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Biomedical subjects

N Tsuchihashi

Publications and source records attributed to N Tsuchihashi.

At least 37 records · Page 2Linked to original sources
PubMed1994

Evaluation of hearing recovery in patients with sudden deafness.

It is still difficult to evaluate the efficacy of treatment of sudden deafness. Effective methods of therapy have been reported in some studies and other studies have reported spontaneous recovery. In the present study, we assessed the correlation between hearing recovery and various parameters measured during recovery. We used three parameters: hearing gain, relative hearing gain, and recovery rate. We found that the recovery rate during recovery and the parameters measured on the 7th treatment day demonstrated the greatest correlation. The recovery rate on the 7th day of treatment was found to be useful for predicting the final hearing recovery. Comparison of the recovery rate on the 7th day of treatment may be useful for the evaluation of the efficacy of treatment of sudden deafness.

Adenosine Triphosphate↗
PubMed1994

Endoscopic diagnosis of idiopathic perilymphatic fistula.

The usefulness of endoscopic examination for the diagnosis of idiopathic perilymphatic fistula (IPLF) was investigated. Eight patients presenting with unilateral sensorineural hearing loss and vertigo underwent endoscopic examination by the transtubal or transtympanic approach. In 5 out of the 8 patients, transtubal endoscopy was carried out using a superfine flexible endoscope. With this approach, no abnormal findings were visualized. A perilymphatic leak from the round window was observed in 2 patients by means of transtympanic examination using a needle scope. These findings were confirmed in both patients by microscopic observation during tympanotomy. In one patient who was finally diagnosed with IPLF, the transtympanic endoscopy failed to detect perilymphatic leakage. Although incision of the tympanic membrane is necessary for the examination, transtympanic endoscopy is useful for the diagnosis of IPLF. Further improvement of the superfine flexible fiberscope is necessary before transtubal observation of the tympanic cavity can be effectively conducted.

Adult↗
PubMed1994

Idiopathic deafness or hearing loss of unknown etiology following discharge from the NICU.

The clinical course, treatment and respiratory management of 6 infants who developed profound hearing loss (n = 5) or high tone hearing loss (n = 1) some months after discharge from the NICU are presented. All 6 infants had congenital and/or perinatal diseases causing hypoxia, and all were treated with gentamycin. All were nearly normal at discharge but later rose to 80-90 dB, or 60 dB in the case with high tone hearing loss. The hearing impairment was thought to be due to hypoxia, in combination with medications and invasive procedures. Follow-up audiologic testing is recommended after NICU discharge.

Child, Preschool↗
PubMed1994

Rapid free radical reduction in the perfused rat liver.

The reduction of nitroxide free radicals was investigated in detail by Electron Paramagnetic Resonance (EPR) spectroscopy in perfused liver. The nitroxide free radical was rapidly reduced to the corresponding hydroxylamine more efficiently at the lower flow rate of 8 [ml/min], while at higher flow rates, the amount of reduced nitroxide showed a significant decrease. Oxidation of hydroxylamine using hydrogen peroxide provided dynamic information concerning the reduction of the free radical within the liver. In addition, liver homogenates were also investigated to determine the level of nitroxide uptake. The results suggested that a portion of the infused nitroxide was taken up by the liver and cleared from the circulation.

Animals↗
PubMed1994

[Diagnosis of sinusitis in children with allergic diseases--comparison of waters projection radiographs and CT scans].

Sinusitis is common in children with allergic diseases, and the relationship between sinusitis and reactive airway diseases involving asthma has been reported. Most pediatricians and physicians base their diagnosis of sinusitis on findings from plain radiographs of the sinuses, especially Waters projection radiographs. We compared the diagnoses made by 11 pediatric allergists using 56 Waters projection radiographs with transverse CT findings. The ratio for the two diagnosis being consistent (normal plain radiographic findings and normal CT findings, or abnormal plain radiographic findings and abnormal CT findings) was approximately 60%. Sinusitis in children is often misdiagnosed on the basis of findings from Waters projection radiographs alone. Therefore, the use of CT findings for the diagnosis of sinusitis together with Waters projection radiographs is recommended.

Child↗
PubMed1993

Clinical analysis of steroid-responsive sensorineural hearing loss.

In order to clarify general clinical features, characteristics of hearing level fluctuation, and therapeutic strategy in steroid-responsive sensorineural hearing loss, we conducted clinical analysis in the cases which were registered based upon the diagnostic criteria proposed by Kanzaki in 1981. The results obtained were as follows: (1) Disregarding steroid-responsiveness, both ears were impaired in all cases. (2) Female predominance and middle aged onset were found. (3) The underlying immunological abnormality could exist even in the cases without systemic autoimmune disease. (4) The mean incidence in acute hearing change was about once a year in low-frequency area and once 2 years in mid- and high-frequency areas. (5) The mean value of maximum hearing level fluctuation during follow-up period was about 35 dB. (6) The final prognosis of hearing was relatively excellent. (7) By the supplemental administration of Sairei-to for more than 2 years, the maintenance dose of prednisolone was reduced in 80% of the subjects without any significant deterioration of hearing.

