skeletal and cardiac muscle. It is likely, although not proved, that myocardial involvement in myotonic dystrophy occur initially as "myotonia", followed by a "dystrophic" phase with severe dilatative cardiomyopathy, not unlike the skeletal muscle.

Adolescent↗

[Thyroid tumors in the mediastinum].

The Authors studied 46 cases of thyroid neoplasm, characterized by a mediastinal involvement of different degrees, and analysed the epidemiologic, anatomo-pathological and clinical aspects thereof. Then, they, on the basis of their experience, outlined the formulation of the diagnostic ascertainments and surgical treatment.

Adult↗

A fixed combination of metoprolol slow-release and chlorthalidone, given once daily, in the long-term treatment of arterial hypertension.

A fixed combination of metoprolol slow-release 200 mg and chlorthalidone 25 mg was given once daily over a 3 months period in forty out-patients with mild-to-moderate arterial hypertension stage I or II WHO. The combination elicited a clear-cut antihypertensive effect lasting at least 24 hours after drug. As compared with pre-treatment values, systolic and diastolic blood pressures were gradually reduced within the first month of treatment, remaining nearly constant in the following 2 months. Treatment was well tolerated by all patients. Neither serum potassium nor any other laboratory test (creative, glucose, uric acid, etc) showed significant changes. In conclusion, slow-release metoprolol fixed association with chlorthalidone provides a safe and effective treatment of arterial hypertension even on a long-term basis. The once daily dosing schedule may considerably improve patient's compliance.

Adult↗