PubMed Health⌕ Search

Biomedical subjects

P Tóth

Publications and source records attributed to P Tóth.

At least 73 records · Page 4Linked to original sources

Serum lipid and lipoprotein-cholesterol values in cord blood and on the sixth postnatal day in newborns of varying maturity.

Triglyceride, total cholesterol, phospholipid, HDL-cholesterol, VLDL-cholesterol and LDL-cholesterol concentrations were studied in 22 eutrophic, 16 true premature and 22 small-for-gestational age neonates in cord blood and on the 6th postnatal day. According to the findings the lipid-lipoprotein metabolism was influenced primarily by gestational age. Parallel with increasing gestational age, phospholipid and triglyceride concentrations rose whereas cholesterol values decreased. Postnatal changes of lipid-lipoprotein metabolism developed more slowly in premature than in mature newborns. The effects of intrauterine malnutrition manifested themselves mainly in differences of the triglyceride and phospholipid levels.

Birth Weight↗

Morphology and location of tectal projection neurons in frogs: a study with HRP and cobalt-filling.

Tectal projection neurons were labeled by retrograde transport of horseradish peroxidase (HRP) or cobaltic-lysine. The tracer substances were delivered iontophoretically or by pressure injection or diffusion into various regions of the brain or spinal cord. Histochemical procedures allowed identification of labeled cells projecting to the injected regions. Many neurons were filled with cobaltic-lysine, resulting in a Golgi-like staining. After cobalt injections in the diencephalon most of the labeled cells, identified as small piriform neurons, were located in layer 8 of the tectum. Two types of small piriform neurons were distinguished. Type 1 neurons have flat dendritic arborizations confined to lamina D, while the dendrites of type 2 cells may span all of the superficial tectal strata. In smaller numbers large piriform, pyramidal, and ganglionic cells of the periventricular tectal layers were labeled after diencephalic injections. Rhombencephalic cobalt and HRP injections labeled cells whose axons form the tectobulbospinal tract. The neurons most frequently labeled were large ganglionic cells. Ipsilaterally, the majority of their somata were located in layer 7, and their dendrites arborized mainly in lamina F. Contralaterally, labeled ganglionic cell somata occupied the top of layer 6, and most of their dendritic end-branches entered lamina B. The possible functional significance of this anatomical arrangement is discussed. After tectal cobalt injections the topography of the tectoisthmic projection and the terminals of tectal efferent fibers in the diencephalon and brainstem were observed. It is concluded that the organization of frog tectofugal pathways is very similar to that of mammals.

Animals↗

Gallstone, causing bleeding and pyloric stenosis syndrome, diagnosed by urgent gastroscopy.

By means of urgent gastroscopy the authors, right before surgery, recognized a pyloric stenosis syndrome and a gallstone that had caused massive melena in a female patient of 73. Cholecystectomy and a Billroth II gastric resection were performed. Following surgery, a transitory duodenal fistula developed. After a month of clinical treatment the patient was sent home cured. This case draws attention to the importance of removing a gallbladder filled with stones as soon as possible in order to prevent complications, as well as to the necessity for gastroscopy in cases of unexplained abdominal complaints.

Aged↗

Optokinetic horizontal head nystagmus in the frog after regeneration of transected retinal fibres.

The recovery of optokinetic responses during regeneration of transected retinal fibres was studied. Regenerated optic fibres were demonstrated by the cobaltfilling technique. After transection of the chiasma in the midline in most of the cases regenerating retinal fibres did not cross, but terminated in ipsilateral visual centres. Aberrant fibres were found in the telencephalon, the periventricular region of the diencephalon, anterior-, posterior- and ventral tegmental commissures and in the isthmic nucleus. In one group of animals optokinetic responses did not return after regeneration of retinal fibres. Re-innervation was either symmetrical on both sides from one eye, or terminal fibres were disorganized. In the second group of animals normal optokinetic nystagmus (OKN) returned. In these cases the fibres were symmetrically distributed on both sides or, alternatively, the crossed fibres outnumbered the ipsilateral ones. The third group of animals showed reversed OKN, spontaneous turning of the head, circling or head nystagmus. Here the majority of regenerated fibres termined ipsilaterally. When the OKN returned, the retinal projection was always restored in the pretectal region. Contrary to our earlier work, we concluded that the basal optic nucleus is not essential for horizontal optokinetic head nystagmus because in a few animals, retinal fibres did not invated this nucleus, and in spite of this the OKN could be evoked. We think now that the most important structure (as an input channel) for horizontal OKN of frogs is the pretectal region.

Animals↗

Re-investigation of the role of the accessory optic system and pretectum in the horizontal optokinetic head nystagmus of the frog. Lesion experiments.

The effects of various lesions in the accessory optic system and pretectal area were studied on the horizontal optokinetic head nystagmus (OKN) in the frog Rana esculenta. For histological control the cobalt-filling technique and haematoxylineosin staining were used. Isolated complete transection of the basal optic root caused only a slight reduction in the frequency of the OKN. Transection of the marginal optic tract on one side reduced the frequency as if one eye had been removed. Electrolytic destruction of the basal optic nucleus on one side did not influence the optokinetic responses significantly. In monocular animals, however, an obvious reduction occurred in the frequency of the OKN when the basal optic nucleus corresponding to the seeing eye had been destroyed. If the lesion involved the brain tissue surrounding the basal optic nucleus, nystagmus could not be evoked. Complete destruction of the lateral pretectal neuropil, which receives retinal afferents, strongly reduced the frequency or abolished the OKN. We conclude that the pretectal region is the most important structure at the input side in the initiation of this visuomotor response. The basal optic nucleus together with the neighbouring tegmental area may also play some role in the regulation of the OKN.

Animals↗

Maternal regulation of fetal growth.

The birth weight of the mothers, sibs, maternal aunts and their children were compared with those of 400 full-term, appropriate-for-gestational age, 181 true premature, 200 small-for-gestational age, and 261 correlation was found between the weight of the newborns and their mothers and maternal relatives in each case. The findings support the Ounsted theory that the rate of fetal growth is influenced by a familial component with maternal transmission. This regulation does not operate in true prematurity where the effect of environmental and pathological factors seems to prevail over the familial and genetic features.

Birth Weight↗