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Biomedical subjects

O C Mungiu

Publications and source records attributed to O C Mungiu.

At least 19 recordsLinked to original sources
PubMed1991

Bioactive polymers 54. Pharmacological properties of modified neomycin.

Modified neomycin prepared by the ionic coupling on xanthan with an activity of 380 UI/mg was characterized in regard to its in vitro and in vivo release rate and therapeutic action with artificial tear eluent. The dynamic system in vitro release showed that after 4 h, there appears a "zero-order" kinetic. Ophthalmic inserts were prepared from modified neomycin and they are used in treating bacterial conjunctivitis. Sterilization of the conjunctival sac is obtained 12 h after insert administration.

Conjunctivitis, Bacterial↗
PubMedDate not supplied

[The action of xanthinol nicotinate on the central and peripheral arterial pressure and on respiration in dogs].

The pharmaceutical trial in dogs on the influence the Romanian pharmaceutical product xanthinol nicotinate has on the cardiovascular system (central and peripheric blood pressure, venous pressure, EKG) and respiratory system rendered evident a hypotensive effect in direct ratio to the dose, prevalently peripheric, without significant changes in respiratory amplitude. It is concluded that the Romanian product has similar effects to those described in the literature for xanthinol nicotinate.

Animals↗
PubMedDate not supplied

[The evaluation of the teratogenesis and embryotoxicity of the pharmaceutical product Boicil tablets. I. The effect of the pharmaceutical product Boicil tablets on fertilization and implantation in rats and mice].

The teratogen action of Boicil tablets was studied in two animal species, rats and mice, the prefertilization and implantation stages being the main interest. Three generations of animals were followed up. The active powder suspended in distilled water (0.1 ml/10 g for mice and 1 ml/100 g for rats) was administered per os in a single dose, prepared on spot and in two doses, 2 mg/kg body weight and 20 mg kg body weight, respectively. The administered doses were equivalent to the daily maximum therapeutic dose prescribed in humans (110 mg active principle). The first gestational day was determined differently in the two species. For estimating the effect on prefertilization, Boicil tablets was administered for 5 days before making and for its effects on the number of implantations during the first 3 gestational days. The two parameters under investigation were within normal limits and all newborn animals followed up for three generations did not present pathological microscopic and gross alterations or somatic malformations. It was concluded that Boicil tablets is not teratogenic.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

[The evaluation of the teratogenesis and embryotoxicity of the pharmaceutical product Boicil tablets. II. The effect of the pharmaceutical product Boicil tablets on early embryogenesis, organogenesis and the fetus in 3 successive generations of rats and mice].

The effect of Boicil tablets on early embryogenesis (the first 3 gestational days), organogenesis (the 10th, 11th and 12th gestational days) and fetus (the 18th and 19th gestational days) by its intraamniotic administration was followed up in three successive generations of mice and rats. Two doses were used (2 mg/kg body weight and 20 mg/kg body weight), estimated in relation with the maximum therapeutic daily dose in man, being administered in a single dose, per os. No inborn malformations or somatic abnormalities were recorded both in mothers and in their descendents for three successive generations. It is concluded that Boicil tablets is not teratogenic.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

[Adhesive cutaneous pharmaceutical forms].

The adhesive cutaneous pharmaceutical forms aimed to local action release the drug substance in view of a dermatological, traumatological, antirheumatic, cosmetic action. Two such preparations were obtained and their stability, consistency and pH were determined. The "in vitro" tests of their bioavailability revealed the dynamics of calcium ions release according to the associations of each preparation. The bioavailability determined by evaluating the pharmacological response demonstrated the antiinflammatory action obtained by the association of calcium ions with the components extracted from poplar muds. The therapeutical efficiency of the studied preparations has proved in the treatment of some sport injuries.

Adhesives↗
PubMedDate not supplied

[Comparative clinico-therapeutic study of amitriptyline hydrochloride (Tryptizol/amitriptyline)].

As compared to the psychopharmacological profile of amitriptyline hydrochloride the authors analyse the findings of a comparative clinical trial amitriptyline versus Tryptizol regarding their efficacy in neurotic and presenile depression. 170 inpatients divided into four comparative series were investigated. The drugs were administered according to the same scheme in monotherapy for 30 days. The efficiency and tolerance of these drugs were estimated through clinical observations, the recording of the first ameliorated state and the maximum one, psychological check-up by using Hamilton's scale for depressions, paraclinical investigation, recording of side effects, clinical and paraclinical screening for 0-10-20-30 days. The analysis of clinical findings in the investigated series reveals for both drugs their easy administration, tolerance, incidence and low intensity of the side effects. The comparative estimation of the treatment with amitriptyline and Tryptizol in neurotic and presenile depressions attests a similar therapeutic efficiency.

Adolescent↗
PubMedDate not supplied

[The cutaneous bioavailability of alpha-chymotrypsin from ointments].

In view of improving the cutaneous bioavailability of alpha-chymotrypsin from ointments, the stability of this enzyme in two hydrophile ointment bases, macrogoli and carbopol, was tested. The cutaneous bioavailability of alpha-chymotrypsin in ointments, estimated by determining the anti-inflammatory action, underlines the important role played both by the ointment base and by the enzyme activating substances. By correlating the determinations of alpha-chymotrypsin enzymatic activity with the anti-inflammatory action a correlation between the manifested activity and the active substance stability was noticed.

Animals↗