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Biomedical subjects

Q Q Wu

Publications and source records attributed to Q Q Wu.

5 recordsLinked to original sources
PubMed1992

[X-ray diffraction studies on tolbutamide solid dispersion].

D860 (tolbutamide) solid dispersions prepared with urea, polyvinyl pyrrolidone (PVP), and polyethylene glycal (PEG) 6000 as carriers were studied by X-ray diffraction, relating to their dissolution rates. D860 in D860-PVP dispersion was shown to be in an amorphous state and to have greater dissolution rate. D860-urea and D860-PEG melts were found to be partly in miscible solid solution state and partly in microcrystal state and possess higher activity and greater dissolution rate. D860-PEG coprecipitate was a physical mixture and its dissolution rate is slower than its melt. No variation in the crystal structure of the D860 dispersions was observed during the ageing test.

Drug Carriers↗
PubMed1990

[Preliminary report of short-course tuberculosis of the spine].

This study consisted of 149 newly diagnosed cases of tuberculosis of the spine; these were alloeated into the following two regimens: 4SHER/5HER and 4SHER/5H3E3R3. 145 cases have completed their chemotherapy. In patients (2.7%) the allocated regimens was modified because of adverse reactions. All of the patients except 9 cases, operative debridment of the spinal focus was performed within 1-3 months of the start of chemotherapy. Some of the results from this study were encouraging: (1) the therapeutic response was favourable in both regimens, and adverse reactions, mainly hepatic toxicity, were rather low, (2) after a four-month initial intensive phase, both intermittent administration for 5 months or daily treatment for 5 month in the continuation phase were of the same high efficacy at the end of treatments as well as during 4-44 months follow-up.

Adolescent↗