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Biomedical subjects

N S Penneys

Publications and source records attributed to N S Penneys.

At least 109 records · Page 6Linked to original sources
PubMed1988

Alveolar rhabdomyosarcoma arising in the nasal cavity of a 3-year-old child.

A 3-year-old girl had a large exophytic mass protruding from the nares, of seven months' duration. Routine microscopic studies demonstrated a tumor composed of solid sheets of small cells, with scattered foci lining alveola-like spaces. Immunohistochemical studies demonstrated the presence of desmin and myoglobin, and the absence of prekeratin, neuron-specific enolase, and leukocyte common antigen. These observations are consistent with the diagnosis of alveolar rhabdomyosarcoma.

Child, Preschool↗
PubMed1988

Quantitation of S100 protein-positive cells in inflamed and non-inflamed keratoacanthoma and squamous cell carcinoma.

Langerhans cells (LC) were identified and quantitated in non-inflamed keratoacanthoma (KA), inflamed KA, non-inflamed squamous cell carcinoma (SCC), and inflamed SCC, by their content of S100 protein. The number of LCs per high-power field was markedly increased in inflamed KA when compared to the other groups. Using similar methods on frozen sections, the expression of HLA-DR was identified on keratinocytes in KA in areas of inflammation but not in other lesions under study. We hypothesize that increased numbers of LCs in inflamed KA are part of the process which results in tumor regression.

Carcinoma, Squamous Cell↗
PubMed1988

Analysis of morpheaform basal cell carcinoma.

Biopsies of morpheaform basal cell carcinomas (MBCCs) were separated into 2 groups based on histological features: 1) a pure morpheaform group with narrow elongated strands of basaloid cells in a dense fibrous stroma; and 2) a complex morpheaform group with pure morpheaform regions as well as regions with other histological patterns (nodular, etc.). Analysis by sex and body location revealed a female predominance in the pure morpheaform group. Lesions were found primarily on the mid-face in women with pure MBCCs. Using a monoclonal antibody which identifies eccrine duct in routinely fixed tissues, we could not identify eccrine ductal differentiation in MBCCs.

Basal Cell Carcinoma↗
PubMed1988

Monoclonal antibody ERY-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas.

We have identified a monoclonal antibody (ERY-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. The antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. No reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. It is possible that ERY-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involved in erythropoiesis in various stages of human development. Furthermore, ERY-1 has proved to be extremely useful in the histopathologic diagnosis of hepatocellular and renal cell carcinomas.

Antibodies, Monoclonal↗
PubMed1988

Generation of multiple monoclonal antibodies for diagnostic use from a single hybridoma fusion.

BALB/c mice were exposed simultaneously to three nonrelated immunogens, myelin basic protein, uridyl-galactosyl transferase, and tissue obtained from a formalin-fixed, paraffin-embedded block containing a pilomatrixoma. Standard hybridoma techniques were used and antibody generation assayed using an unlabelled antibody biotin-avidin method with sections of human cerebellum, liver, and pilomatrixoma as the substrates. Using the above assay, clones were selected that secreted antibodies with selective specificities for each of the immunogens. By ELISA assay, the monoclonal antibodies reacting with cerebellum also reacted to the myelin basic protein preparation used as immunogen and the monoclonal antibody reacting to hepatocytes bound to the preparation of uridyl-galactosyl transferase used as immunogen. Our data suggests that the generation of monoclonal antibodies with a variety of diagnostic applications can be obtained from a single fusion following immunization with multiple nonrelated antigens, requiring considerably less laboratory cost and effort than would be required to obtain similar monoclonal antibodies in separate fusions.

Animals↗
PubMed1988

AIDS in black patients.

Dermatologists function as consultants in the management of AIDS. They are consulted for care of cutaneous complications such as superficial infections (viral, dermatophyte, deep fungal, and bacterial). The management of these problems is similar to that in individuals with intact immune systems; however, these processes when associated with HIV infection may be more persistent and may recur.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Complex viral and fungal skin lesions of patients with acquired immunodeficiency syndrome.

Three patients with acquired immunodeficiency syndrome were noted to have skin lesions in which there were histologic changes supporting the presence of both fungal and viral pathogens. Skin lesions were found in the patellar region in two patients and in the groin in one patient. Skin biopsies revealed massive epidermal hyperplasia, cytopathic changes of herpesvirus infection in all three patients, papillomavirus in one patient, and septate hyphae in the stratum corneum in all patients. The coexistence of fungal and viral infection produces an epidermal response that in some features resembles that seen in keratoacanthoma.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Interface dermatitis in patients with the acquired immunodeficiency syndrome.

We report twenty-five patients with the acquired immunodeficiency syndrome (AIDS) and interface dermatitis. Patients with AIDS and interface dermatitis had numerous opportunistic and herpetic infections. Nearly all patients were receiving at least one medication prior to the development of their rash and many were clinically thought to have a drug eruption. When compared to skin biopsy specimens from non-AIDS patients with drug eruptions, specimens from patients with AIDS and interface dermatitis demonstrated a greater degree of vacuolar change, the frequent occurrence of necrotic keratinocytes, often in clumps, and the absence of eosinophils and polymorphonuclear leukocytes in the dermal infiltrates. Histologic and clinical features of our patients with AIDS and interface dermatitis are presented and contrasted with other interface dermatitides. Systemic and cutaneous immune abnormalities in patients with AIDS may be relevant to the pathogenesis of this interface process.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Microinvasive lentigo maligna melanoma.

