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Biomedical subjects

O Staindl

Publications and source records attributed to O Staindl.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Remote flap transplantation using microvascular anastomosis for scar correction (author's transl)].

The method of tissue displacement from a donor region to a receiving area with the help of microvascular anastomosis represents a synthesis of the traditional classical remote flap graft and free tissue transplantation. The method of defect replenishment with the help of a freely transplanted skin-fat-connective tissue flap from the groin region (groin flap) is demonstrated by the example of a correction of a shrinking scar on the neck of a 21-year-old patient, and the anatomical basis and operation technique are described. The advantages and disadvantages of the method are discussed.

Adult↗
PubMed1981

The influence of fibrin stabilization and fibrinolysis on the fibrin-adhesive system. A clinical study using radioactively marked fibrinogen as a tracer.

In many fields of surgery the use of highly concentrated human fibrinogen, which forms a fibrin clot when thrombin is added, is gaining increasing importance for tissue adhesion. A number of experimental and clinical reports on fibrin sealing have been published during recent years. The question underlying our present investigations is as follows: What happens to the tissue adhesive after its application to a wound in clinical use, i.e., how much time is required for complete resorption of the seal due to fibrinolytic processes? Skin graftings of the face (required to close defects caused by the excision of basal or spinal cell carcinomas) were performed by glueing rhomboid flaps or full thickness skin grafts to the wounds with the tissue adhesive to which 125I-marked fibrinogen has been added. Activity counts were recorded daily and CPM were plotted versus time to obtain summation curves. The physiological processes of fibrin stabilization and fibrinolysis are extensively discussed as both factors influence the tissue adhesive and thus have to be accounted for in clinical practice.

Aged↗
PubMed1981

[The vascular pattern in solid and cystic basal cell tumors (author's transl)].

In addition to other criteria, the growth pattern, macroscopic form, and histologic examination of a tumor are heavily influenced by the tumor's blood supply. Rapid size increases of basal cell carcinomas in certain of our patients has led us to examine the capillary network of such tumors. Known histologic patterns were summarized, and the tumor vascular patterns evaluated by scanning electron microscopy of corrosion preparations. For this, an artery leading to the tumor was cannulated, and a thin synthetic resin ("Mercox" liquid) injected. After precipitation, the preparation was macerated in aqueous sodium hydroxide. The vascular changes encountered could thus be illustrated in three-dimensional form. In addition to changes specific in the tumors (i.e., caliber fluctuations, cyst formation at vessel ends, and degeneration forms), peculiar formations could be found in various sites, suggesting that capillary neogenesis was taking place within the tumors.

Capillaries↗
PubMed1980

[Correction of prominent ears (author's transl)].

The the last 20 years plastic surgery was increasingly concerned with the correction of prominent ears. It is not possible to exactly define this anomaly, since it is not only subject to certain tangible criteria from a medical point of view, but also to the purely personal, esthetic perception of the patient. In the present publication an attempt is made to make a broad classification of those factors which together result in the impression of too prominent ears. There are basically 3 techniques for correcting this anomaly: 1. simple suture techniques, 2. simple section techniques, 3. combined techniques. The publication deals specifically with one operation-technique. It is basically a modification of the "Stenstroem-Anthelix-plastic;; procedure. This technique is indicated in the case of uncontoured, flatly prominent ears, whereby the correction is achieved by creating an anthelix bulge. An instrument which we developed as well as our dressing technique are described. Finally, the 123 operations which we carried out according to this technique between 1975 and 1979 are critically assessed.

Adolescent↗
PubMed1980

[Experimental heterograft tracheal transplants in animals. III. Light microscopic, scanning and electron microscopic findings (author's transl)].

In seven three-month old piglets, tracheal defects were created experimentally and Cialit-fixed human tracheal transplants were grafted at the site of the defect. The implants did well in five of the animals, and no signs of respiratory insufficiency (such as stridor, dyspnea or cyanosis) were found. 230-273 days after the transplantation, the animals were sacrificed and the tracheas removed. The transplants were then examined macroscopically and by light, scanning and transmission electron microscopy. Two questions arose: 1) What was the fate of the epithelium of the tracheal graft? It was then found that the host tracheal epithelium surrounding the graft resurfaces the graft. However, a series of morphological changes occur and are described in detail. 2) What happens to the grafted tracheal cartilage? It was found that the cartilage was replaced by thick connective tissue and scar. From the results of these studies, two conclusions could be drawn. 1) The repair of tracheal defects by means of Cialit-fixed human tracheal grafts is limited in those cases in which the newly formed connective tissue is not able to stabilize the tracheal tube. 2) The size of the heterologous tracheal transplant is limited to 6-7 cm2 in animal experiments.

Animals↗
PubMed1980

[Dogbite-lesions of the face (author's transl)].

The present paper deals with dogbites and their operative treatment as it is being carried out at our Department. One can distinguish the following three forms of injuries, which each require a different surgical approach. 1. Simple bites which merely show the bite channels of the teeth and tissue contusions can be left to spontaneous healing. 2. Extended fissures and tear injuries require primary plastic-surgical treatment which is described in detail. 3. Bites with tissue loss: the wound is initially covered with a superficial epithelial bandage; subsequently, plastic-surgical treatment with defect reconstruction according to the local requirements and with due regard to esthetic aspects is necessary. Two case reports illustrate the exposition. The necessity of rabies prophylaxis, tetanus inoculation, and antibiotic treatment during the postoperative phase is stressed.

