PubMed Health⌕ Search

Biomedical subjects

O Faergeman

Publications and source records attributed to O Faergeman.

At least 55 records · Page 3Linked to original sources
PubMed1988

Pharmacokinetics of xamoterol after intravenous and oral administration to patients with chronic heart failure.

The pharmacokinetics of xamoterol, a beta-adrenergic partial agonist under clinical evaluation for the treatment of mild to moderate heart failure, have been studied in 8 cardiac failure patients (NYHA Class II) of mean age 62 years. After i.v. dosing, the elimination half-life was 7.4 +/- 0.4 h, the total body clearance was 228 +/- 30 ml.min-1 and the volume of distribution at steady-state was 56 +/- 9 l. 72.5 +/- 4.3% of the dose was recovered unchanged in urine. After the oral dose, the absolute bioavailability of xamoterol was shown to be 5.9%. Peak plasma concentrations occurred 1 to 2.5 h after the oral dose. The apparent elimination half-life was significantly longer after oral doses (16 +/- 2 h) compared to that observed after an intravenous dose. Renal clearance of xamoterol exceeded glomerular filtration rate as measured by creatinine clearance. The pharmacokinetics of xamoterol in cardiac failure patients with good renal function (creatinine clearance greater than 90 ml.min-1) were similar to published data in young healthy male volunteers.

Administration, Oral↗
PubMed1988

Effects of soy protein and casein in low cholesterol diets on plasma lipoproteins in normolipidemic subjects.

Dietary plant proteins may lower plasma cholesterol and LDL concentrations in hypercholesterolemic patients when substituted for animal proteins, particularly in diets with low cholesterol and saturated fat content. Plant protein diets appear, however, to be without effect on plasma lipoprotein levels in normal subjects. In the present study, we have examined whether the origin of the dietary protein, i.e. plant (soy) or animal (casein), affects the plasma lipoproteins in normolipidemic subjects when these proteins are presented as components of diets low in cholesterol and saturated fat. The study followed a crossover design. Five men and 5 women consumed liquid formula diets containing 20% of calories as casein or soy protein, 28% as fat (mainly monounsaturated), and 52% as carbohydrate; the intake of cholesterol was less than 100 mg per day. The two dietary periods, each of 1 month duration, were separated by an interim period of 1 month on self-chosen food. Following an initial 30% reduction of cholesterol and LDL plasma levels on both diets, the concentrations of each of the major lipoprotein classes (VLDL, IDL, LDL, HDL2 and HDL3) were similar during the two experimental dietary periods. Body weights were essentially constant. Dietary soy protein and casein could not be distinguished in their effects on the plasma concentrations and chemical composition of the major lipoprotein classes in normolipidemic subjects.

Adult↗
PubMed1988

The long-term effect of alprenolol on plasma apolipoproteins A-I and B.

The concentration of lipids, lipoproteins and apolipoprotein A-I and B was measured in the plasma of 33 patients, enrolled in a double-blind, controlled trial of alprenolol in myocardial infarction, after one year on the study medication and again after 6 months off the medication. Sixteen patients received 200 mg alprenolol twice daily and 17 received placebo. There were no statistically significant differences between the parameters in the two groups after one year on medication. However, when medication was stopped, the ratio of apolipoprotein B to apolipoprotein A-I fell by 9% in the alprenolol group and increased by 2% in the placebo group. This difference was statistically significant. Our results suggest that alprenolol, a beta-blocker with weak intrinsic sympathomimetic effect, has slight effects on plasma lipoproteins. These effects were apparent only by measurements of apolipoproteins.

Adult↗
PubMed1987

Multicenter, double-blind comparison of doxazosin and atenolol in patients with mild to moderate hypertension.

