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N Tsuchihashi

Publications and source records attributed to N Tsuchihashi.

46 records · Page 3Linked to original sources
PubMed1988

Application of the sum peak method to determine the perturbed angular correlation parameters in biological specimens.

The counting rate of a sum peak formed by two gamma-ray emissions in radioactive decay of a nuclide depends on its integral attenuation factor G22. Therefore, in the "sum peak method", the G22 value for the specimen in question can be obtained merely from sum peak measurements using one radiation detector when the resolution time and the geometry are fixed. The procedure to determine the G22 values is described for specimens containing 111In, together with the detailed relationships between the sum peak counting rates and the values of G22.

Animals↗
PubMed1987

Sum peak method applied to the study of human platelet cells.

The sum peak method based on the phenomenon of perturbed angular correlation was applied to study the chemical environments of 111In in intact platelet cells. The sum peak appearing in the gamma-ray spectrum of 111In which emits two gamma-rays in cascade was observed for 111InCl3 solutions and 111In-labeled platelets. An increase in intensity ratios of the sum peak to its single peak was found when 111In incorporated into platelets from its aqueous solution. This fact was discussed in terms of physico-chemical environments of 111In together with an evaluation of sum peak analysis in the spectra.

Blood Platelets↗
PubMed1986

[Clinical studies on T-2588 in the field of otorhinolaryngology].

From clinical studies on T-2588, an oral ester type cephem, the following results were obtained. Ten patients with acute tonsillitis, 3 with acute pharyngolaryngitis, 2 with acute sinusitis, 1 with acute exacerbation of chronic sinusitis and 2 with acute exacerbation of chronic otitis media were treated with T-2588 at a daily dose of 300 or 600 mg. Clinical responses were excellent in 12, good in 4, fair in 1 and poor in 1. Clinical efficacy was 88.9%. Bacteriologically, all isolates except one strain of S. aureus were eliminated. Clinical efficacies classified by clinical isolates correlated well with bacteriological efficacies. The MICs of T-2525 against clinical isolates were determined and compared with those of cephalexin, cefaclor and amoxicillin. The T-2525 showed potent antibacterial activity against Gram-positive and Gram-negative bacteria including S. pneumoniae, H. influenzae and beta-Streptococcus, but the activity of T-2525 against S. aureus was similar to that of the other antibiotics examined. Neither side effect nor abnormal laboratory finding was observed.

Administration, Oral↗
PubMed1984

Effect of indigestible polysaccharides on pancreatic exocrine secretion and biliary output.

The present study was designed to determine the effect of purified viscous polysaccharides on pancreatic exocrine secretion and biliary output. Male Sprague-Dawley rats aged 5 weeks were fed either on the control diet which contained no fiber or on the experimental diets that contained 5% indigestible polysaccharides (agar, kappa-carrageenan, Na-alginate and konjac mannan). After pretreatment with each diet for 2 weeks, the diet was discontinued overnight, and the animals were then allowed to eat 4 g of the test diet in 1 h. Immediately after this, a polyethylene tube was placed in the common bile duct, under anesthesia. Combined, free drained pancreatic-bile juice was collected for the following 1 h. Long-term (2 weeks) administration of Na-alginate and konjac mannan gave rise to increases in the volume of secreted juice and in the output of total bile acids, amylase and protease, whereas that of agar and kappa-carrageenan had no affect. Since a single dose of Na-alginate and konjac mannan was ineffective as regards pancreatic-bile secretion, the elevated secretion observed over prolonged periods may result from processes of adaptation against highly viscous polysaccharides.

Alginates↗
PubMedDate not supplied

An analysis of the intracerebral ability to eliminate a nitroxide radical in the rat after administration of idebenone by an in vivo rapid scan electron spin resonance spectrometer.

Electron spin resonance (ESR) measurements after intracerebroventricular injection of a nitroxide radical were carried out in rats (n = 6) that received oral idebenone for 2 weeks and in control rats (n = 5), using an in vivo rapid scan ESR spectrometer. The half-life of nitroxide, which was estimated from the change in the peak height (delta M = +1) of the ESR signals from the head, was used as a marker for the elimination of the nitroxide radical. The half-life in the rats treated with idebenone was significantly shorter than it was in the controls (p < 0.05). This finding indicates that the treatment with idebenone can enhance the intracerebral-eliminating ability of the nitroxide radical.

Animals↗