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Biomedical subjects

N Palestini

Publications and source records attributed to N Palestini.

50 records · Page 3Linked to original sources
PubMed1981

[Traumatic mitral insufficiency secondary to ruptured chordae tendineae. Discussion of one case (author's transl)].

One case of mitral insufficiency due to traumatic rupture of the posterior chordae is described. The most consistent clinical and non-invasive cardiovascular findings were: previous non-penetrating thorax trauma; rapidly progressing congestive heart failure; loud apical systolic murmur; sinus rhythm; normal radiological evidence of the left atrium; echocardiographic disorderly movement and coarse fluttering of posterior leaflet, systolic fluttering of mitral valve, diastolic additional echoes between mitral leaflets and systolic ones into the left atrium (due to ruptured chordae?). This patient underwent a valvular replacement surgery. When attempting a diagnosis of this accident, while haemodynamic and angiographic data are helpful mainly in the definition of retrograde mitral flow severity, the echocardiographic findings appears to be more important to state precisely the site and the kind of the lesion.

Chordae Tendineae↗
PubMed1979

[Calcified pseudocyst of the spleen. Report of a case].

The description of a case of calcific pseudocyst of the spleen has provided the opportunity for a review of the literature on the subject and for further study, on the basis of clinical and anatomo-pathological data, of the problem of the aetiopathogenesis of non-parasite splenic cysts.

Calcinosis↗
PubMed1979

[Clinical and hormonal evaluation of recurrence of goiter after thyroidectomy].

The incidence and features of goitre recurrences were investigated in a sample population of patients operated at the University of Turin Endocrine Surgery Centre. The following parameters were examined: sex, age, familial history of goitre, number of pregnancies, T3 and T4 levels, and TSH levels. Attention is drawn to the finding of significantly higher TSH values in the patients operated for recurrent goitre than in a series of persons free of recurrences after they had been operated on for goitre. Other workers have made the same observation, which is therefore regarded as a pointer to the correct interpretation of the recurrence of goitre.

Adolescent↗
PubMedDate not supplied

[Surgical treatment of Graves' disease: results in 108 patients].

AIM OF THE STUDY: To evaluate morbidity and functional results of surgical treatment in patients with Graves' disease. METHODS: A retrospective study was performed in 108 patients operated on during 1993-2003. Main indications for surgery were failure of treatment with antithyroid drugs (80.6%), large goiter (46.3%) and/or severe ophthalmopathy (23.1%). Surgical procedures were extensive subtotal thyroidectomy (EST; n = 33; uni- or bilateral remnant of <2 g) or total thyroidectomy (TT; n=75). Functional results were established in 89 patients (27 EST patients and 62 TT patients) after a mean follow-up of 5.9 years. RESULTS: Operative mortality was zero. There were 4 (3.7%) transient unilateral recurrent laryngeal nerve (RLN) palsies and no cases of permanent RLN palsy. Temporary hypocalcemia occurred in 15 patients (13.9%) and permanent hypoparathyroidism resulted in two (1.9%). Four patients (3.7%) developed a postoperative hematoma that required reoperation. There was no significant difference in the rate of complications between EST and TT, although temporary hypocalcemia was more common following TT than EST (17.3% vs. 6.1%) and permanent hypoparathyroidism affected only TT patients. None of the patients developed recurrent hyperthyroidism; all patients are maintained on levothyroxine. CONCLUSIONS: Surgery is an effective therapy for selected cases of Graves' disease. When performed by experienced surgeons, it can be carried out with no mortality and minimal morbidity. EST (with uni- or bilateral remnant of <2 g) and TT are both effective in order to achieve a definitive cure of hyperthyroidism.

Follow-Up Studies↗
PubMedDate not supplied

[Solitary ulcer of the rectum. Description of a case].

A case of solitary rectal ulcer is presented. Different views on the pathogenesis are discussed. Symptoms were nonspecific: anal pain, rectal tenesmus and bleeding. On sigmoidoscopy, the lesion has a characteristic appearance, but the definitive diagnosis of benignity must depend upon the recognition of specific histopathologic features in rectal biopsy specimens from ulcer margins. In this case, the surgical treatment was satisfactory, but frequently neither medical nor surgical treatment achieve relief of symptoms or healing of the lesion.

