Biomedical subjects
Publications and source records attributed to P A Chumachenko.
Laser iridotherapy was carried out simultaneously with irradiation of immuno-competent zones on the integument of the human body in patients with stomach and duodenal ulcers. As a result of such treatment, it was discovered that laser therapy has immunomodulating action leading to the reduction of the ulcer cicatrisation period.
Reduction of the incidence of postoperative hyperthyroidism (POH) is one of the urgent problems of DTG surgery. According to Soviet authors, it reaches 48%. The authors take into account a complex consisting of the patient's age, the degree of thyrotoxicosis, and the results of emergency (intraoperative) histological study. A program was elaborated with due consideration for adequate preoperative examination, preparation of the patients for the operation, a standardized method with reliable determination of the mass of the thyroid residue, morphometric examination of the removed part of the thyroid, study of the late-term results and their comparison with the preoperative clinical picture. Intraoperative determination of the percentage of active zones and the presence of intrafollicular epithelium and lymphoid infiltration made it possible for the authors to reduce POH incidence from 43.5% to 2.8%.
A method for modeling of strangulation ileus consisting in passing the intestinal loop through a strip of cycle rubber nipple with a diameter of 2 mm, width of 4 mm is suggested. Advantages of the method were confirmed by the findings of angioscopy and morphologic study in ileus modeling in 175 rats. The method suggested permits easy and prompt creation of a standard model of strangulation ileus in rats in all the cases, and study after the nipple transection of the changes characteristic of the postischemic period.
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The contributors provide research data on the clinical manifestations, secretory and pepsinogenous function, morphological and histologic structures of stomach diseases caused by local vibration induced vibration disease. A correlation was established depending on the duration of work. As a result of clinico-functional and morphologic techniques used, no full correlation was traced between the stomach structure and function in VD patients, which seem to be of practical value for medical examination of workers engaged in unfavorable working conditions.
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The presented method of breast treatment, used in a total histologic study, allows one to avoid freasing microtome for large sections, hence, deformation of histologic structures. In cases, when breast consists mainly of fatty tissue, it is impossible to obtain histotopographic sections. The presented scheme of tissue treatment involving standard sledge microtome, acetone, thermostat heat provides 25-35 micron sections. The method can be widely used by pathologists for total histotopographic study of the organ.
A new method of preparation and embedding the mamma from mature and elderly women has been suggested for the total histologic study. Acetylcellulose obtained from safety film (used for x-ray, cinema and photography) was used as an embedding material instead of celloidine that is not readily available. The method suggested can be widely applied both for research, and practical activities of pathoanatomists in total histotopographic study of the organ.
An analysis of the morphofunctional relationships between hypophysis and female mammary gland is performed in 146 patients aging between 8 and 25 years. Both organs are studied using various histological, histochemical, morphometric and statistical methods. It is established that hypophysis influences actively on the mammogenesis not only in the incipient (12-16 years) and late (22-25 years) periods of sexual maturation but at other age periods as well. However the degree and character of this pituitary influences on the mammary gland are not the same this being shown by the results of a correlation analysis of relationship between pituitary and mammary gland indices. This seems to be due to both a direct and indirect influence of pituitary hormones on the mammogenesis as well as to the individual variability of mammary gland responses on the mammogenic effects. In rare cases mammary gland reacts on the ordinary hormonal stimulus by the development of pathological process.
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The observation of parathyroid adenoma in a 65 year-old man is described. The tumour consisted of main parathyroid cells followed by primary parathyrosis with calcareous metastases in many organs, mainly in the myocardium, resulting in a heart failure.
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By means of a developed method of histotopographical sections cartograms, 146 preparations obtained from female persons at the age of 8-25 years have been studied. The organ is intensively developing not only at 12-16 years of age, but at 22-25 years, as well. A close correlation is noted at 10-11 years of age between the mammary gland mass and the degree of its parenchyma (glandular tree) development. Subsequently, the connection between these indices becomes essentially weaker. At the age of 15-25 years, according to the variability and standard deviation quantile classes reflecting stages in the organ formation (the degree of the glandular tree development), five types of the mammary gland are distinguished: weak, low middle, middle, high middle and high. During transition of the mammary gland from the weak to the high type, at first the glandular tree is intensively developing in the periphery and in the internal parts, and then in the external squares and in the center of the organ. The degree of uneven development in the glandular tree increases when the middle type is reached. Subsequently, it decreases up to the initial level.
An integrating index for the evaluation of the functional state of the thyroid gland is described. The calculation of the index is based on a conditional 6-score evaluation of morphometric characteristics of the thyroid gland. The index is a product of the mass of epithelium reflecting the number of working elements and the height of epithelium of the thyroid gland follicles describing the intensity of thyreocytes functioning. The possibility of using this index is substantiated.
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