Alpha-tocopherol acetate produced a positive effect on the renal function in patients with nephrogenous hypertension due to replenishment of endogenous antioxidants and its regulatory effect on lipid peroxidation. As a result there occurs a reduction of highly-toxic products of lipid peroxidation, improvement of renal microcirculation, reduction of ischemic disorders in the organs of the body.

Antioxidants↗

PubMedDate not supplied

[Immune disorders in osteoarthrosis in miners].

An immunologic evaluation was done in healthy miners and those working in coal mines suffering from deforming osteoarthrosis. Blood levels of beta 2-microglobulin and circulating immune complexes, titres of antibodies to glycosaminoglycans and antigens from cartilaginous tissue and synovial membrane were all found to be elevated. Shifts in the immunity system were clearly related to the spread of the pathological process as well as the rate of the disease progression and presence of reactive synovitis but not with occupation of the patients. Clinico-immunologic manifestations of osteoarthrosis were unfavourably influenced by industrial mining-geological factors.

Antibodies↗

PubMedDate not supplied

[Sex and gonadotropic hormones in the blood in joint diseases in miners].

Coal miners suffering from rheumatoid arthritis (RA), deforming osteoarthrosis (OA) and gouty arthritis (GA) were found to develop hypotestosteronemia in a study on the condition of the hypophysis-and-gonads system, this being observed even in essentially healthy individuals. With all arthronoses, androgen levels get depressed, particularly so in the presence of increased activity of lutropin. In RA examenees blood concentration of estradiol tends to increase, while OA and GA miners demonstrate reduced content of estrogen, with manifest hyperprogesteronemia being common. Hormonal dysbalance correlates with gravity of the course of the inflammatory-degenerative processes in the locomotor system.

Arthritis, Gouty↗

PubMedDate not supplied

[The dynamic surface tension of the blood and urine in chronic glomerulonephritis].

Dynamic surface-tension (S-T) was investigated of blood and urine of healthy individuals and patients with chronic glomerulonephritis by the proposed method of maximum pressure in a bubble with the aid of the computer-assisted device tensometer MPT-1 (Lauda, Germany). Patterns of changes in dynamic and static S-T were found out as were those of the slope of the curve in patients with mesangioproliferative and mesangiocapillary variants of the condition, in nephrotic syndrome and chronic renal insufficiency. Correlation type comparison was performed of physical-and-chemical properties of biological fluids to parameters characterizing protein and fat exchange. Relationship between dynamic S-T and biochemical composition of blood and urine was revealed. Diagnostic value of results of the studies made is discussed.

Adolescent↗

PubMedDate not supplied

[Biogenic amines in rat brain structures in an adjuvant arthritis model].

The role of changes in biogenic amines neurochemistry in cerebral structures in abnormal immunoreactivity accompanying development of autoimmune disease was investigated in experiments on 24 Wistar male rats. Biogenic amines and their metabolites (dopamine, dioxyphenylacetic acid, serotonin, oxyindolacetic acid) were assays in the sensomotor cortex, hypothalamus and hippocamp by means of high-performance liquid chromatography. Development of adjuvant arthritis was associated with definite neurochemical changes in the brain: inhibition of serotonin metabolism and enhancement of dopaminergic systems in the hypothalamus and sensomotor cortex. Prophylactic administration of oil solution D,L-alpha-tocopherol acetate promoted enhancement of serotonin metabolism in hypothalamic and hippocampal neurons. Bitemporal exposure to UHF electric field aroused stronger effects on the neurochemical metabolism in hypothalamic, hippocampal and sensomotor cortex neurons than TPA. It is concluded that bitemporal exposure to UHF electric field and antioxidant activate central immunoreactivity mechanisms in animals with adjuvant arthritis. Serotonin and dopamine systems in this process are leading.

Animals↗

PubMedDate not supplied

[Effect on cardiac function of altered adenosine metabolism in rat brain structures in modelled hyperuricemia].

Experiments on 24 Wistar male rats were performed to clarify the role of central mechanisms in the onset of electrical instability of the heart due to disturbances in purine metabolism. The activity of the enzymes responsible for synthesis and conversion of adenosine-5-nucleotidase and adenosine deaminase in the sensomotor cortex, hypothalamus and hippocamp was studied. Changes in cardiac function were most severe in high levels of adenosine in the neurons of the sensomotor cortex, hypothalamus and hippocamp. Minimal changes occurred in low content of adenosine in the hypothalamus and hippocamp.

Adenosine↗

PubMedDate not supplied

[Dynamic interphase tensiometry of the cerebrospinal fluid and blood serum in nervous system tumors].

Dynamic superficial tension (ST) of spinal fluid (SF) and blood serum in patients with CNS tumors was investigated. The maximum bubble tension was measured by a MPT2 computer tensiometer (LAUDA). There were decreases in ST of blood serum at t = 1 and t-->infinity, increases in ST at t = 0.01 and decreases in the angle on SF tensiograms. The parameters of interphasic tensiometry of the biological fluids depend on content of biologically active substances severity of the neurological symptomatology and duration of disease. Successive surgical treatment is followed by normalization of SF and blood serum ST.

Adolescent↗

PubMedDate not supplied

[Changes of respiratory function in patients with rheumatoid arthritis and systemic lupus erythematosus during complex therapy].

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Adolescent↗