PubMed Health⌕ Search

Biomedical subjects

P Osswald

Publications and source records attributed to P Osswald.

28 records · Page 2Linked to original sources

[Differential diagnosis and follow-up studies in sucklings and infants with continuous cholestasis (author's transl)].

Among liver biopsies from 91 children between the age of 36 hrs and 2 years, puncture or excision was done for clarification in 64 cases. The morphological differential diagnosis between the various forms of intra- and extrahepatic bile duct dysplasias and their define characteristics related to hepatitis is presented. Morphological changes have given the basis for our grouping of diseases with cholestasis in early childhood. Our conclusions were summarized and proved in some schematic tables. Particular emphasis was given to comparative time observations for bioptic examined children over longer periods. Hereby results prognostic knowledge which should stimulate our therapeutic handling.

Bile Ducts↗

Serum enzyme, bilirubin, uric acid, and cholesterol concentration changes during 7 days of total parenteral nutrition.

Lactic dehydrogenase, glutamic oxalacetic transaminase, and alkaline phosphatase remained within normal limits during 7 days of total parenteral nutrition. Five patients showed a rise of total bilirubin up to 1.1 mg/100 ml on the fifth postoperative day, with no change in serum enzymes. Uric acid concentration fell continuously up to the third postoperative day (but within normal limits) and remained decreased until the end of infusion. During the preoperative nutrition period and after surgical intervention, cholesterol concentration showed a steep fall. Very low cholesterol concentrations can cause an alteration of erythrocyte membrane synthesis and should, therefore, be avoided.

Alkaline Phosphatase↗