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Biomedical subjects

P Charters

Publications and source records attributed to P Charters.

At least 19 recordsLinked to original sources

Acute airway obstruction due to ruptured aneurysmal arterio-venous fistula: common carotid artery to internal jugular vein.

Fistulae between major vessels in the head and neck are uncommon. In both civilian and wartime reports, the total number of traumatic arterio-venous fistulae in head and neck region account for less than four per cent of all arterial injuries. Fourteen cases of congenital communication between the external carotid artery and external or internal jugular vein have been reported. We report and discuss the management of a case of ruptured carotico-jugular fistula secondary to infection which presented as acute upper airway obstruction. This appears to be the first description of such a case in the literature.

Aged

Analysis of mathematical model for osseous factors in difficult intubation.

A two-dimensional model of the factors relevant to difficult laryngoscopy was analysed mathematically to determine clinical implications and limitations. The model describes the space into which the "inevitable residual volume" of the tongue (that part remaining anterior to the blade at laryngoscopy) can be displaced to permit a view of the larynx. Four points are used: the tip of the upper incisors; a point on the anterior airway just above the larynx; the mid-point between the mandibular condyles and the internal mid-point of the symphysis. The number, F, was defined by a formula developed from their spacial relationships. Decreasing F values imply an increasing likelihood of difficult laryngoscopy. The analysis investigated the effects of: translation of individual points; plotting individual point positions for specified F-values; translating adjacent pairs of points; treating any three points as a triangle which rotates about each of its apices; and lastly, translating three points independently. During manipulations the model behaved well mathematically. Single point analysis implied that jaw recession and a non-protruding mandible were comparable in effect. Closing the mouth around the laryngoscope blade maximised F-values. Prominence of the maxilla required greater forward displacement than backward movement of the symphysis for equivalent F-value change. One particular triangular rotation suggested an entirely novel mechanism for difficulty (the "hi-slung mandible") where the condyles are positioned more rostral than normal. An otherwise normal jaw with this configuration recedes markedly on opening. Further studies are required to validate the model. Accurate quantification of individual factors in difficult laryngoscopy may then be feasible.

Adult

Cuffed nasopharyngeal tube as 'dedicated airway' in difficult intubation.

A cuffed nasopharyngeal airway was used in five cases of difficult intubation, initially to maintain anaesthesia, and subsequently to act as a landmark for the passage of a fibreoptic laryngoscope loaded with a tracheal tube. In all cases, airway patency was well preserved with the device and there were no significant problems with its use. The notion of a 'dedicated airway' for difficult intubation cases is developed. A trouble-free airway will permit time to consider solutions for difficult cases and time for the novice to learn fibreoptic laryngoscopy technique.

Anesthesia, General

An analysis of laryngoscope blade shape and design: new criteria for laryngoscope evaluation.

Laryngoscope blade design has tended to be relatively arbitrary and so far scientific analysis has not allowed useful comparisons between blade shapes. A new theoretical method of analysing laryngoscope blades is introduced and uses the depth of insertion profiles of two angular measurements. One represents eyeline displacement and the other the forward space that the blade occupies at the level of the mandible. Photographs of straight and curved blades were studied on Cartesian graphs with the tip T, at the origin and handle fittings parallel to the x-axis of the graph. Then, IT is any line from the origin to the incisor surface and represents a point of contact with the upper incisors for a given depth of blade insertion. Angle EIT (eyeline displacement) is to a tangent from I along the lower lingual surface of the blade. Point M is on the upper lingual surface of the blade, at right angles to IT, 1/3 of the distance from I along IT. Angle MIT (forward space) may be positive or negative depending on whether M is in front of or behind IT. The angles EIT, MIT and their additive combination are used in blade analysis. Negative MIT compensates for eyeline displacement as Macintosh size 3 and 4 blades have better combination scores than Miller size 3. All three are superior to the straight Soper size 3 blade. The Macintosh size 1 and 2 blades are quite different from the larger Macintosh blades. This theoretical basis for blade analysis is consistent with commonly expressed clinical opinions and may influence blade design in the future.

Equipment Design

The role of mucosal receptors in the nasal sensation of airflow.

50 subjects were admitted into a randomized double-blind placebo controlled cross-over trial with 4% lignocaine as the active drug and normal saline as the placebo. Each subject had 2 ml of solution sprayed into each nasal cavity and all subjects had both sprays but on different occasions. The order in which the sprays were administered was randomized. The subjective sensation of nasal airflow was measured using a visual analogue scale before and after the spray. These measurements were made under conditions of the same airflow rate, which was monitored throughout the experiment using a reprogrammed NR6 rhinomanometer. Objective nasal patency was measured as peak nasal inspiratory flow rate. It was found that the nasal sensation of airflow decreased slightly after both lignocaine (difference between medians 5.0; 95% confidence interval -2.91 to 6.11) and normal saline (difference between medians 6.0; 95% confidence interval -1.02 to 7.21). Nonparametric analysis of variance showed this difference to be non-significant (P = 0.73). In addition there was no significant change in objective nasal patency. The results suggest that nerve endings in the nasal mucosa play no part in sensing nasal airflow during respiration.

