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Biomedical subjects

P R Davis

Publications and source records attributed to P R Davis.

At least 19 recordsLinked to original sources
PubMed2005

Accidental hypothermia.

Hypothermia is a multi-system disorder that significantly increases morbidity and mortality in the injured patient. It is an environmental hazard that can kill in its own right. The most difficult differentiation and management decisions are likely to be with victims in Stage II or Stage III hypothermia. Following successful rescue in these cases, arresting any further cooling of the core temperature, instituting rewarming strategies and careful patient handling will be the key factors in reducing morbidity and mortality.

Body Temperature↗
PubMed2000

Pseudallescheria boydii infection of the nasal cavity of a horse.

An 18-year-old 454-kg (1,000-lb) American Quarter Horse gelding was evaluated because of chronic intermittent malodorous right-sided nasal discharge. Endoscopy revealed a mycotic plaque in the nasal cavity adjacent to the nasomaxillary opening of the right caudal maxillary sinus. The nasomaxillary opening appeared to be larger than normal. Fungal culture of specimens of the mycotic plaque yielded Pseudallescheria boydii. The horse was treated with 2% miconazole intranasally, sodium iodide i.v., and potassium iodide p.o. Thirty and 60 days after treatment was initiated, the nasal cavity was found to be free of infection.

Animals↗
PubMed1980

Pattern of accident distribution in the telecommunications industry.

Examination of the accident records from the telecommunication industry covering some 100 000 engineers over a 12-month period showed that 25% of accidents resulting in more than three days' sick leave gave rise to back injuries. Handling accidents and falls accounted for 65% of three-day-plus accidents; handling accidents alone gave rise to 65% of back injuries. The absolute numbers of accidents have been compared with the total population of engineers to estimate the effects of age or occupation on levels of hazard; certain occupations constituting 33% of the engineers' population suffered 70% of all three-day-plus accidents. Accidents occurred most frequently in the group aged from 31 to 48 years. Other significant factors affecting the occurrence of accidents were time of year and duty experience of the workers.

Accidents, Occupational↗
PubMed1980

Plasma and sputum erythromycin concentrations in chronic bronchitis.

Plasma and sputum concentrations of erythromycin were measured in 10 patients with chronic bronchitis during an eight-day course of a new formulation of erythromycin stearate. The plasma erythromycin levels compared favourably with the minimal inhibitory concentrations for common respiratory pathogens and indicated adequate gastrointestinal absorption when the drug was taken immediately before food. Sputum erythromycin levels were variable and in some patients low or undetectable. Measurable sputum erythromycin levels were approximately 10% of plasma levels with no evidence of accumulation and were of similar order of magnitude to the minimal inhibitory concentrations for common respiratory pathogens except Haemophilus influenzae. There was no correlation between sputum and plasma erythromycin levels. There was a trend for higher erythromycin levels in sputum containing increasing amounts of pus and also when plasma levels increased.

Aged↗
PubMed1979

Bone-marrow pressure and bone strength.

The pattern of bone-marrow pressure changes differed with the mode of stress application. Intra-medullary pressure remained steady during most of the slow loading. During rapid dynamic loading, however, a slight rise in intra-medullary pressure was observed. Contraction of the femoral muscles also resulted in a greater bone-marrow pressure increase. A correlation of 0.98 (P less than 0.001) between stimulus strength and intra-medullary pressure was obtained. The rise in intra-medullary pressure with femoral muscle contraction is suggested to have a possible role under extreme stresses in living conditions.

Animals↗
PubMed1977

Influence of dosage and dietary sodium on the first-dose effects of prazosin.

The effects of the first dose of prazosin were assessed in hypertensive patients on different sodium intakes. Patients received 250, 100, or 30 mmol sodium per 24 hours for a week before taking 2 mg or 0-5 mg prazosin. The acute effects of prazosin on blood pressure and pulse rate were milder with a high sodium intake. On the 100-mmol intake symptomatic postural hypotension occurred in five out of seven patients given 2 mg prazosin and in two out of four given a 0-5-mg dose, whereas those taking 2 mg or 0-5 mg and a 250-mmol sodium intake experienced no postural symptoms. These findings indicate that particular care should be taken in starting prazosin treatment in sodium-depleted patients.

Adult↗