Adult↗
PubMedDate not supplied

[Evaluation of survival in a sample of patients treated with radical mastectomy for mammary carcinoma].

Survival and its modalities were studied in 40 patients subjected to Halsted's operation for breast cancer between 1960 and 1972. The following parameters were considered: age at time of surgery, onset of tumour before or after menopause, age of commencement of menopause, married or single, number of pregnancies, breast feeding, regularity of menstrual cycle, prior breast disease, time elapsed between first symptoms and mastectomy, side affected, quadrant affected, involvement of ipsilateral lymph nodes, histological type, complementary X-ray treatment, ovariectomy, and medical hormone therapy.

Adult↗
PubMedDate not supplied

[Relations between hypercalcemia and peptic ulcer].

Calcaemia and phosphoraemia have been evaluated in a group of patients suffering from gastroduodenal ulcer and in a control group suffering from various pathologies of surgical interest. A significant correlation was found to exist between these values and the presence of gastroduodenal ulcer and this is considered worthy of further clinical and experimental study.

Calcium↗
PubMedDate not supplied

[Prognostic value of nuclear morphology in colorectal neoplasms].

Cytomorphometry measures the main geometric parameters of the cell nucleus (area, min. and max. diameter, circunference) on ordinary histological preparations. It has been employed to asses the prognosis of breast and ovary tumours. The possibility that cytomorphometry, when allied with other parameters, such as age, sex, Duke's stage, bleeding etc., can be used in the prognosis of tumours of the large intestine is examined through a study of intraoperative biopsies from 44 patients followed after surgery. Univariate analysis showed that the Duke's stage and tumour site were significantly related to prognosis. The standard deviation of the maximum diameter and circunference were also related to survival with a negative correlation. Multivariate analysis confirmed the significance of the maximum diameter and the Duke's stage. These parameters were then used to calculate the relative risk. If due account is taken of the reservation expressed in the literature concerning the reproducibility of the data offered by cytomorphometry and its heavy dependence on the skill of the operator, it can be used to advantage in the prognosis of the colorectal tumours.

Adult↗
PubMedDate not supplied

[Prognostic value of nuclear morphometry in follicular carcinoma of the thyroid gland].

Histological material from 60 cases of follicular carcinoma of the thyroid operated between 1962 and 1987 was examined morphometrically to see whether this would produce data that could be correlated with survival. Nuclear parameters (area, perimeter, minimum and maximum diameter and their ratio, form factor) and the mitotic index were investigated. At the same time, account was taken of certain clinical parameters (sex, age, degree of differentiation, size of the primary lesion, extension of the tumour) potentially correlated with prognosis. Survival in relation to all these variables was examined by means of an actuarial method and subjected to both uni- and multivariate analysis. The results, although suggesting the existence of a relationship between nuclear size and the aggressiveness of this type of tumour, failed to demonstrate a significant correlation between these morphometric parameters and survival after treatment. By contrast, survival was significantly influenced by some of the clinical variables, particularly loco-regional extension of the disease and the patient's age. The prognostic significance of nuclear size was recently demonstrated in breast cancer and in a series of thyroid carcinomas including tumours with different morphologies and progression patterns. In follicular thyroid carcinoma the degree of cellular pleomorphism is usually low. So, morphometry does not seem able to provide information regarding prognosis more valuable than those obtained by the clinical data.

Adenocarcinoma, Follicular↗
PubMedDate not supplied

Primary hyperparathyroidism sustained by a giant adenoma of the parathyroid gland.

A case of primary hyperparathyroidism sustained by an unusually large parathyroid adenoma is presented. The tumor affected a 45-year-old woman with a 15-year history of nephrolithiasis and presented as a palpable neck mass. On the basis of clinical findings and ultrasound examination, it was initially misdiagnosed as a thyroid nodule. CT scan and transesophageal endosonography gave a correct definition of the tumor, which was located behind the left thyroid lobe and expanded posterior to the pharynx and the esophagus in the prevertebral space. At surgery a parathyroid tumor measuring 8 x 7 x 3 cm and weighing 90 g was successfully removed. No signs of malignancy were observed by both morphological and cell kinetic analyses.

Adenoma↗