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Biomedical subjects

Ph Demaerel

Publications and source records attributed to Ph Demaerel.

9 recordsLinked to original sources

Hypertensive brain stem encephalopathy in a patient with chronic renal failure.

Hypertensive brain stem encephalopathy is a rare disorder that can be seen in severe hypertensive encephalopathy. Patients with chronic renal failure are more prone to develop this disorder because a mild elevation of the blood pressure can already induce brain changes. It is important to diagnose this entity as soon as possible because the symptoms and brain stem lesions are reversible following treatment and because it is important to exclude brain stem ischemia in the diagnostic work-up. Brain MRI and particularly diffusion weighted images are crucial for this purpose.

Aged↗

Intra-axial brain tumours.

The radiological diagnosis and differential diagnosis of intra-axial tumours no longer relies on CT scan and routine MR sequences alone. Standard multiplanar imaging has to be combined with fMRI to allow the exact anatomic location of the lesion and precise determination of the extension of the tumour. Perfusion and diffusion MR is becoming more and more important in the differential diagnosis of cerebral mass lesions and in the grading and typing of gliomas. More sophisticated techniques such as diffusion tensor imaging and spectroscopy will further enhance the value of the radiological studies.

Adult↗

Diffusion-weighted MR imaging findings in a patient with herpes simplex encephalitis.

INTRODUCTION: Herpes simplex meningoencephalitis is one of the most common viral central nervous system infection in adults. Early diagnosis is essential for treatment. CASE REPORT: We present a case of a 68-year-old female patient with herpes simplex infection. On admission, she was in severe clinical condition. Diffusion-weighted (DW) magnetic resonance imaging detected brain involvement better than conventional sequences. After acyclovir therapy, the patient fully recovered. CONCLUSION: DW magnetic resonance imaging is expected to provide a more sensitive imaging in herpes simplex patients than conventional sequences.

Aged↗

Desmoplastic infantile ganglioglioma: a potentially malignant tumor?

Desmoplastic infantile ganglioglioma is a rare intracranial tumor of early childhood with a usually excellent prognosis despite malignant features both radiologically and histologically. We present the case of a desmoplastic infantile ganglioglioma with histologically highly anaplastic features and both intracerebral and pial metastases. After partial resection the tumor was rapidly progressive and new metastases appeared. A combination of vincristine and carboplatinum was used according to the Low Grade Glioma Protocol of the International Society of Pediatric Oncology, with a temporary good response. When histologically characterized by highly anaplastic features, it seems the biologic behavior of this tumor remains uncertain. The aggressive behavior and the responsiveness to chemotherapy in this case may challenge the belief in the benign nature of these rare tumors.

Antineoplastic Combined Chemotherapy Protocols↗

From X-rays to radiofrequency waves or the changing practice of diagnostic neuroradiology: imaging, health care and economical aspects.

Over the past 25 years, radiology has become an increasingly important diagnostic technique in medicine. The majority of radiological techniques still use x-rays, despite the availability of other techniques that do not use ionising radiation. The diagnostic work-up of patients with neurological disorders underwent significant changes in the past 20 years parallel with the advances in medical technology. In neuroradiology, the imaging of the central nervous system, magnetic resonance (MR) imaging has challenged the x-ray procedures such as computed tomography (CT), myelography and angiography. MR imaging uses radiofrequency waves that do not have noxious biological effects. It is generally accepted that MR imaging yields superior image quality compared with CT. Despite the advantages of MR imaging, CT remains an important investigation and has not been replaced by MR. In this memoir the state of the art imaging procedures in diagnostic neuroradiology are reviewed, with their advantages and disadvantages. The failed substitution of CT by MR imaging seems to be mainly due to the limited availability of MR installations and the still long examination times compared with CT. The impact of the changing practice of neuroradiology on health care and the economical aspects are extremely important knowing that financial resources are limited. MR leads to a decrease in invasive diagnostic and therapeutic procedures and the real cost of MR seems to be less than expected. Health care technology assessment and evidence based medicine are less well known in the radiological community, but will become increasingly important in the years to come.

Central Nervous System Diseases↗

An unusual case of hearing loss and cerebellar pathology.

This paper describes an unusual case of neurofibromatosis type I unidentified clinically and diagnosed with MRI. Both the enhancement features and the localization in the cerebellum and corpus callosum are atypical.

Cerebellum↗

Sequences and techniques in spinal MR imaging.

The optimal protocol in spinal MR imaging is not evident. Sagittal T2 weighted FSE, sagittal T1 weighted SE and axial T2 weighted FSE sequences are widely accepted for imaging patients with sciatica and/or lumbar pain. Because of the limited amount of CSF compared to the lumbar spine, the choice of sequences is much more complex in the study of the cervical spine. Sagittal T2 FSE, sagittal T1 SE and axial 2D GE images are suggested in routine cervical spine imaging. To assess the bone marrow, a STIR sequence can be added to this protocol on both lumbar and cervical spine examinations. The 2D GE produces an acceptable image quality to differentiate between the disc and bony protrusions. The use of FLAIR for imaging spinal cord lesions remains controversial in the literature.

Cervical Vertebrae↗

[Radiology versus medical imaging].

In an increasing number of hospitals in Belgium, the radiologists are changing the names from their department from "radiology" to "medical imaging". The reasons behind this change remain unclear and it is certainly not a good move in a time where turf battles will increase.

Attitude of Health Personnel↗