Adolescent↗
PubMed1993

Steroid-responsive sensorineural hearing loss: combination therapy with prednisolone and Sairei-to.

We observed cases of hearing loss in which hearing deteriorated when steroid therapy was discontinued and improved upon re-administration. We identified these as cases of steroid-responsive sensorineural hearing loss (SNHL). The diagnostic criteria for determining steroid-responsive SNHL were stated, and 10 cases were examined. The 10 cases of steroid-responsive SNHL were divided into two groups: 3 cases associated with aortitis syndrome (systemic type) and 7 cases with no known systemic disease (localized type). Relatively satisfactory hearing was maintained in these cases by long-term oral administration of prednisolone (PSL). The combined use of Sairei-to made it possible to decrease the necessary maintenance dose of PSL. While the pathology of steroid-responsive SNHL is still unclear, it is suspected that immune complex disease or vasculitis may be involved.

Adolescent↗
PubMed1993

[Congenital nasal stenosis--new concept and its cases].

Congenital nasal stenosis is a new disease concept which was reported, for the first time, by Knegt-Junk et al in 1988. The authors experienced 10 cases of this disease from 1986 to 1990. Radiography revealed that transverse width of the bony nasal passage of these patients was smaller than that of normal infants. Infants with nasal stenosis showed respiratory distress after birth and half of them had a low body weight and/or other congenital defects. Our patients were treated by nasal or oral intubation or by installation of nasal vasoconstrictor into the nasal passage. Four cases showed improvement up to 4 months of age, 6 others after 6 months of age. Tracheostomy was performed in one case. We must differentiate this disease from incomplete choanal atresia or nasal aperture stenosis. Our cases were similar to that of Knegt-Junk et al. We speculate that the congenital origin of this disease stems from a disturbance in embryologic development of the middle third of the face. Accordingly, we measured the diameter of the nasal passage radiography and recognized a narrow transverse width in the bony portion of the nose.

Ephedrine↗
PubMed1992

An ESR-CT imaging of the head of a living rat receiving an administration of a nitroxide radical.

Three-dimensional ESR imaging of a living rat has been performed by an L-band ESR system, which is composed of an L-band ESR spectrometer, a field gradient coil, and a data processor. The imaging was carried out by Lauterbur's method. A nitroxide, 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (Carbamoyl-PROXYL), was used as an imaging agent in saline solution at a concentration of 0.2 M and administered intraperitoneally to obtain a constant concentration in the head for about an hour. It took about 40 min to obtain one set of ESR-CT images. The cross-sectional images were made, both as coronal and horizontal images. In the images of the rat head the nitroxide-rich region was clearly distinguished from the deficient region. The nitroxide-deficient areas corresponded well to the brain of the rat.

Animals↗
PubMed1992

Primary adult T-cell lymphoma of the breast.

A case of primary adult T-cell lymphoma (ATL) of the breast is described. A 69-year-old woman presented with a painless, rapidly growing lump in her left breast. Staging procedures demonstrated no sign of generalized disease. Following a Patey's mastectomy, 10 courses of adjuvant chemotherapy (CHOP) were successfully administered. The light microscopic, immunohistochemical and molecular genetic analyses of the surgical specimen revealed a primary ATL. Seropositive mothers who breast-feed their children may facilitate the accumulation of T cells carrying HTLV-I in their breasts and thereby increase their risks of developing breast ATL.

Aged↗
PubMed1991

Postoperative complications in acoustic neuroma surgery by the extended middle cranial fossa approach.

The complications of acoustic neuroma (AN) surgery by the extended middle cranial fossa approach were studied in 160 cases. Death during surgery occurred in 3 cases (1.9%); 2 of these involved large tumors and the third was a case of recurrence. Transient temporal lobe symptoms were seen in 24 cases (15.3%); the average tumor diameter in these cases was 36.0 mm. Beside symptoms of 7th and 8th nerve disturbance, hemiparesis was seen 7.6%; 3rd, 4th, and 6th cranial nerve symptoms in 7.0%; and cerebellar symptoms in 7.6% of the patients. The incidence of these disturbances increased with tumor size. Cerebrospinal fluid (CSF) leakage occurred in 20.4% of the cases and this necessitated surgical treatment in 5% of the cases.

