[Nursing care for the child who has heart disease].
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Child↗
Biomedical subjects
O H Kim
Publications and source records attributed to O H Kim.
Ossification in a soft tissue embryonal rhabdomyosarcoma.
We describe the previously unreported finding of ossification within a rhabdomyosarcoma of the extremity in the absence of bone destruction. Rhabdomyosarcoma is a highly malignant tumor but could not be radiographically differentiated from benign or other malignant causes of soft-tissue masses containing calcium. Definitive diagnosis and thus appropriate therapy requires prompt pathologic examination.
Female↗
Delayed sternal ossification in infants with congenital heart disease.
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Child↗
A case of congenital hepatic fibrosis: usefulness of hepatobiliary scintigraphy.
A case of operatively proven congenital hepatic fibrosis was studied by scintigraphy with Tc-99m-phytate and Tc-99m-Pl (a hepatobiliary radiopharmaceutical). Two focal defects were recognized in the liver on the colloid liver scintigram. Ultrasound and contrast angiography suggested that the two focal defects were cystic lesions. Radionuclide hepatobiliary imaging was performed with Tc-99m-Pl, since intravenous cholangiography was unsatisfactory. One focal defect was proved to be a dilated intrahepatic bile duct and another was found to be cyst. Radionuclide hepatobiliary imaging with Tc-99m-Pl proved to be very useful in identifying dilated intrahepatic bile ducts in this patient as well as in following the progress of this disease.
Adult↗
[A survey on mother's attitude toward weaning].
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Age Factors↗
US in the diagnosis of pediatric chest diseases.
Most pediatric chest diseases are adequately evaluated with chest radiography. However, when chest radiography does not allow identification of the location and nature of an area of increased opacity, ultrasonography (US) can help establish the diagnosis. US may be helpful in evaluation of persistent or unusual areas of increased opacity in the peripheral lung, pleural abnormalities, and mediastinal widening; US is particularly useful in patients with complete opacification of a hemithorax at radiography. In cases of pulmonary parenchymal lesions, identification of air or fluid bronchograms at US and of pulmonary vessels at color flow imaging is useful for differentiating pulmonary consolidation or atelectasis from lung masses and pleural lesions. US allows characterization of pleural fluid collections as simple, complicated, or fibroadhesive, which is important information for planning thoracentesis or thoracotomy. Computed tomography and magnetic resonance imaging are superior to US in evaluation of the mediastinum, but US is a reasonable alternative in certain situations (eg, to avoid unnecessary investigation of a normal thymus simulating a mediastinal mass). In cases of chest wall lesions, US may enable localization of the site of origin to soft tissues or an extrapleural intrathoracic location. Osseous involvement, particularly rib involvement, is easily evaluated with US.
Adolescent↗
Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin.
The c-erbB-2 oncogene encodes a tyrosine kinase that constitutes the internal and transmembrane part of the epidermal growth factor receptor (EGFR). ErbB-2 overexpression has been reported in 20% to 30% of human adenocarcinomas of the breast and ovary, and has been linked to an unfavorable prognosis in patients. Hypericin is a protein tyrosine kinase inhibitor that has been exploited in models for anti-tumor and anti-viral activity. In this study, we investigated the effects of hypericin on the activity of the c-erbB-2 oncoprotein and its downstream kinases. We also investigated the effect of hypericin on metastasis. We used ovarian SK-OV-3 cells as a model to determine whether hypericin-induced cell death was associated with inhibition of c-erbB-2 expression and activation. The IC50 of hypericin after 72 hrs exposure was 7.5 microM as determined by the MTT assay. Apoptosis, which was assessed by morphological changes and a flow cytometric assay, was observed at 24 h after continuous exposure to 5 microM hypericin. Inhibition of expression of the c-erbB-2 protein was detected, using a monoclonal anti-erbB-2 antibody after 12-48 hrs of exposure to hypericin. Hypericin was found to inhibit autophosphorylation of the erbB-2 protein and downstream kinases such as MEK and ERK1/2. We also found up-regulation of p21WAF1 expression and down-regulation of Bcl-2 in hypericin treated cells. An invasion assay showed that hypericin inhibited the movement of SK-OV-3 cells into the Matrigel. However, gelatin zymography showed that hypericin had no effect on the secretion of matrix metalloproteinases (MMPs) in SK-OV-3 cells. From these results, we conclude that hypericin inhibits the growth of SK-OV-3 ovarian cancer cells, inhibits the autophosphorylation of c-erbB-2, induces apoptosis, and may inhibit invasion.
Anthracenes↗