Structure of polyether antibiotic A28695B.
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Biomedical subjects
Publications and source records attributed to N Tsuji.
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A newly isolated bacterium which produces antibacterial substances as below was taxonomically characterized and identified with Corynebacterium equi. The major antibiotic produced was determined to be hygromycin by direct comparison. The minor component, newly named epihygromycin was proved to be an epimer of hygromycin by spectrosocopic evidences and by chemical conversions. The presence of epihygromycin in the metabolites of Streptomyces noboritoensis (reported to be a hygromycin producer) was also observed.
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In addition to trichostatins A and B, a new antifungal antibiotic, trichostatin C was isolated. The structure was shown to be a glucoside of trichostatin A by spectroscopic examinations and chemical degradations. Trichostatin C is presumably the first example of a glucopyranosyl hydroxamate from nature.
A new antibiotic, trichostatin, was isolated from the metabolites of strains of Streptomyces hygroscopicus. It is active against trichophytons and some fungi. The structure was determined to be a derivative of a primary hydroxamic acid by chemical and spectroscopic evidences.
Two new antibiotics, A-218 and K-41, were isolated from strains identified as Streptomyces hygroscopicus. The antibiotics are characterized as polycyclic polyether compounds and are active against gram-positive bacteria.
New antibiotics, griseusins A and B were isolated from a strain of Streptomyces griseus. Both antibiotics have a 5-hydroxy-1, 4-naphthoquinone chromophore and their molecular formulae were determined to be C22H20O10 and C22H22O10, respectively. The griseusins are active against gram-positive bacteria.
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