Cerebral Hemorrhage↗
PubMed1991

Diagnostic procedure for acoustic neuroma.

The authors' diagnostic procedure for unilateral acoustic neuroma and the reasoning behind it are explained. The actual methods involved will change with advances in methodology. At the present time, however, pure tone audiometry and simple radiographic imaging of the internal auditory canal (transorbital and Stenvers View) are first carried out. Then, if the hearing level (average hearing at 4 kHz and 8 kHz) is 70 dB or lower, auditory brain stem response audiometry is carried out. If it is 71 dB or higher, the patient is examined by MRI or CT. Contrast-enhanced CT is carried out when MRI is not available. Air CT is not necessary if MRI is available, but, in cases where hearing preservation is indicated, it may provide valuable information for identifying the tumor site within the internal auditory canal.

Audiometry, Pure-Tone↗
PubMed1991

Progression of hearing loss in acoustic neuromas.

The progression of hearing loss and the factors influencing it are not well understood in patients with acoustic neuroma (AN). We investigated the relationships between the progression of hearing loss and the clinical findings in 42 patients with unilateral AN whose hearing could be examined for a period of 6 months or more. There was a tendency for hearing to deteriorate progressively in the patients with retrocochlear hearing loss, or with a small tumor. Based on these results, we conclude that an operation for hearing preservation should be performed as early as possible in these patients.

Adult↗
PubMed1991

Acoustic neuromas presenting as sudden hearing loss.

Progressive hearing loss is well known as a usually existing complaint in patients with acoustic neuromas. However, sudden hearing loss is also a relatively frequent condition in acoustic neuroma patients. In our review of 132 patients with surgically proven unilateral acoustic neuromas, 29 (22.0%) presented a history of sudden hearing loss. We investigated the clinical and audiological characteristics of these patients, and discuss the etiology of sudden hearing loss in patients with acoustic neuromas. The characteristics of patients with AN presenting sudden hearing loss were as follows: 1) a small tumor, 2) short duration after onset, 3) low incidences of vertigo, dizziness, facial and trigeminal nerve symptoms, 4) the trough type in the audiogram configuration, 5) normal caloric response. Based on the analysis of these results, we conclude that a conduction block of the cochlear nerve is likely to be the etiology of sudden hearing loss.

Adult↗
PubMed1991

Acoustic neuromas with normal hearing.

We report on 10 patients with surgically proven acoustic neuroma (AN) who have normal hearing, and their clinical features have been investigated. The results obtained in this study were as follows: The clinical features of AN patients with normal hearing involved 1) predominance in younger adults, 2) predominance in small tumors with short duration after onset, 3) subjective hearing loss accompanied with tinnitus was the most common symptom, and 4) vertigo or dizziness without any cochlear symptoms was also a frequently seen symptom. We conclude that in order not to overlook AN among patients with normal hearing, transorbital X-ray and ABR tests should be performed on these patients for the screening purpose.

Adult↗
PubMed1990

Effect of viscous indigestible polysaccharides on pancreatic-biliary secretion and digestive organs in rats.

Effects of viscous indigestible polysaccharides on the pancreas exocrine function were investigated in growing rats. Rats were fed a nonfiber diet or a diet containing approximately 5% of one of the following fibers: apple pectin, lambda-carrageenan, locust bean gum, gum xanthan, guar gum or sodium (Na) alginate. Pancreatic-bile secretion was found to be elevated in rats fed for 2 wk the highly viscous polysaccharides, sodium alginate, locust bean gum, gum xanthan and guar gum. The polysaccharides may have interfered with the digestion and absorption of nutrients, resulting in a decreased digestibility and an enlargement of digestive organs. When alginic acid and calcium alginate, insoluble polysaccharides that did not contribute to viscosity, were given to rats, they had no effect on pancreatic and biliary secretion compared with sodium alginate. The results demonstrate that consumption of viscous indigestible polysaccharides leads to changes in the exocrine pancreatic-biliary function and may depress the process of digestion and absorption. Rats may compensate for the inefficiency of digestion and absorption with a hyperplasia/hypertrophy of digestive organs and an increased secretion of digestive juice.

Alginates↗
PubMed1990

[Spontaneous complete remission in a patient with acute monocytic leukemia].

A spontaneous complete remission was observed in a 47-year-old female with acute monocytic leukemia. Resolution of all abnormalities, including systemic papule, thrombocytopenia, increased numbers of immature monocytoid cells in the peripheral blood and bone marrow, elevation of serum lysozyme and LDH, and trisomy 8 on chromosome analysis, occurred without any treatment. Moreover, the remission was not associated with any infection or blood transfusion, and is persistent for 12-month duration.

Chromosomes, Human, Pair 8↗