In a double-blind multicenter study, the new alpha 1-adrenoceptor inhibitor doxazosin was compared with atenolol for efficacy, safety and effect on serum lipids. One hundred and twenty-six patients with mild to moderate hypertension were randomly assigned to receive either doxazosin (n = 63) or atenolol (n = 63). The mean final dosages, administered once daily, to obtain 24-hour blood pressure (BP) control were doxazosin 12 mg (range 1 to 16) and atenolol 91.8 mg (range 50 to 100). Of 12 doxazosin and 7 atenolol patient withdrawals from the study, 7 doxazosin and 4 atenolol patients withdrew for treatment-related reasons. No statistically significant differences between treatment groups were found after 20 weeks in changes from baseline in standing and sitting BPs measured 24 hours after administration. Sitting BP (systolic/diastolic) was reduced by 10.5/9.8 mm Hg after doxazosin treatment and by 10.9/10.7 mm Hg after atenolol therapy. Standing BP was reduced by 8.8/7.7 mm Hg after doxazosin administration and 9.7/9.3 mm Hg after treatment with atenolol. Supine BP was measured in a small cohort of the study population, and doxazosin had a smaller effect than atenolol. After 20 weeks of treatment, both drugs reduced heart rate with atenolol producing a statistically significantly greater decrease than doxazosin (standing, doxazosin 5 beats/min, atenolol 16.2 beats/min, p less than 0.001; sitting, doxazosin 5 beats/min, atenolol 13.1 beats/min, p less than 0.001). Side effects were reported by 37 patients receiving doxazosin therapy and 34 patients receiving atenolol therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenergic alpha-Antagonists↗
PubMed1985

High-carbohydrate, low-fat diet: effect on lipid and carbohydrate metabolism, GIP and insulin secretion in diabetics.

The effects of increasing the dietary polysaccharide content from the customary 40 percent to 50 percent of total energy intake were examined in a metabolic ward-cross-over study of eight noninsulin dependent diabetic patients with normal fasting C-peptide concentration. The aim was to study the effect of a raised carbohydrate content; therefore, the fibre content of the diet was kept approximately constant. Patients had been treated with diet alone, and the high carbohydrate (HC) observation period lasted for two weeks. Blood glucose was significantly increased postprandially in the HC period (11.8 +/- 0.3 versus 10.7 +/- 0.4 mmol/l), and this was accompanied by significantly raised immunoreactive insulin (IRI) concentrations. The secretion of IRI, C-peptide and gastric inhibitory polypeptide (GIP) after a standard meal-challenge at the end of each period were unaffected by the preceding diets. The HC diet was accompanied by increasing values of plasma triglyceride (1.13 +/- 0.06 versus 0.97 +/- 0.06 mmol/l) and VLDL-triglyceride (0.69 +/- 0.04 versus 0.50 +/- 0.04 mmol/l), whereas the ketone body concentration was decreased (0.25 +/- 0.03 versus 0.36 +/- 0.05 mmol/l). Both HDL- and LDL cholesterol were decreased by the HC-diet (1.07 +/- 0.02 versus 1.18 +/- 0.02; 3.45 +/- 0.09 versus 3.89 +/- 0.09 mmol/l, respectively), while the LDL to HDL cholesterol concentration ratio remained unaffected. Thus, in two weeks, a HC diet resulted in hyperglycaemia, hyperinsulinaemia, hypertriglyceridemia and a state of antiketogenesis, without any apparent change in the capacity of mealinduced insulin release. LDL- and HDL-cholesterol were lowered to the same extent.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

Serum lipoproteins after treatment with verapamil for 6 months.

Fasting levels of serum lipids and lipoproteins were measured in survivors of acute myocardial infarction after 6 months of treatment with placebo (n = 19) or verapamil 360 mg daily (n = 13). There were no significant differences between the groups and values had not changed in the verapamil group 2 weeks after cessation of treatment.

Adult↗
PubMed1982

Effects and side-effects of partial ileal by-pass surgery for familial hypercholesterolaemia.

Ten patients with familial hypercholesterolaemia were subjected to partial ileal by-pass surgery. Plasma cholesterol fell by 41 and 38% and low-density lipoprotein cholesterol by 51 and 46% after six and 18 months respectively. High-density and very low-density lipoprotein cholesterol and plasma triglycerides were unaffected. Alanine aminotransferase increased transiently in half of the patients. Diarrhoea and slight steatorrhoea troubled most of the patients for the duration of 18 months' period of observation. Other long-term side effects were slight but significant increase in the renal excretion of oxalic acid and reduction in the intestinal absorption of calcium. The study shows that this operation has metabolic side-effects that warrant continued medical care of these patients.

Adult↗