Active immunization with a glycolipid transition state analogue protects against endotoxic shock.
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Animals↗
Biomedical subjects
Nicholas A Boyle
Publications and source records attributed to Nicholas A Boyle.
Formats for combinatorial synthesis: solid-phase, liquid-phase and surface.
Methods for combinatorial and parallel synthesis continue to evolve in order to meet the demands of modern synthetic organic chemistry. The nature of the support, while typically overlooked, is a key consideration for successful combinatorial organic synthesis. Developments in combinatorial synthesis technologies such as the 'lab-on-a-chip' concept and 96-well-plate-compatible resin plugs have been reported, which should contribute to meeting the increasing challenges of this field.
Combinatorial Chemistry Techniques↗
Peptidomimetics and peptide backbone modifications.
The replacement of the amide bond in a peptide backbone is a widely used form of peptide mimicry. Several of the most common amide bond surrogates, including peptidomimetic work done in this laboratory, and their biological applications are presented in this review.
Amino Acids↗