Ninety-one skin biopsy specimens previously identified as lentigo maligna were examined for the presence of microinvasion, using the demonstration of S100 protein within atypical cells as the means for locating these superficial foci. In 14 cases, atypical melanocytes were identified, most often in the papillary dermis. The mean depth of invasion in this group was 0.23 mm with a range of 0.10 mm to 0.75 mm. In these cases, atypical cells were difficult if not impossible to identify in routinely processed sections, either because the invasive cell was a spindle cell variant and indistinguishable from a fibrohistiocytic cell, because the invasive cells were occasionally solitary or in small groups, or because there was an inflammatory infiltrate that obscured the tumor cells. Recent studies of lentigo maligna melanoma have revealed no better prognosis when compared to that of other forms of malignant melanoma after normalization for depth and body location. We therefore advocate close examination of lentigo maligna with the use of appropriate immunohistochemical techniques if there are areas of dermal fibrosis or inflammation that might obscure invasion.

Aged↗
PubMed1987

Coexistent pemphigus vulgaris and Paget's disease of the nipple. An immunohistochemical study.

We report the coexistence of pemphigus vulgaris and Paget's disease of the nipple in a patient with a documented history of pemphigus and a 2-year complaint of an eczematous breast lesion. A biopsy taken from the lesion showed the characteristic histologic features of both pemphigus and Paget's disease of the nipple. Immunohistochemical technics revealed intercellular IgG deposits characteristic of pemphigus and intracellular staining with antibody to epithelial membrane antigen in the cytoplasm of Paget's cells. This report is the first describing the coexistence of these two distinct disease entities in one tissue sample. This case underscores the necessity of early biopsy of recalcitrant nipple lesions even in the presence of another, well-documented skin disorder.

Biopsy↗
PubMed1987

Dermatopathologic findings in patients with acquired immunodeficiency syndrome.

We recently undertook a survey of all patients with acquired immunodeficiency syndrome (AIDS) seen at the University of Miami/Jackson Memorial Medical Center (UM/JMMC) and reviewed all skin biopsies received from these patients. Skin was the second most common organ biopsied; 36% of all patients (78/217) with AIDS had at least one skin biopsy. Kaposi's sarcoma (KS), the most frequent diagnosis, was seen in 47% of the biopsy specimens. Cutaneous infection, most commonly herpes simplex infection, was present in 19%. Atypical presentations of common dermatologic infections were also seen. Among the patients with neither KS nor infection, 16 had a vacuolar type of interface dermatitis.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Vasopressin-induced bullous disease and cutaneous necrosis.

Intravenous vasopressin is a commonly used modality for control of bleeding esophageal varices. The development of ischemic cutaneous complications is a recently described entity. In previous reports, cutaneous necrosis has occurred at sites of extravasation, at or proximal to intravenous catheter sites, or at isolated pressure points. We review the literature on vasopressin-induced cutaneous reactions and report a case of cutaneous necrosis and bulla formation in which multiple bullae formed during vasopressin therapy at sites distant from direct intravenous flow.

Aged↗
PubMed1986

von Willebrand factor antigen levels in Kaposi's sarcoma.

Consistent elevations of plasma von Willebrand factor antigen were observed in otherwise healthy elderly patients with Kaposi's sarcoma. The elevations were predominantly of the endothelial cell--derived antigen, as opposed to the factor VIII procoagulant, with resultant elevations in the antigen/procoagulant ratios. Lesser elevations were seen in a group of age-matched control subjects who did not have Kaposi's sarcoma or intercurrent illness. The greater elevations in plasma von Willebrand factor antigen therefore appear to be the direct consequence of the presence of Kaposi's sarcoma cells. Our findings also suggest that there is a direct relationship between tumor load and degree of von Willebrand factor antigen elevation.

Acquired Immunodeficiency Syndrome↗
PubMed1986

S100-protein-containing dendritic cells in fetal and newborn epidermis and thymus.

Skin and thymus were obtained from abortuses of varying ages and from neonatal autopsies to determine if S100-protein-containing dendritic cells were present. Using an unlabeled antibody peroxidase-antiperoxidase method, we could not detect these dendritic cells in epidermis prior to live birth, but did detect them at all fetal ages in thymus. Within 24 hours of live, full-term delivery, dendritic cells containing S100 protein were identified in epidermis.

Fetus↗
PubMed1986

The identification of molluscum infection by immunohistochemical means.

Tissue obtained from formalin-fixed, paraffin-embedded blocks containing molluscum contagiosum virus was used as a source of antigen to generate a polyclonal antibody against molluscum contagiosum virus. This antibody recognized an antigen in molluscum bodies which was preserved during routine fixation and embedding. The antibody can be used with standard immunohistochemical methods to identify molluscum contagiosuminfection in inflamed and distorted tissue specimens. Our data indicate that paraffin-embedded, formalin-fixed material can be used as an antigenic source to generate antibodies with diagnostic potential.

Antibodies↗
PubMed1986

Immunohistologic identification of fungi in systemic and cutaneous mycoses.

Using specific antibodies and the peroxidase-antiperoxidase technique, we were able to demonstrate a variety of fungal organisms in smears and sections of formaldehyde-fixed, paraffin-embedded tissue. The procedure is simple, fast, and accurate and may be used as an alternative to, or in conjunction with, cultural methods to identify fungi specifically.

Animals↗
PubMed1986

Multicenter study comparing 0.05% gel formulations of desoximetasone and fluocinonide in patients with scalp psoriasis.

A double-blind, multicenter study was conducted to evaluate and compare the safety and efficacy of desoximetasone gel 0.05% and fluocinonide gel 0.05% in patients with scalp psoriasis. One hundred twenty-five patients were enrolled in this randomized, parallel-group trial. Responses based on clinical assessment in 123 patients showed that the desoximetasone gel formulation is a safe and effective treatment for psoriasis of the scalp. Although efficacy appears equivalent to that of fluocinonide gel 0.05% in treating psoriasis of the scalp, desoximetasone appears to be slightly better tolerated and better accepted cosmetically.

Administration, Topical↗