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Biomedical subjects

P E Andersen

Publications and source records attributed to P E Andersen.

105 records · Page 6Linked to original sources
PubMed1979

[Bilateral fusion of the lesser multangulum (trapezoid) and the capitate in Turner's syndrome (author's transl)].

Fusion of the carpal bones, especially the lesser multangulum (trapezoid) and the capitate, are rare. Fusion of the lunate and triquetrum, however, are more common and are more frequent in negroes than in caucasians. The patient presented had Turner's syndrome, retarded bone age and shortening of the fourth metacarpals. Etiology, pathology, symptoms and possible relation to Turner's syndrome are discussed.

Adolescent↗
PubMed1978

Pulmonary abnormalities in mitral valve disease. Comparison between pulmonary wedge pressure, regional pulmonary blood flow and chest films.

Chest films, right sided heart catheterization, and measurement of the regional lung perfusion, using 133Xe, were carried out 31 times on patients with mitral valve disease. A relationship was found between the radiologic evaluation in 3 grades, and the values of pulmonary wedge pressure and the apical and basal perfusion. Changes in flow distribution as reflected in altered appearance of the vessels and the presence of interstitial edema were found to be the most sensitive factors in the evaluation of pulmonary wedge pressure. Chest radiography was thus found suitable for the evaluation of pulmonary wedge pressure in mitral valve disease.

Adult↗
PubMed1975

Blood-brain transfer of d-glucose, l-leucine, and l-tryptophan in the rat.

Recently Oldendorf developed a method for measurement of the early uptake of substances from the capillary bed into brain tissue after a single capillary passage of a bolus injected rapidly into the common carotid artery of the rat. The uptake of a test substance is expressed relative to the uptake of a highly diffusible reference substance, tritiated water. In this study experimental data are presented allowing to correct the uptake values for the unknown loss of tritiated water, so that the fractional unidirectional uptake (Extraction, E) can be calculated. This method is used to investigate the uptake kinetics for D-glucose, L-leucine, and L-tryptophan. For the three substances investigated the uptake kinetics involved both saturation and linear kinetics. Km values of 11 mM for D-glucose, 0.16 mM for D-glucose, 0.16 mM for L-leucine, and 0.19 mM for L-tryptophan were found. The uptake capacity, Vm, was calculated using a blood flow value of 0.85 ml/(g x min); Vm was for D-glucose 1.6, for L-leucine 0.027, and for L-trytophan 0.024 mumol/(g x min). The D-glucose Vm in the present study is comparable with Vm values in the literature, and indicates that the method may be employed for quantitative analyses of the blood-brain transfer of solutes.

Animals↗
PubMedDate not supplied

Inadvertently performed hysterosalpingography during early pregnancy.

A review of 6,225 hysterosalpingographies disclosed four cases of inadvertently performed examinations during early pregnancy. These radiologic misadventures were in three cases performed because of oligomenorrhoea and in one case because of a misjudged decidual bleeding. The radiologic findings and the outcome of these pregnancies are presented. Precautions to avoid this radiographic error are discussed.

Abnormalities, Radiation-Induced↗
PubMedDate not supplied

Bilateral femoral head dysplasia and osteochondritis. Multiple epiphyseal dysplasia tarda, spondylo-epiphyseal dysplasia tarda, and bilateral Legg-Perthes disease.

Multiple epiphyseal dysplasia tarda (MEDT) and spondylo-epiphyseal dysplasia tarda (SEDT) are genetically transmitted conditions affecting the hips, which may resemble bilateral Legg-Perthes disease (LPD). Misdiagnoses are not uncommon, with serious implications for treatment, prognosis and genetic counseling. An epidemiologic study of MEDT and SEDT in a well-defined population of 453,921 persons in Denmark was performed. A population prevalence of 0.7 per 100,000 inhabitants with SEDT and 4.0 per 100,000 inhabitants with MEDT was found. Distinguishing features between MEDT, SEDT and bilateral LPD based on radiologic findings in the hips, other joints, and spine were ascertained. Bilateral LPD is always asymmetric, exhibits patches of increased density in the epiphyses and often metaphyseal cyst-like changes. No spinal lesion or affection of other joints is present, and the acetabula are normal. In MEDT and SEDT the capital femoral epiphyses are symmetrically flattened, fragmented and uniformly slightly sclerotic. Generalised platyspondyly is a constant finding in SEDT.

Adolescent↗