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Biomedical subjects

N Tabata

Publications and source records attributed to N Tabata.

117 records · Page 7Linked to original sources
PubMed1985

Studies on asphyxia: on the changes of the alveolar walls of rats in the hypoxic state.

The morphological changes of the alveolar wall of adult rats in the hypoxic state were studied by light and electron microscopy. The remarkable findings were the appearance of a large amount of lamellar, lattice- and thread-like structures together with a massive homogeneous substance on the surface of the alveoli which seemed to be closely connected with each other and with the surface of the cells lining the alveolus, especially in the 5%-group. The appearance of the above-mentioned structures with the homogeneous substance is considered to be the reaction of lung tissue to the decreased content of oxygen in the inhaled gas.

Animals↗
PubMed1983

Renal function study with 111In-DTPA--in comparison with 99mTc-DTPA.

Technetium-99m-diethylene-triamine-penta-acetic acid (DTPA) and 111In-DTPA were injected simultaneously into 21 patients with various levels of renal function. Scintiphoto, camera data renograms and clearance values (plasma sampling) were obtained for each patient. The mixed isotope scintiphoto images were of intermediate quality and the images with 111In-DTPA were apparently inferior to those with 99mTc-DTPA. These equations were obtained: (1) y = 0.30 + 0.91 x (coefficient of correlation r = 0.98) where x is the value at T peak (time of maximum count on renogram) obtained with 99mTc-DTPA and where y is the value at T peak with 111In-DTPA. (2) y = -0.09 + 1.006 x (r = 0.99) where x is the value at T3/4 (time interval between the time of maximum count to the time of 3/4 of maximum count on renogram) and where y is the value at T3/4 obtained with 111In-DTPA. (3) y = -0.01 + 1.007 x (r = 0.98) where the x and y values were for the excretion ratios (counts at 20 min/maximum counts on renogram). (4) y = 0.81 + 0.98 x (r = 0.99) where x and y are the clearance values.

Female↗
PubMedDate not supplied

Comparative study of the efficacy of various moisturizers on the skin of the ASR miniature swine.

The skin of the back of the ASR hairless miniature swine shows a rough and scaly fissured appearance. Clinically it resembles that of ichthyosis vulgaris or senile xerosis in humans. By using the skin of this animal, we developed an assay system to evaluate the efficacy of different moisturizers. The study was carried out in winter months from January to March. To establish this system, we studied various topical agents including such ordinary emollients as petrolatum and 10% salicylic acid in petrolatum as well as those available as pseudodrugs from cosmetic companies or prescription drugs from pharmaceutical companies such as heparinoid- containing creams (w/o and o/w) and 10% urea creams. Applying 0.01 g of each agent to 7 randomly selected skin areas (2x2 cm(2)) on the back of a 6-month-old swine once daily for various periods of time, we measured high-frequency conductance, the parameter for the hydration state of the skin surface. As a result, we have established a simple assay system. It consists of applications of topical agents once daily for 5 days from Monday to Friday in the first week and of subsequent measurement of the skin surface hydration state once every week. Evaluation measurements were performed from day 14 to day 21 depending upon their moisturizing effects. We found that heparinoid-containing creams exerted highly effective moisturizing effects on the dry pig skin that lasted even over 3 weeks after discontinuation of the treatments that were carried out for the first 5 days.

Animals↗