Adolescent

The objective assessment of nasal patency.

Nasal patency was measured by five techniques in 24 subjects and the results compared. In addition three pulmonary parameters were measured as well as height and weight. Nasal resistance to airflow measured by active anterior rhinomanometry was found to be highly correlated with peak nasal inspiratory flow rate. Other correlations were also noted. Peak nasal inspiratory flow was itself highly correlated with pulmonary peak expiratory flow rate as well as with several other parameters. The possible reasons for these correlations are discussed in terms of fluid mechanics.

Adult

Pivoting larynx--an unusual clinical observation at laryngoscopy.

Rigid oesophagoscopy was planned in the investigation of a young patient with dysphagia. During laryngoscopy for tracheal intubation an unusual pivoting manoeuvre was required to see the vocal cords. Although the initial diagnostic investigations were unhelpful, follow up directed at explaining the clinical observations led to an eventual diagnosis of anterior tubercles of C6, which explained the observation and accounted for the dysphagia.

Adult

Factor analysis in difficult tracheal intubation: laryngoscopy-induced airway obstruction.

We have studied eight patients with a history of difficult tracheal intubation, using x-ray laryngoscopy and local anaesthesia, a curved Macintosh blade and a standard intubating position. The view obtained was better than recorded previously during general anaesthesia in two patients, and in a third the x-ray showed that positioning the blade tip beneath the epiglottis would have improved vision, suggesting that reproducibility of the assessment may not be consistent. The "ease of intubation" and "complementary" angles may be helpful in the assessment of such patients. A "peardrop" effect is described whereby during laryngoscopy, the epiglottis became pressed against the posterior pharyngeal wall as a result of tongue compression. In the absence of muscle paralysis, removal of the blade caused immediate correction. However, during anaesthesia with neuromuscular block it is suggested that this not only occurs more readily but, may not correct when the blade is removed. Iatrogenic airway obstruction during moderately difficult tracheal intubation may be common and should be anticipated.

Airway Obstruction

Factor analysis in patients with a history of failed tracheal intubation during pregnancy.

Eight patients with a history of failed tracheal intubation during pregnancy were investigated by x-ray laryngoscopy after delivery. Partial elevation of the epiglottis with no view of glottic structures was found in five patients who were therefore considered to still present difficulty. In each of these five patients the blade tip failed to make contact with the hyoid and in four this was explained by the tongue being compressed into a pear shape such that it prevented sight of the larynx. Relatively few abnormal anatomical indices were seen in these patients and this was in keeping with the level of difficulty encountered. An angular measure of jaw protrusion from a line joining the upper incisors and a point just above and anterior to the vocal cords, to the mid-point on the inner surface of the mandible was useful: the lower angle of this triangle was as important as the angle at the incisors.

Adult

Defining a standard intubating position using "angle finder".

Study of patients who exhibit only limited morphological abnormality yet present difficulty with direct laryngoscopy is facilitated by a standard intubating position. The "Angle Finder" instrument allows implementation of a simple reproducible geometric standard which is applied easily in formal research work and in clinical practice and teaching. The proposed standard relates to the curved (Macintosh) laryngoscope blade and a supine patient. The lower neck flexion is 35 degrees and extension of the plane of the face 15 degrees, each angle measured relative to horizontal. Initially, the standard was derived from a review of the literature, then validated in a study of the intubating practices of 10 senior anaesthetists. A more detailed study of 10 normal volunteers confirmed reproducibility and, for nine patients with a history of difficult direct laryngoscopy, the standard was shown to be appropriate.

Head

Disposition of cervical vertebrae, atlanto-axial joint, hyoid and mandible during x-ray laryngoscopy.

Ten healthy volunteers underwent direct laryngoscopy using topical anaesthesia and a curved Macintosh laryngoscope blade. A lateral x-ray was performed during laryngoscopy in a standard intubating position. In this position the lower neck was relatively straight and increasing curvature occurred from the mid cervical spine upwards. Extension at the atlanto-axial joint was probably near maximum; this has implications for conditions associated with laxity of this joint. The position of the mandible was influenced by the direction of pull on the laryngoscope handle. The hyoid was drawn forward and its body tilted downwards so as to lie halfway between the lower border of the mandible and the glottis. The relative length of epiglottis projecting above the hyoid was variable.

Adult

An additional tactile test. Further developments in tactile tests to confirm laryngeal placement of tracheal tubes.

An additional clinical test to confirm laryngeal placement of tracheal tubes is described. Using the new test, placement was confirmed in all of 50 patients studied in whom difficulty would have been anticipated using previously described tactile tests (male patients with lower molar teeth). Two anaesthetists with small hands averaged 98% confirmations in two series each of 100 consecutive unselected intubations. A simple modification of the tests enables their application after nasotracheal intubation; even with small hands, a confirmation rate of 96% in 50 consecutive cases was found. The three tactile tests are reviewed and analysed. In the authors' combined experience of 14 cases of difficult laryngoscopy the tests gave reliable confirmation in 12 patients. Familiarity with these tests is stressed to be important for their reliable implementation.

Adult