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Biomedical subjects

O V Reshetnikov

Publications and source records attributed to O V Reshetnikov.

24 records · Page 2Linked to original sources
PubMed1994

[The characteristics of duodenogastric reflux in peptic ulcer and chronic gastritis].

Patients with gastroduodenal ulcer, chronic gastritis (CG) and healthy controls (124, 57 and 24 subjects, respectively) were examined for intensity and duration of duodenogastric reflux (DGR). These indices were assessed by concentrations of gastric juice bilirubin. It is found that DGR occurred in 29% of the examinees free of gastroduodenal diseases, does not correlate with morphological CG-induced changes and Helicobacter pylori contamination degree. The reflux in CG seems to be secondary in pathogenesis of this disease. In patients with aggravated duodenal and gastric ulcer the reflux in the basal stage is 2-2.5 and 5-6 times higher than in the controls, respectively. DGR parameters correlated with the height of the ulcer defect. Retrograde entrance of the duodenal content into the stomach in duodenal ulcer enhances acid production in the stomach through gastrin mechanisms.

Adolescent↗
PubMedDate not supplied

[The prevalence of helicobacteriosis in regions of Siberia based on serological study data].

687 adults in 5 regions of Siberia and 79 children and young persons in Novosibirsk were examined. IgG antibodies to H. pylori in their blood sera were determined with the use the enzyme immunoassay. The detection rate of antibodies among the adult population varied within 70-87%, depending on the region, being somewhat lower among the population north of latitude 60 degrees (75%) in comparison with the population residing south of this latitude (86%, p < 0.001). In Novosibirsk the number of seropositive persons was found to be unrelated to sex, age and clinical manifestations of digestive tract diseases. A high detection rate of antibodies to H. pylori was registered in persons aged 25-34 years with a minor increase in older age groups. In children the detection rate increased with age: 29% in children of 5-10 years old and 56% in children 11-14 years old. By the age of 15 more than a half of the children had antibodies.

Adolescent↗
PubMedDate not supplied

[Prevalence of Helicobacter pylori CagA-producing strains within families].

During prophylactic examination of blood sera taken from the members of 59 families by the enzyme immunoassay, antibodies to H. pylori and CagA protein were determined. As shown in this study, the children of non-infected mothers proved to be infected in 6.3% of cases and the children of infected mothers, in 72.1% of cases (p < 0.001). The children of non-infected fathers were H. pylori-positive in 71.4% and those of infected fathers, in 58.4% of cases. The CagA status was found to coincide in mothers and their children (p = 0.01), but not in fathers and their children. These data indicate that children acquire H. pylori infection from the members of their family, mainly from their mothers.

Adolescent↗
PubMedDate not supplied

[Morphofunctional correlations in chronic gastritis].

A significant correlation between a number of functional parameters of gastric secretion, incretion and histological changes of gastric mucosa was found in patients with chronic gastritis. Score assessment of morphological abnormalities of the gastric mucosa allows using not only simple statistical methods, but also complex mathematical models.

Adolescent↗
PubMedDate not supplied

[Determination of prostaglandin contents in gastric juice].

Gastric juice prostacyclin and thromboxane were radioimmunoassayed in patients with chronic gastritis and peptic ulcer and in normal subjects. Prostanoid secretion into the gastric lumen was found to reflect the degree of inflammatory changes in the gastric mucosa.

Chronic Disease↗