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PubMed · 1414371

[X-ray diffraction studies on tolbutamide solid dispersion].

X Ma·S K Rong·Q Q Wu·G X Zhou
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Abstract

D860 (tolbutamide) solid dispersions prepared with urea, polyvinyl pyrrolidone (PVP), and polyethylene glycal (PEG) 6000 as carriers were studied by X-ray diffraction, relating to their dissolution rates. D860 in D860-PVP dispersion was shown to be in an amorphous state and to have greater dissolution rate. D860-urea and D860-PEG melts were found to be partly in miscible solid solution state and partly in microcrystal state and possess higher activity and greater dissolution rate. D860-PEG coprecipitate was a physical mixture and its dissolution rate is slower than its melt. No variation in the crystal structure of the D860 dispersions was observed during the ageing test.

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Drug CarriersPolyethylene GlycolsPovidoneTolbutamideUreaX-Ray DiffractionJournal Article

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X Ma, S K Rong, Q Q Wu, G X Zhou. 1992. [X-ray diffraction studies on tolbutamide solid dispersion].. https://pubmed.ncbi.nlm.nih.gov/1414371/

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