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Biomedical subjects

N Penkov

Publications and source records attributed to N Penkov.

53 records · Page 3Linked to original sources
PubMed1989

[Long-term (beyond 5 years) prognosis of successfully resuscitated patients with ventricular fibrillation].

An investigation was carried out of 58 patients who had survived ventricular fibrillation during the period 1975-1982 and had been successfully resuscitated in the Cardiologic Clinic of the High Medical Institute in Varna. 12 of the patients were women and 46 were men, mean age 60.8 years (from 43 up to 85 years). 3 of the patients were dropped out of the investigation because of lack of information. 35 patients (63.6%) had died and 20 patients (36.4%) were alive. 4 of the alive patients (20%) had resumed their previous occupation. 3 of the patients (15%) were on old age pension but were engaged in some kind of work. 12 patients (60%) were old age pensioners or on a disablement pension but in good functional class. Only one patient (5%) was in a bad physical condition confined to bed. Ventricular fibrillation has a poor prognosis but if timely and properly treated it could be overcome and the life of the patients could be prolonged. Some of the patients could live a wholesome life for a long period of time (more than 5 years).

Adult↗
PubMed1988

[Hemodynamic changes and left ventricular function in patients with hypertension during an acute trial of urapidil].

The left ventricular hemodynamic changes were studied in 9 hypertensive patients (6 patients with hypertensive attack and 3 patients with a severe form of the disease) by simultaneous recordings of the M-type echocardiogram, apexcardiogram and phonocardiogram in an acute trial with Urapidil administered intravenously in a dose of 0,7 mg/kg body mass. The arterial pressure and the peripheral vascular resistance decrease. The stroke and the minute volume do not change. The heart rate increases. The telediastolic and telesystolic dimensions of the left ventricle decrease. The percentage amplitude of the aI-wave of the apexcardiogram also decreases. The fraction of the shortening of the left ventricular dimension increases with 23,0%, the ejection fraction increases with 13,5% and the average speed of the circumferential fibres shortening increases with 21,4%. Urapidil applied i.v. exerts a rapid hypotensive action and improves the left ventricular function.

Adult↗
PubMed1988

[Long-term treatment of hypertension with a selective beta l-blocker without sympathomimetic activity. I. Antihypertensive and hemodynamic effects].

The antihypertensive and hemodynamic efficacy of Betaloc (Egys-Hungary) was studied in 30 hypertensive patients in the II stage of the disease. The drug was applied in a single daily dose of 100 mg in the course of 6 months. The systolic and diastolic pressure and the heart rate decreased reliably (p less than 0.0001) at the end of the first month. The stroke volume increased (p less than 0.045) at the end of the sixth month but the minute volume and the cardiac index did not change (p greater than 0.32). The peripheral vascular resistance dicreased reliably (p less than 0.02) at the end of the sixth month--the degree depending on the initial type of circulation--and it determined the longstanding antihypertensive efficacy of Betaloc. No untoward reactions were registered.

Adult↗
PubMed1988

[An apex cardiographic method of determining the moment of mitral valve opening and duration of its isovolumetric relaxation].

By analyzing the simultaneous recordings of M-type echocardiogram of the mitral valve, apexcardiogram (ACG) phonocardiogram (PCG) in 49 healthy persons, 30 patients with II stage hypertension and 39 patients with unstable angina pectoris was established that the opening of the mitral valve coincides with the moment in which the discending arm of the ACG deviates from its tangent (determined by two points--the first is the point of intersection of the ACG with the perpendicular raised from the initial highfrequency vibrations of the aortic component of the II tone: the second is 20 ms from the first on the discending arm of the ACG). The method allows the determination of the exact moment of the opening of the mitral valve and the duration of the isovolumetric relaxation and of the period of the active suction by the ACG and the PCG only. This increases the apexcardiographic potentialities in the functional diagnosis of the left ventricle.

Adult↗
PubMed1987

[Treatment of ectopic ventricular activity with palpitin (disopyramide)].

The therapeutic effect of palpitin (Gedeon Richter) was examined in an open clinical experiment with 30 patients with ectopic ventricular activity. The mean number of ventricular extra-systoles, established for one hour, was reduced from 573.7 to 149.7(p less than 0.001)--in 30.0% of the treated it completely disappeared, in 56.7% it was reduced with more than 50% and in 13.3%--there was no effect. The adverse effects are often (33.3%) but light, rarely necessitating the discontinuation of the treatment.

Adult↗
PubMed1987

[Relaxation and rapid filling of the left ventricle in essential hypertension during treatment with a non-selective beta blocker].

Some indices of relaxation and rapid filling were evaluated in the course of a six-month treatment with non-selective beta-blocker in 30 patients with hypertonic disease, (HD), degree II, with echocardiographically confirmed left-ventricular hypertrophy and normal systolic function. The phase analysis of the early diastole, performed according to Alvarez and Goodwin, reveals a progressive shortening of the period of isovolumetric relaxation and lengthening of the period of active suction with no change in the summed up period of rapid relaxation; the period of rapid filing is lengthened on account of the active suction. The evaluated via computer analysis (echo-computer--NIEMT-MA, Sofia) parameters of rapid filling of M-type echogram of left ventricle (maximum velocity of increase of left-ventricular dimension, mean velocity of fraction of rapid filling) increase progressively. The dynamics of the indices of diastolic function described, reflect the diminution of the restriction of ventricular filling and its shifting to the early diastole.

Adrenergic beta-Antagonists↗
PubMed1987

[Early diastolic changes in patients with unstable angina pectoris].

