Biomedical subjects

O Regius

Publications and source records attributed to O Regius.

23 records · Page 2Linked to original sources

PubMedDate not supplied

The effect of smoking on the presence of antinuclear antibodies and on the morphology of lymphocytes in aged subjects.

The effect of smoking on the presence of antinuclear antibodies and on the occurrence of mitochondrial changes in lymphocytes was studied in 518 subjects over 45 years of age without overt diseases. Antinuclear antibodies could be demonstrated more frequently in smokers than in non-smokers. Smoking did not influence the age dependent degenerative changes in the mitochondria of the lymphocytes, but giant mitochondria could be seen more frequently in smokers than in non-smokers.

Aged↗

PubMedDate not supplied

[Active immunization against tick-borne encephalitis in the elderly].

30 healthy young persons and 19 healthy aged people (between 60-75 years) were vaccinated against tick-borne meningoencephalitis virus. The antibody production of the young people was compared to that of the aged ones following vaccination. It has been found that the antibody production of the aged people was delayed, and more elderly people than young ones showed an increase of the IgM-bearing lymphocytes after vaccination. The morphological changes of the circulating lymphocytes were identified with electron microscope. The presence of cytoplasmic inclusions called parallel tubular arrays could be observed in the course of immunization. The inclusions were not found before vaccination, and it is suggested that the inclusions are related to the in-vivo antigen stimulation.

Adult↗

PubMedDate not supplied

[Antibody-dependent cytotoxicity capacity of healthy women and men in old age].

The authors studied the ADCC capacity in 42 healthy aged persons. The Bakács-Garam Test were used. The allogen and the xenogen systems were investigated, with the mentioned methods. The authors concluded that the above mentioned tests gave good results in the xenogen system, too. Using the Bakács-Garam Test the results were the same in both systems, therefore they are comparable. According to these results, authors concluded, that there is no substantial difference between ADCC capacity of healthy aged men and women.

Aged↗

PubMedDate not supplied

Gender differences in age-related physiological changes and some diseases.

The clinical and laboratory data from a cross-sectional and a longitudinal study of healthy individuals between 50-89 years of age and that of centenarians were compared. The examination showed that in healthy elderly subjects and centenarians most of the clinical laboratory findings were in the normal range. However, age-related changes could be observed in erythrocyte sedimentation rate, in serum albumin level, and in the frequency of rheuma factor. Gender difference could be seen in the HDL-cholesterol level. Age and sex differences were observed in the hematocrit-, and hemoglobin-values, in serum creatinine-, total cholesterol-, serum IgG, IgA, IgM-levels, and in the frequency of the occurrence of antinuclear factor. The examinations demonstrated that lower hemoglobin and hematocrit values, elevated total-cholesterol level, the presence of antinuclear and rheuma factor, and elevated systolic blood pressure were more frequent in females than in males. It could be stated, however, that the mentioned changes did not prevent females from having a longer life span than males.

Aged↗

PubMedDate not supplied

[Extended family, immediate family and caregiver contacts of 100-year-old patients in Hungary].

In the year 1987, 218 centenarians lived in Hungary. First the main demographic data were reported by the surveyors of the Central Statistics Office. The basis of the experience was gained on a limited population (123 subjects). The physicians' team was organized by the Gerontology Center of the Semmelweis University of Medicine. They carried out the detailed medical and environmental check-up. The medical and environmental experiences of the gerontologists were published (1). In our present paper we would like to show the different familial and other relationships of the oldest people. The 123 centenarians were scattered over the whole country, altogether in 67 larger or smaller settlements. More of them lived with a daughter (42%), with a son (14%), with a grandchild (7%), with other relatives (5%) and 3 persons lived together with their wives. We found that the subjects who lived with relatives had a better chance to live an active and meaningful life. The co-existence of several generations, the multilateral contacts of centenarians have a beneficial effect on the quality of life.

Activities of Daily Living↗