Biomedical subjects

P Holch

Publications and source records attributed to P Holch.

4 recordsLinked to original sources

PubMed2004

Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.

Animals↗

PubMed2000

[Parathyroid gland carcinoma with postoperative encephalopathy].

We present a 78-year-old patient who suffered from symptomatic transitory psychotic syndrome after laparotomy. Persisting somnolence appeared with cardiopulmonary decompensation and gastrointestinal atony. Due to prolonged hypercalcemia primary hyperparathyreoidism was diagnosed. Resection of a large carcinoma of the parathyroids led to continuous clinical improvement.

Adenoma↗

PubMed1984

Volume, staging and grading of gastro-intestinal carcinoma--a population-based study.

All cases of the Regional Cancer Registry, North Baden who developed a gastro-intestinal cancer during the period 1975-1980 were re-examined according to the following parameters: tumor volume, pT stage, pN stage, grading. In the period considered, 8424 cases out of 14,061 cases with histologically proven gastrointestinal cancer could be grouped according to the pT stage. Most of the cases were operated at the pT2 or pT3 stage. Remarkable differences in the different tumor localizations were obtained. Stomach carcinoma had the highest percentage of the pT4 stage (36.2%), rectum carcinoma the lowest (7%). In all primaries a close coherence of tumor volume and pT stage was noted. Carcinoma at the pT1 stage measured 20 cm3 on average, those at the pT4 stage 170 cm3. No coherence of staging and age of the patients could be obtained. Younger patients showed a higher percentage of undifferentiated carcinoma than older patients. Survival data could not be obtained due to the data protection law.

Adult↗

PubMed1984

[Population based data in North Baden on malignant tumors of the gastrointestinal tract].

Population-based data of malignomas of the gastro-intestinal tract were evaluated from the regional cancer registry North-Baden for the period of 1971-1980. The age standardized incidence of oesophagus carcinomas shows a steady level of 4.5/100,000 (males) and 0.5/100,000 (females); the age standardized incidence of stomach carcinomas increased from 1971 to 1974, then shows a decline for both males and females, where the colon carcinomas show an increase of 80% for the same time period, also the cancer of the small intestines and of the rectum, increased slightly. Compared to data of other cancer registries the world standardized incidence of rectum carcinomas is of the same level as the data from the cancer registry of Bas-Rhin and is with an incidence of 25.8/100,000 males; 16.2/100,000 females above the incidence of all other cancer registries. The post-operative TNM-stage differs for the different primary topographies. Especially patients with colon carcinomas were operated when the carcinoma was in an advanced stage, patients with rectum carcinomas were operated at a less advanced stage. Male patients with an oesophagus carcinoma showed in a significant percentage an advanced smoking and alcohol consumption, compared to patients suffering from stomach, colon or rectum carcinomas. The specialized organisation of the cancer registry shows a high efficiency due to the requirements of the public health system, and is very useful in the evaluation of descriptive and analytic population-based cancer data.

Adult↗