Biomedical subjects
Publications and source records attributed to P R Marwadi.
Reserpine was shown to generate a liquid membrane. Transport of adrenaline, noradrenaline, dopamine, 5-hydroxytryptamine, glutamic acid, and gamma-aminobutyric acid in the presence of the reserpine liquid membrane was studied. The data indicate that the phenomenon of liquid membrane formation is likely to play a role in the mechanism of reserpine action.
Chlorpromazine has been shown, in the present study, to generate a liquid membrane at an interface in accordance with Kesting's hypothesis [5]. The specific orientation of chlorpromazine molecules in a liquid membrane with hydrophobic ends facing the permeable substances has been found to reduce the permeability of catecholamines and neurotransmitter amino acids. This observation is discussed in the light of the orientation of receptor proteins in general. The data on transport of catecholamines and neurotransmitter amino acids are discussed in the context of the mechanism of action of chlorpromazine.
Haloperidol, a surface-active neuroleptic drug, was shown to generate a liquid membrane on a supporting membrane. Transport of adrenalin, noradrenalin, dopamine, serotonin, histamine, glutamic acid, gamma-aminobutyric acid, and sodium, potassium, and calcium ions through the haloperidol liquid membrane was studied. The data indicate that the phenomenon of a liquid membrane plays a significant role in the mechanism of action of haloperidol.