[Influence of administration of glucose and/or insulin on the mechanical and metabolic activity of the isolated heart in newborn lambs].
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Biomedical subjects
Publications and source records attributed to P Castelli.
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The authors report their experiences in two kinds of late complications of direct reconstructive surgery: infections and anastomotic false aneurysms. Such complications occurred after operations calling for the use of alloplastic prostheses, with an incidence of 2.8% out of all other operations in which prosthesic grafts have been used. All the patients have undergone second surgery with good results in 16 cases out of 19 (84.3%), 1 patient underwent amputation (5.2%) and 2 patients, suffering for infected false aneurysms of the aorta, died (10.5%).
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Juxtarenal aortic occlusion is one of the most important though less frequent atherosclerotic lesions. The indications for surgical treatment using bypass techniques, are well known. However, controversy remains about the pathogenesis of the lesion; from either a thrombosis developing on an atherosclerotic lesion of the terminal aorta, or a primary atherosclerosis of the subrenal aorta. In our series of 1,180 patients submitted to surgery for aorto-iliac occlusive disease, we encountered 91 cases (7.7%) of juxtarenal occlusion. Apart from the different angiographic pictures, the patients were grouped on the operative finding of either thrombosis or atheroma. An aortobifemoral bypass graft was implanted on all but three of the cases; in these three we performed an axillo-bifemoral bypass. A different technique was used, for juxtarenal disobliteration, using a different (end-to-end, or end-to-side) suture of the proximal anastomosis. The operative indications and results are discussed.
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The authors describe six subjects with Reye's syndrome. All subjects died nevertheless the treatment (exchange-transfusions infusions of citrulline and ornithine). The autoptical studies showed cerebral oedema and fatty degeneration of the liver. Hepatic and seric OTC activity was measured in three patients: enzyme activity was virtually absent in one patient and normal in the other two. Instead in one patient was found partial CPS deficiency. However, Reye's syndrome is not only correlated with enzymatic deficiency of urea's cycle but sometimes also with toxic and metabolic causes.
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The author indicates the importance in varicose veins of involvement of the external saphenous, making clear the distinction between sapheno-popliteal ostial insufficiency without varices and venous insufficiency with varices. He recommends a surgical approach determined on the basis of good clinical examination and appropriate supplementary examinations: such surgery should always be followed by sclerotherapy.