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Biomedical subjects

N Penkov

Publications and source records attributed to N Penkov.

At least 37 records · Page 2Linked to original sources
PubMed1990

[The early bicycle ergometry test in drug-stabilized patients with unstable angina pectoris; its risk and benefit].

The risk of an early submaximum symptom-limited bicycle ergometry [correction of veloergometric] test and its prognostic value up to the end of the first year since the onset of unstable angina pectoris were studied in 258 patients with unstable angina pectoris who had been stabilized by medicamentous treatment. During the bicycle ergometry [correction of veloergometric] test no serious complications were observed. In 22 patients (35.7%) the test was negative and in 166 patients (64.3%) it was positive (angina pectoris and/or horizontal ST depression greater than or equal to 0.1 mV at 80 ms from the point J). In the patients with a positive test the prognosis is statistically worse (death, acute myocardial infarction, aortocoronary bypass, relapse of the unstable angina pectoris and angina pectoris of III and IV functional class according to NYNA/than in the patients with a negative bicycle ergometry [correction of veloergometric] test. The early bicycle ergometry [correction of veloergometric] test is with a high sensitivity (92.6%) and a lower specificity (66.7%) in recognizing the patients with a poor prognosis. The total prognostic accuracy of the test is 80.2%. It classifies the patients with unstable angina pectoris into two groups: with favourable and poor prognosis and helps in the selection of patients for surgical treatment.

Adult↗
PubMed1990

[The effect of an aortocoronary bypass on the physical capacity of drug-stabilized patients with unstable angina pectoris].

To 51 patients with unstable angina pectoris a submaximum symptom-limited bicycle ergometry [correction of veloergometric] test was performed 3 to 6 days after stabilization by medicamentous treatment was achieved and 2 to 6 months after an aortocoronary bypass had been accomplished. During the first veloergometric test myocardial ischemia was induced in all patients--9 patients were in the IV, 18--in the III and 24--in the II functional class according to NYHA. During the second veloergometric test myocardial ischemia was induced only in 5 patients. At the end of the first year after the aortocoronary bypass had been performed 45 (88.2%) of the patients were without complaints. The predictive value of the positive veloergometric test after an aortocoronary bypass for a poor prognosis is 80% and that of the veloergometric test without induced myocardial ischemia for a favorable prognosis is 95.6%. Aortocoronary bypass in combination with medicamentous treatment improves the symptomatic state, physical capacity and the prognosis of patients with unstable angina pectoris up to the end of the first year to a considerably greater degree than the medicamentous treatment alone.

Angina, Unstable↗
PubMed1990

[The long-term (10- to 13-year) prognosis of patients with unstable angina pectoris].

The prognosis after mean 11.4 (10-13) years of 249 patients with unstable angina pectoris, are 55.9 years, treated with contemporary drugs (in an intensive care coronary unit until the life-threatening symptoms were overcome, in a general cardiac unit until full clinical recovery and then in outpatient clinic) was studied. Till the end of the observation period 98 patients (39.4%) had a new myocardial infarction and a total of 110 patients (44.2%) died of ischemic heart disease (suddenly or after a myocardial infarction). The increased risk of acute myocardial infarction and lethal outcome in patients with unstable angina pectoris is determined by the persistence of the angina pectoris, after the hospitalization and in spite of the treatment, fluctuating ST-T changes in the ECG, inefficient left ventricular function, previous stable angina pectoris and a past myocardial infarction. These patients are indicated for a direct examination for assessment of the need of surgical treatment.

Adult↗
PubMed1989

[Long-term treatment of hypertension with a selective beta-1-blockader without sympathomimetic activity. II. Changes in the structure and function of the left ventricle].

The effect of the 6 months long treatment with the Hungarian selective beta-1-blocker Betaloc (Metoprolol) on the structure and function of the left ventricle was studied in 30 hypertensive patients--II stage (with echocardiographically proved left ventricular hypertrophy) by means of simultaneous recording of M-type echocardiogram, ACG, PCG and ECG. The telediastolic thickness of the septum and the posterior wall and the left ventricular muscular mass decrease at the end of the 6-th month (p less than 0.0001). The telesystolic dimension and volume decrease (p less than 0.0001) in the 6-th month without changes in the telediastolic dimension and volume (p greater than 0.32). The shortening fraction and the ejection fraction increase (p less than 0.0001), Vcf increases insignificantly (p greater than 0.05). The isovolumetric relaxation shortens (p less than 0.0001), the active suction period lengthens (p less than 0.0001) as well as the fast filling period (p less than 0.0027). By controlling the arterial pressure and suppressing the sympathetic stimulation of the heart the prolonged Betaloc treatment leads to reversion of the hypertrophy and improves the left ventricular function.

Cardiomegaly↗
PubMed1989

[The prognostic value of an early bicycle ergometry test and the management of patients with uncomplicated acute myocardial infarct].

In 75 men with uncomplicated acute myocardial infarction early symptom-limited submaximum bicycle ergometric test was performed 24-48 hours before discharge from hospital. 32 patients (42.7%) showed a positive test (ST-depression greater than 0.1 mV with duration of greater than or equal to 0.08 s and/or angina pectoris). The prognosis assessed by the number of cases with unstable angina pectoris, recurrent myocardial infarction or sudden death in the patients with positive test is significantly worse (p less than 0.0001). The patients with positive early bicycle ergometric test are indicated for direct examination and are potential candidates for aortocoronary bypass or percutaneous transluminal coronary angioplasty. An algorithm for attitude toward patients with uncomplicated acute myocardial infarction is presented.

Adult↗