Biomedical subjects

N Reinsmoen

Publications and source records attributed to N Reinsmoen.

9 recordsLinked to original sources

PubMed1990

The molecular basis of alloreactivity.

The strength of the immune response to foreign histocompatibility molecules has long puzzled immunologists. In this article Robert Lechler and colleagues propose that (1) allorecognition is structurally heterogeneous and varies according to the responder and stimulator MHC types, (2) in closely related combinations the focus of the alloreactive T cell may be on epitopes of endogenous peptides that are displayed by stimulator but not by responder MHC molecules, seen in a 'self-restricted' manner, and (3) in more disparate combinations the alloresponse may be directed primarily against residues on the allogeneic MHC molecule itself.

Amino Acid Sequence↗

PubMed1979

B lymphocyte determinants in immunoglobulin A nephropathy.

Because of our prior demonstration of a strong association betwen a specific B lymphocyte determinant and the occurrence of chronic membranoproliferative glomerulonephritis and the demonstration by others of the frequent concurrence of an IgA deposit disease, anaphylactoid purpura nephritis,with HLA-BW35, we conducted an investigation of the association among Minnesota Caucasians of the HLA markers BW35, DW1 and B lymphocyte determinants identified by three alloantisera with IgA nephropathy and the syndrome of recurrent macroscopic hematuria. The highly significant association between HLA-BW35, DW1, and B cell antigens identified by alloantisera L, B, and F, present in 50 normal Minnesota Caucasians, was not observed in 18 Minnesota patients with IgA nephropathy. The frequency of HLA-DW1 was the same among controls and patients, whereas the relative risk of developing IgA nephropathy was demonstrated to be increased 4- to 5-fold in the presence of the B cell antigens identified by alloantisera L and B. These sera appear to identify determinants on B lymphocytes associated with the disease state and possibly not intimately related to the HLA-D region. These findings emphasize the possible informativeness of defining B cell alloantisera on disease panels.

Antilymphocyte Serum↗

PubMed1977

Lymphoblastoid cell lines of homozygous typing cells used for sensitization in PLT.

Lymphoblastoid cell lines of homozygous typing cells were used as the sensitizing cells in MLC to prepare PLT cells. Results obtained using such cells against a panel of restimulating cells were compared to those obtained using regular PLT cells in which priming had been accomplished with normal peripheral blood lymphocytes. It appears that lymphoblastoid cell lines can be used for this purpose; the advantages of such an approach are given.

Cell Line↗

PubMed1977