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PubMed · 15243972

Physiology: does gut hormone PYY3-36 decrease food intake in rodents?

M Tschöp·T R Castañeda·H G Joost·C Thöne-Reineke·S Ortmann·S Klaus·M M Hagan·P C Chandler·K D Oswald·S C Benoit·R J Seeley·K P Kinzig·T H Moran·A G Beck-sickinger·N Koglin·R J Rodgers·J E Blundell·Y Ishii·A H Beattie·P Holch·D B Allison·K Raun·K Madsen·B S Wulff·C E Stidsen·M Birringer·O J Kreuzer·M Schindler·K Arndt·K Rudolf·M Mark·X Y Deng·D C Whitcomb·H Halem·J Taylor·J Dong·R Datta·M Culler·S Craney·D Flora·D Smiley·M L Heiman·D C Withcomb
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Abstract

Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-weight gain in rodents, a discovery that has been heralded as potentially offering a new therapy for obesity. However, we have been unable to replicate their results. Although the reasons for this discrepancy remain undetermined, an effective anti-obesity drug ultimately must produce its effects across a range of situations. The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3-36.

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AnimalsAnimals, Inbred StrainsAppetiteAppetite DepressantsAppetite RegulationBehavior, AnimalBody WeightEnvironmentFeeding BehaviorHumansMeta-Analysis as TopicMiceObesityPeptide FragmentsPeptide YYRatsReproducibility of ResultsStress, PhysiologicalCommentJournal Article

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M Tschöp, T R Castañeda, H G Joost, C Thöne-Reineke, S Ortmann, S Klaus, M M Hagan, P C Chandler, K D Oswald, S C Benoit, R J Seeley, K P Kinzig, T H Moran, A G Beck-sickinger, N Koglin, R J Rodgers, J E Blundell, Y Ishii, A H Beattie, P Holch, D B Allison, K Raun, K Madsen, B S Wulff, C E Stidsen, M Birringer, O J Kreuzer, M Schindler, K Arndt, K Rudolf, M Mark, X Y Deng, D C Whitcomb, H Halem, J Taylor, J Dong, R Datta, M Culler, S Craney, D Flora, D Smiley, M L Heiman, D C Withcomb. 2004-07-08. Physiology: does gut hormone PYY3-36 decrease food intake in rodents?. https://doi.org/10.1038/nature02665

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