[Observation of chondromatous hamartoma with the signs of malignancy].
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Biomedical subjects
Publications and source records attributed to N S Opanasenko.
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For the 15-year period of time 2 patients with myelogenetic disease (MD) and concomitant exudative pleuritis were observed in the clinic. In one of them with MD diagnosed 3 years before there was nonspecific (occurred after the pleuropneumonia) pleuritis. In the other patient the MD was diagnosed after revealing of characteristic cells in pleural exudate.
Pseudochylothorax--a rare disease, occurring in prolonged persistence of exudate in the cavity of fibrotically changed pleura. Three observations of pseudochylothorax, including as the complication of viral hepatitis A, are adduced. Diagnosis was established after biochemical analysis of exudate, obtained during pleural puncture.
Three patients were operated on for the tracheal bronchus (TB) in the clinic. All the patients had right-sided TB localization and other inborn concomitant pathology of bronchopulmonary and cardiovascular systems. One patient, who had concomitant pathology of cardiovascular system with TB, died due to continuing pulmonary hemorrhage.
For the period of 21 years the intralobar pulmonary sequestration was revealed in 6 patients aging from 11 to 47 years old. In all the observations of the intralobar sequestration the only affection of lower pulmonary lobes was noted. In 4 patients the symptomless course of the disease was present, while in 2 it was manifested by the recurrent pneumonia. The correct diagnosis before the operation was established in one patient only. All the patients were operated on, in 2 two aberrant vessels to the sequestrated pulmonary region were revealed and in all the patients--bronchogenic cyst in the affected region.
Six patients with carcinosarcoma were observed in the clinic. In 4 patients with roentgenological signs of tumor were determined and in 2--the signs of pleuritis. The diagnosis was established after pulmonary resection performance or after thoracoscopy with pleural biopsy conduction.
Retrospective analysis of 58 patients history cases, in whom pleural mesothelioma was diagnosed, was conducted. Clinical signs of the disease were: progressive pain in the chest on the affection side, permanent fever, dyspnoea, weakness, rapid accumulation of pleural liquor. The combined application of clinico-roentgenological, laboratory and instrumental methods of examination has great significance in diagnosis. The informativity of transthoracic puncture with pleural biopsy is 36.2%, and of thoracoscopy-84.3%. Diagnostical thoracotomy was performed when indications were present.
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Klaforan pharmacodynamics was studied up in pleural exudate and blood serum of the patients with purulent-destructive pulmonary diseases after its single endolymphatic and intravenous introduction in the dose 60 mg/kg of the body mass. Convalescence frequency in control group was 61.6%, in principal-82.9%, lethality-18.6 and 9.3% accordingly.
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The indices of acid-base and pepsino-acid coefficients (ABC and PAC) in 99 patients with a duodenal ulcer, who previously underwent closure of its perforation and in 22 patients with uncomplicated course of the disease were studied. The control group included 22 healthy subjects. In patients after closure of a perforative duodenal ulcer, the low ABC and PAC indices may be indicative of the absence of stable disease remission and possibility of the development of a repeated complication.
The immunity status was studied in patients with acute pyo-destructive lung diseases complicated by purulent pleurisy (relative counts of T- and B-lymphocytes, subpopulation composition of T-cells, numbers of lymphocytes-killers, and functional state of neutrophils of the peripheral blood). These patients revealed significant cellular immunodeficiency, rise in B-lymphocytes, and apparent changes in the activity of the peripheral blood phagocytes. The endolymphatic drug route was found out to be superior to conventional ones in that it had more expressed normalizing action on the quantitative and functional state of T-lymphocytes, their subpopulation composition (manifested by augmentation of T-cells-helpers), as well as on the level of B-lymphocytes, lymphocytes-killers, and metabolic activity of neutrophils of the peripheral blood.