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Biomedical subjects

Paulo Lisboa

Publications and source records attributed to Paulo Lisboa.

3 recordsLinked to original sources

Gait quality assessment using self-organising artificial neural networks.

In this study, the challenge to maximise the potential of gait analysis by employing advanced methods was addressed by using self-organising neural networks to quantify the deviation of patients' gait from normal. Data including three-dimensional joint angles, moments and powers of the two lower limbs and the pelvis were used to train Kohonen artificial neural networks to learn an abstract definition of normal gait. Subsequently, data from patients with gait problems were presented to the network which quantified the quality of gait in the form of a single curve by calculating the quantisation error during the gait cycle. A sensitivity analysis involving the manipulation of gait variables' weighting was able to highlight specific causes of the deviation including the anatomical location and the timing of wrong gait patterns. Use of the quantisation error can be regarded as an extension of previously described gait indices because it measures the goodness of gait and additionally provides information related to the causes underlying gait deviations.

Biomechanical Phenomena↗

Quantitative risk modelling for new pharmaceutical compounds.

The process of discovering and developing new drugs is long, costly and risk-laden. Faced with a wealth of newly discovered compounds, industrial scientists need to target resources carefully to discern the key attributes of a drug candidate and to make informed decisions. Here, we describe a quantitative approach to modelling the risk associated with drug development as a tool for scenario analysis concerning the probability of success of a compound as a potential pharmaceutical agent. We bring together the three strands of manufacture, clinical effectiveness and financial returns. This approach involves the application of a Bayesian Network. A simulation model is demonstrated with an implementation in MS Excel using the modelling engine Crystal Ball.

Algorithms↗

Visualisation of gait data with Kohonen self-organising neural maps.

Self-organising artificial neural networks were used to reduce the complexity of joint kinematic and kinetic data, which form part of a typical instrumented gait assessment. Three-dimensional joint angles, moments and powers during the gait cycle were projected from the multi-dimensional data space onto a topological neural map, which thereby identified gait stem-patterns. Patients were positioned on the map in relation to each other and this enabled them to be compared from their gait patterns. The visualisation of large amounts of complex data in a two-dimensional map labelled with gait patterns is a step towards more objective analysis protocols which may enhance decision making.

Databases, Factual↗