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Biomedical subjects

O A Dada

Publications and source records attributed to O A Dada.

43 records · Page 3Linked to original sources
PubMedDate not supplied

Effect of chronic chloroquine treatment on prostaglandin and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat testis.

The effect of chronic chloroquine administration on prostaglandin E1 (PGE1) and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat Leydig cells was studied. Adult albino (Wistar strain) rats were injected with 4 mg/kg body weight of chloroquine phosphate every other day for 30 days. At the end of the period of treatment, the rats were sacrificed and the Leydig cells incubated with hCG and/or PGE1 for 3 hrs. The amount of testosterone secreted was estimated by radioimmunoassay. Chronic chloroquine treatment did not affect the activity of the Leydig cells and combined PGE1 and hCG did not show any additive effects.

Alprostadil↗
PubMedDate not supplied

Chloroquine excretion in semen following antimalarial-drug administration.

The study described here was carried out to establish whether or not chloroquine was excreted in semen. Chloroquine was assayed in the semen of eight male volunteers (aged between 19 and 45 years) by a fluorimetric method before and after taking a total dose of 1.500 mg chloroquine base corresponding to the accepted dosage of the drug in malarial chemotherapy. Mean pre- and post-drug administration levels of 0.7 +/- 0.2 microM and 5.7 +/- 0.6 microM were obtained respectively, indicating a significant excretion of chloroquine in semen.

Adult↗
PubMedDate not supplied

Chloroquine reduces fertilizing capacity of epididyma sperm in rats.

Chloroquine diphosphate was administered intraperioneally to two groups of adult male rats at two dosage levels of 5 mg base/kg body weight and 10 mg base/kg body weight. The drug was administered over a period of fourteen days. Fertilizing ability of epididymal sperm was assessed in the rats by cohabitation with normal cycle female rats and foetal size was noted. Epididymal spermatozoa were counted in these groups of rats. Chloroquine effected a dose-related reduction in fertility of the male rats as evidenced by a reduction in average number of foetuses of cohabited females, although the sperm count in the groups was not significantly different. This suggest that the drug does play an inhibitory role in sperm function.

Animals↗
PubMedDate not supplied

The effect of thyroid hormones on the membrane adenylate cyclase activity in sickle red blood cells in vitro.

A comparative study of thyroid hormone responsive membrane adenylate cyclase activity has been carried out on normal (Hb-AA) and sickle cell (Hb-SS) subjects. Thyroid hormones (T3 and T4) and selected analogues (TRIAC and DLT) enhanced adenylate cyclase activity in Hb-AA membranes. The interaction of Hb-SS membranes with the hormones and analogues was not significant except for T3 which moderately stimulated Hb-SS membrane adenylate cyclase. We suggest that circulating irreversibly sickled cells, in view of their membrane phospholipid defect, probably contribute to the low response of membrane adenylate cyclase to effector stimulation.

Adenylyl Cyclases↗
PubMedDate not supplied

Endocrine function and haemoglobinopathies: biochemical assessment of thyroid function in children with sickle-cell disease.

Thyroid function was assessed in ninety children with homozygous sickle-cell disease (haemoglobin genotype SS) in forty-five children with heterozygous sickle-cell trait (AS) and in 162 control children with haemoglobin genotype AA. Serum levels of thyroxine, the in vitro triiodothyronine resin uptake and the calculated index of 'free thyroxine' were not significantly different in the three groups. The distribution of individual thyrotropin (TSH) values showed that only 11% of the HbSS subjects had values below the 95% confidence limits for the HbAA controls. However, the mean level of TSH was significantly lower in the HbSS than the other two groups of children.

Adolescent↗