Animals↗
PubMed1980

[The rhomboid flap: fundamentals for technical planning, variations and clinical applications (author's transl)].

The rhomboid flap was initially described by Limberg and was later modified by Dufourmentel as well as by a number of American clinicians. The flap can be an effective method for closing facial skin defects with good color and texture matches. Although the flap requires geometric planning, a minimum of scarring is possible by creating "zig-zag" lines in relaxed skin tension lines after closing the defect. Details of variations of the flap and their practical uses are described.

Adult↗
PubMed1979

[Sudden deafness (author's transl)].

"Sudden deafness" is understood as an instant loss of the hearing ability meaning a sensorineural hearing loss of one or both ears which can lead to total deafness. Suitable measures for treatment of sudden deafness are vasodilatation by infusions of Complamin (Lamuran, Dusodril, Rheomacrodex), blockage of the ganglion stellatum, hospitalizations of the patient to protect him from psychogenic stress factors and prescription of sedatives. From 1973 to 1977 84 patients with sudden deafness were treated at the ear, nose and throat department of the Landeskrankenanstalten Salzburg. Only 2 patients were under 20 years of age, 53 (62.3%) were between 20 and 50, and 29 (34.5%) over 50 years old. In 60.6% of the cases an improvement of the hearing ability by 20 db to normal could be achieved, 39.4% did not show any positive therapeutic results.

Adult↗
PubMed1979

The healing of wounds and scar formation under the influence of a tissue adhesion system with fibrinogen, thrombin, and coagulation factor XIII.

The present paper reports the central role of fibrin (and specifically its pre-stage, fibrinogen), thrombin and coagulation factor XIII in wound healing and scar formation. The significance of these three factors had led to the development of a tissue adhesion system on a physiological basis, which can be applied in widely varying areas of surgery. The adhesive allows the exact, flat adaptation of the wound edges and thus promotes flawless scar formation. Two case reports complete the exposition.

Accidents, Traffic↗
PubMed1979

[Experimental heterograft tracheal transplants in animals. II (author's transl)].

In sequence with an earlier publication on the results of heterograft tracheal transplants in animals, changes in the Formol-Cialit preserved heterogenous tracheal grafts were studied by light microscopy, and by scanning and transmission electron microscopy. Two main queries arise. Where does the graft respiratory epithelium come from, and what happens to the grafted tracheal cartilage? We found that in the epithelium of graft the number of ciliated cells decreased and that there was ultrastructure evidence of cilial destruction, the goblet cells increased in number, there was a loss of strict polarity of the respiratory epithelium, subepithelial accumulations of cells of probable epithelial origin appeared, and there was a subepithelial accumulation of lymphocytes just beneath the basal lamina. Resorption and transformation of the grafted tracheal cartilage into connective tissue was also observed. Hence, the following conclusions may be made. (1) Small tracheal defects can be corrected by Formol-Cialit preserved heterologous grafts. (2) The mucosa of the host trachea produces a functioning respiratory epithelium in the graft. (3) Tracheal grafts should not exceed 2 x 3 cm in size otherwise a new stenosis from resorption and transformation of grafted cartilage into connective tissue will occur.

Animals↗
PubMed1979

[The pathogenesis of tracheal stenosis following thyroidectomy (author's transl)].

The frequency of trachealmalacia or stenoses following operations for struma or recurrent struma initiated our study of the pathogenesis of such changes. This study revealed that mechanical factors, such as compression of the trachea and the like, had been reported in the literature as the causative factors. The present paper investigates to what extent disturbances in the blood supply of the trachea, particularly after ligature of the inferior thyroid artery during thyroidectomy, influence changes in the tracheal mucosa, the connective tissue, and the adjacent cartilage. In twelve experiments on domestic pigs, the blood supply of the cervical trachea was interrupted. After varying periods of survival time, the animals were sacrificed and the tracheas histologically examined. In all cases, ischemic changes in the tracheal mucosa and cartilage could be found in addition to inflammatory reactions with scar formation. It seems justified to conclude that both mechanical factors and disturbances in local blood supply can cause tracheal tissue changes after thyroidectomy. The inferior thyroid artery and its branches also seem to play a central role in the success or failure of tracheal reconstructions following end-to-end anastomoses after stenosis resections. As a consequence, this paper also deals comprehensively with the detailed anatomy of this vessel.

Adult↗
PubMed1979

[Results of heterologous tracheal transplants in animal experiments (author's transl)].

In the present study, 7 x 15 mm Cialit-preserved human tracheal segments were grafted to the tracheas of five 3-month old piglets. 72-120 days later, the animals were sacrificed and the grafts with proximal and distal control areas were removed. Tissues were then examined macroscopically and by light and scanning electron microscopy. We found that: (1) all grafts had taken well; (2) no animal suffered from clinical signs of respiratory obstruction or inflammation; (3) although luminal diameters of the tracheas increased from 8 mm to 22 mm, the size of the grafts remained unchanged but the resulting tracheal stenosis did not cause respiratory obstruction; (4) the graftet areas showed re-epithelialization. The nature of the re-epithelialization as well as the fate of the submucosa and tracheal cartilage will be reported in a subsequent publication.

Adult↗