The length of the time intervals of the early diastole was studied by the method of Alvares and Goodwin in 30 patients with unstable angina pectoris by means of simultaneous recordings of M-type echocardiogram, ACG,PCG and ECG before and after medicamentous treatment (beta blockers, nitrites with prolonged action, calcium antagonists). The control group was of 33 healthy men. The isovolumetric relaxation period was greatly prolonged in the patients and the active aspiration period was shortened (p less than 0.001). At the end of hospital treatment the interrelations between these two periods changed--the isovolumetric relaxation period shortened (p less than 0.001) and the active aspiration period lengthened (p less than 0.01) without change of the total period of fast relaxation. The slow relaxation period during the time of fast filling and the total fast filling period before and after treatment did not differ from those of the control group. The changes of the time intervals are probably related to the diminished compliance due to myocardial ischemia. The dynamic changes in the course of medicamentous treatment of unstable angina pectoris reflect the lowered restriction of left ventricular filling.

Adult↗
PubMed1986

[Clinical study of the beta-blocker chlorpropanol (tobanum) in hypertension patients].

The antihypertensive effect and tolerance of chlorpropanol was determined in 30 patients with hypertonic disease. The treatment was carried out only with tobanum as an open experiment with a dose from 10 to 30 mg. Before and towards the end of the treatment, the following indices were calculated from the simultaneous record of M-echocardiogram of left ventricle, ACG, PhCG and ECG: stroke volume (SV), minute volume (MV) cardiac index (CI), ejection fraction (EF), mean velocity of circumferential fibres shortening (Vcf), and peripheral vascular resistance (PVR). Chlorpropanol normalized the pressure in 83.3% of the treated, reducing the systolic pressure with 14.9%, and the diastolic--with 15.1%. The reduction of the pressure in hyperkinetic type of circulation is associated with the reduction of CI (p less than 0.05) as result from the slowed down cardiac rate (p less than 0.001), in hypokinetic type--with the reduction of PVR (p less than 0.05), and in eukinetic--with the normalization of the ratio between those two parameters. EF was not changed during the treatment, Vcf was reduced (p less than 0.045), but remained within the physiological limits. Chlorpropanol is with pronounced negative chronotropic effect. It has a good tolerance.

Adrenergic beta-Antagonists↗
PubMed1986

[Treatment of hypertension with urapidil (Ebrantil)].

Ebrantil has been added to the beta-blockers and/or diuretics in the treatment of 32 patients with moderate and severe hypertension under the conditions of 3-month open clinical experiment. A very good antihypertensive effect was obtained in 31.3% of the treated, moderate--in 65.6% and unsatisfactory--in 3.1%. Ebrantil does not change the heart rate and is, in fact, without any adverse effects.

Adrenergic beta-Antagonists↗
PubMed1986

[Treatment of hypertension with obsilazin].

Obsilazin was established to have a good to moderate hypotensive effect in 75% of the treated 36 patients with moderate and severe hypertension under the condition of a 6-month open clinical experiment, not changing the heart rate. The adverse effects are often 69.4%), usually transitory but in 11.1% they proved to be the cause for discontinuation of the treatment.

Adrenergic beta-Antagonists↗
PubMed1985

[Treatment and prevention of paroxysmal atrial fibrillation and flutter with quinidine retard].

The ability of quinidine retard of restoring sinus rhythm and further maintenance after successful regulation were checked in 42 patients with flutter and fibrillation in an open clinical trial. Quinidine retard restores the sinus rhythm in less patients (60.0%) than quinidine sulphate (81,8%). At the same time, it maintains sinus rhythm in 91,4 per cent of the cases in anti-recurrence treatment. That makes quinidine retard adequate for long-term administration.

Adult↗
PubMed1984

[Treatment of paroxysmal supraventricular tachycardia and tachyarrhythmia with verapamil].

The antiarrhythmic effect of isoptin was verified in 47 patients--30 with paroxysmal supraventricular tachycardia and 17--with paroxysmal ventricular fibrillation: in case of paroxysmal supraventricular tachycardia with 5--10 mg isoptin i.v. for the restoration of sinus rhythm and with 240--320 mg orally for maintaining the effect and in case of ventricular fibrillation--i. v. for the slowing down the heart rate. Isoptin, i. v. applied, restores the sinus rhythm in 93,3 per cent of the patients with paroxysmal supraventricular tachycardia and in 17,6 per cent--with ventricular fibrillation and slowsdown the heart rate in 94,6 per cent among those with ventricular fibrillation. The oral isoptin reduces the paroxysms of the supraventricular tachycardia in 86 per cent and slowsdown the sinus rate and lengthens PQ.

Adult↗
PubMed1975

[Quantitative prognosis in acute myocardial infarct; the efficiency of the Peel index and its modificantion with 398 patients].

Making use of "coronary prognostic index" of Peel and its modifications, a retrospective assessment is performed on the state of 398 patients with acute myocardial infarction with a mark, equal to the sum of marks of the signs of the initial myocardial period, allowing the prediction of the lethal end in the first 28 days of the onset of the disease. The predicted lethality for the corresponding mark intervals was established to be close to the real and that both systems show similar real lethality for the separate mark intervals. Modified Peel system proved more effective: it provides an average of 0,015 bits more information for the disease outcome than the analogic system of Peel. Peel index and its modification are insufficiently complex but easily accessible and sufficiently provable as to be used in every day practice in order to differentiate the patients with poor prognosis and take better care of.

Acute Disease↗