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Biomedical subjects

N R Farnsworth

Publications and source records attributed to N R Farnsworth.

At least 127 records · Page 7Linked to original sources
PubMed1976

Sinoacutine from Glaucium contortuplicatum Boiss.

A phytochemical investigation of Glaucium contortuplicatum Boiss. (Papaveraceae) resulted in the isolation of sinoacutine from this plant for the first time. Spectral evidence for the identity of the isolated compound as sinoacutine is presented.

Morphinans↗
PubMed1976

Oncogenic and tumor-promoting Spermatophytes and Pteridophytes and their active principles.

A survey and discussion are presented of plants classified as Spermatophyta and Pteridophyta, extracts of which have been shown to be oncogenic or tumor-promoting in animals. The active oncogenic and tumor-promoting principles, where known, have been identified. They represent tannins; pyrrolizidine, indole, tropolone, quinoline, purine, and benzophenanthridine alkaloids; nitroso compounds; triterpene glycosides; lignans; isoflavans; allyl benzenoids; simple (nu-pyrenes; and carbocyclic hydroxy acids. A total of 28 compounds of known structure have been identified as oncogens and several phorbol esters as tumor-promoters. Plants known to contain any of the 28 oncogens (excluding shikimic acid and caffeine) have been tabulated; they represent at least 454 species, 110 genera, and 34 families of Spermatophyta and Pteridophyta.

Animal Feed↗
PubMed1975

Alkaloids of Vinca species V: structure elucidation of herbadine, an alkaloid isolated from Vinca libanotica.

Herbadine, a novel dihydroindole alkaloid, was isolated from the arterial parts of Vinca libanotica Zucc. (Apocynaceae). The physical and spectral data (UV, IR, NMR, and mass spectroscopy) indicated the alkaloid to be a derivative of aimaline. Comparative high-resolution NMR studies with quebrachidine and high-resolution mass spectral studies established the structure of the alkaloid to be 2-epi-3-hydroxyquebrachidine. Herbadine was previously isolated from another species by Russian workers and a structure was postulated. The current paper gives evidence for a corrected structure of herbadine.

Ajmaline↗
PubMed1975

Cytotoxic principles of Parquetina nigrescens (Afzel.) Bullock (Asclepiadaceae).

Systematic fractionation of the cytotoxic extracts of the roots of Parquetina nigrescens (Afzel.) Bullock (Asclepiadaceae) on silica gel column chromatography led to the isolation of three cardenolides: cymarin, strophanthidin, and a strophanthidin glycoside (XS-89). Also isolated during the investigation were beta-sitosterol-beta-D-glucoside, a mixture of alpha- and beta-amyrins, a mixture of alkanols, and a mixture of plant sterols.

Animals↗