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Biomedical subjects

N Sprem

Publications and source records attributed to N Sprem.

At least 37 records · Page 2Linked to original sources
PubMed1986

[The fascia and perichondrium in reconstructive surgery of the middle ear].

Analysis of 140 patients operated on for chronic otitis media showed that the perichondrium possesses biological qualities similar to those of the fascia, although it is used less often. When using the fascia, perforations occurred in 16% of the operated patients, whereas when using the perichondrium the incidence was 20%. Improved hearing when using the perichondrium was observed in 69%, and when using fascia in 42%. Functional results with the perichondrium were much better than with the fascia.

Audiometry, Pure-Tone↗
PubMed1986

[Functional results following stapedectomy. A 5-year study].

Results of partial stapedectomy with the formation of small fenestra and the use of teflon piston prostheses in the period of 1980-1984 are shown. Particular attention was paid to the group of patients under 18 years of age representing 3.3% of all operated cases, as well as to patients with combined hearing loss. In both groups, functional results of surgery were very good. Of the total of 284 operated ears, there were 20 reoperations.

Adolescent↗
PubMed1977

[Incus homografts (author's transl)].

The problem of reconstruction of the ossicular chain is still partly unsolved. A possible way of solving this problem is with a homograft in cases with total or partial ossicular chain defect. The method of preparing the homografts in our Clinic is described. The formation of an ossicular bank is quite easy, the procedure for preparing adequate implants simple and safe. This is a preliminary report concerning patients under review from 3--24 months, on whom the described method was used.

Ear Diseases↗
PubMed1976

[Incus homograft--histological study of implanted ossicles (author's transl)].

The methodes of obtaining, preparing and storing of ossicles for homoiotransplantation is described. Using this method, 21 patients have been operated. Four reoperations have been performed, and in two cases implants were found and subsequently subjected to histological analysis. The method of preparing the histological slides is described. The study of examined homografts revealed the normal bone structure and signs of revitalisation, which is clearly shown in the micrographs. On the basis of functional results and histological examination, the authors conclude that the use of devitalised homografts is recommanded in total and/or partial defects of ossicles.

Ear Ossicles↗
PubMed1976

[Malignant case of angiofibroma (author's transl)].

Various opinions about the etiopathogenesis of angiofibroma are mentioned. The authors, however, have not succeeded in confirming the frequently mentioned theory of hormonal formation of these tumours. It appears that surgical therapy is the only efficient way today of providing a clear view and a rapid radical removal of tumours, thus reducing the usually profuse haemorrhage during surgical treatment. Pre-operative ligation of the external carotid artery has no noticable effect on the reduction of haemorrhage during the operation. X-rays have no effect on the growth of the tumours. There is no great difference between the histological picture of a primary tumour and that of its recurrences. The malignant course of an angiofibroma in an adult is described which recurred several times and led to the involvement of the endocranium with a letal ending. The histological picture remained unchanged all the time. A spreading of the tumour was noticed in areas distant from the primary localisation of the tumour which we consider to be due to implantation and which indicates great potential growth of tumour cells of this angiofibroma.

Adult↗
PubMedDate not supplied

Arachidonic acid metabolites and sinonasal polyposis. I. Possible prognostic value.

PURPOSE: The etiology of sinonasal polyps is sometimes obscure. This study was undertaken to evaluate the potential role of arachidonic acid metabolites (AAm) on recurrent polyposis. MATERIALS AND METHODS: Tissue production of prostaglandin E2 (PGE2), 6-keto-prostaglandin F1-alpha (PGI2), thromboxane A2 (TxA2), and leukotriene C4 (LTC4) by nasal mucosa was determined by radioimmunoassay in 27 patients with sinonasal polyposis (SNp) and in 10 volunteers. RESULTS: The group of patients with SNp with the evidence of recurrences in postoperative period (Group 1) showed significantly lower PGE2 concentrations than group of patients with SNp recurrences (Group 2). The differences in concentrations of PGI2 in mentioned groups were insignificant. In comparison with other groups, a group of patients who underwent surgery several times for SNp (Group 4) had a higher mean TxA2 concentration. The LTC4 concentrations were the highest in groups of patients where SNp recurrences were observed. When the incidence of polyposis recurrences (within 18 months after surgery) was correlated with the level of LTC4 production at the time of surgery, the rate of recurrence was significantly higher in patients with increased LTC4 level than in those with normal LTC4 levels. CONCLUSIONS: LTC4 might have a prognostic value. The possible role of AAm in occurrence of SNp is apparent and suggests possible role for medical intervention.

6-Ketoprostaglandin F1 alpha↗
PubMedDate not supplied

[Granuloma of the oval window after stapedectomy].

A case report is presented of a female patient who underwent stapedotomy with bad functional results Reoperation revealed a dislocated prosthesis and there was no successful hearing. Besides conduction deafness perceptive deafness occurred as well. The second reoperation disclosed reparative granuloma around the prosthesis, while histological analysis showed foreign-body granuloma. Foreign-body granuloma by stapedectomy is extremely rare and it was the first case in our 810 surgically treated ears.

Adult↗