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Biomedical subjects

O V Siniachenko

Publications and source records attributed to O V Siniachenko.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

[Changes in the dynamic surface tension of the blood and urine during the development of visceritis in patients with rheumatoid arthritis].

The condition was studied of the dynamic surface tension of biologic fluids in patients with rheumatoid arthritis using a method of maximum pressure in the vesicle with the aid of computerized tensiometer MPT-1 "Lauda" (Germany). Rise in indices of blood serum surface tension with diminution of the slope of tensiogram curves may suggest the development of pathology of the heart and liver, while increase in the same parameters of urine might be indicative of the coming nephropathy.

Adolescent↗
PubMedDate not supplied

[The blood level of nitric oxide metabolites in experimental autoimmune disease during immunosuppressive therapy].

Experimental autoimmune disease causes a drastic increase in the production of nitric oxide metabolites. The latter correlate with the indices of autoimmunity expression, with the levels of cyclic nucleotides, with the severity of morphological impairment of the structures of immunocompetent organs. The use of immunosuppressive agents in the pathogenetic therapy of an autoimmune process normalizes both the blood levels of nitrites/nitrates and immunological parameters; this reflects a clear-cut relationship between the synthesis of nitric oxide and the immune response of the body.

Animals↗
PubMedDate not supplied

[The organizational and methodological aspects of teaching student interns clinical nephrology].

The analysis is given to experience in teaching clinical nephrology to subinterns at a therapeutic chair. The initial knowledge in nephrology assessed in undergraduates proved unsatisfactory. Guidelines are presented for lecturers as well as results of questioning surveys of the students. The students answers showed that individual clinical tasks appeared most difficult for them. The mean score fr home tasks was 3.1, good marks being given in 21% only. Poor knowledge was reported in resolving diagnostic questions, treatment of renal failure, treatment of the kidneys in systemic disorders of the connective tissue. The post-study test control stated considerable gain of relevant knowledge.

Internship and Residency↗
PubMedDate not supplied

[Roentgenologic assessment of articular lesions in rheumatoid arthritis].

The article presents a comparative analysis of methods for quantitative assessment of roengenologic changes in the joints in rheumatoid arthritis that have come to be widely used in USA and Europe. It is noted that the Steinbroker's method widely employed by clinicians fails to give an integral assessment of the articular affection. Expediency is documented of employment of the Sharp's method in roentgenologic monitoring in clinical trials of new antirheumatic drug preparations. In a routine clinical setting the Larsen's method or its modifications are to be preferred since in spite of its low sensitivity investigation time is cut down 2.3-fold by comparison with the Sharp's method.

Arthritis, Rheumatoid↗
PubMedDate not supplied

[Genetically determined gout: characteristics of the course].

Analysis of clinical-roentgen-laboratory features of the course of hereditarily determined gout in 74 patients is represented. It is exhibited that hereditarily induced gout begins at the young age and is accompanied by the acute disturbance of purine exchange resulting in serious relapsing course of the articular (with availability of radiological attributes of osteal destruction) and the renal syndromes (urate nephrolithiasis, immune complex glomerulonephritis, tubulointerstitional nephritis) as well as in the early occurrence and rapidly progressing chronic renal insufficiency. The disease is accompanied by high frequency of the cardiovascular pathologies negatively influencing the mean lifetime of patients.

Adult↗
PubMedDate not supplied

[Sex hormones in podagra].

Male patients with gout exhibit a decrease in the blood content of testosterone and estradiol and an increase in the content of progesterone. The amount of androgen and estrogen changed insignificantly but the level of gestagen abruptly dropped in female patients. Irrespective of the sex the concentration of lutropine and follitropine appeared to be decreased. Whereas the level of uric acid in men was in inverse relation to the production of estradiol, in the group of women--to the indices of progesteron. Changes in sex hormones depended on the form of arthritis and the type of nephropathy.

Adult↗
PubMedDate not supplied

[Chondrocalcinosis in gout].

Problems of pathogenesis, diagnosis and therapy of gout and chondrocalcinosis in which deposits of uric acid salts and calcium are found in the articular tissue are of primary importance in modern rheumatology. The authors give observations of 10 out of 218 patients with primary gout in whom roentgenology had revealed signs of calcium salt deposits in the joints and periarticular tissue.

Adult↗
PubMedDate not supplied

[Effect of allopurinol on the indicators of immunity in podagra and experimental hyperuricemia].

The authors studied the immunity indices in patients with gout against the background of a long-term (one year) therapy with allopurinol, and in animals with experimental hyperuricemia. During treatment the authors observed normalization of blood immunoglobulin M level, a considerable decrease in circulating immune complexes and anti-renal antibodies, a tendency to a rise in the function of T-lymphocytes, great enhancement of the activity of polymorphonuclear phagocytes in tests with Staphylococci and nitro-blue tetrazolium. Mechanisms of action of the given drug are discussed.

Adult↗
PubMedDate not supplied

[Anti-deoxyribonucleic acid antibodies in podagra].

Antibodies to native (n) and denatured (d) DNA were studied in 70 patients with primary gout and 40 experimental animals with hyperuricemia. Titres of anti-nDNA in patients with gout considerably exceeded similar indices in donors and were in inverse relationship with the severity of arthritis and markedness of morphological manifestations of renal affection. Anti-nDNA directly correlated with the count of B-lymphocytes in the blood and indirectly with other immunological indices. Anti-dDNA directly correlated with the count of B-cells, reaction of lymphocytes to Kon-A and the titres of antirenal antibodies but were in inverse relationship with the content of uric acid and IgG in the blood serum. Long-term feeding of rats with yeast autolysate with ammonium molybdate and inosine was accompanied by the development of hyperuricemia, an abrupt drop in the level of DNA in the plasma and by a rise in the level of anti-DNA antibodies.

Adult↗