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Biomedical subjects

R A Cawson

Publications and source records attributed to R A Cawson.

At least 37 records · Page 2Linked to original sources
PubMed1986

Warthin's tumor (cystadenolymphoma) of salivary glands. A clinicopathologic investigation of 278 cases.

This article reviews the detailed clinical and pathologic features of 278 cases of Warthin's tumor (cystadenolymphoma) from the files of the British Salivary Gland Tumor Panel. The tumor was found exclusively in the parotid gland, where it accounted for 14% of the total primary epithelial parotid tumors. The male predominance (1.6:1) was lower than in many earlier reports, and this observation is discussed. Some histopathologic features of both epithelium and stroma were semiquantified, and the presence of ciliated epithelium in a few tumors was confirmed. The Warthin's tumors were subclassified according to the scheme proposed by Seifert and colleagues. No examples of metaplastic Warthin's tumor were seen, but a few tumors were extensively necrotic and probably infarcted. The age distribution of patients with stroma-poor Warthin's tumor supported the concept that this variant develops by progressive adenomatous growth of typical Warthin's tumor. The histogenesis of Warthin's tumor is discussed briefly.

Adenolymphoma↗
PubMed1986

Benign lymphoepithelial lesion: a less than benign disease.

The precise clinical correlate of the benign lymphoepithelial lesion is unclear. Thirty-six cases of benign lymphoepithelial lesions (BLL), reported to the British Salivary Gland Tumour Panel between 1971 and 1984, have been reviewed. Eighty per cent arose in the parotid gland and 20% were bilateral; 83% were in females and the mean age at presentation was 55.26 years. Only 50% presented with, or developed, symptoms of sicca complex, Sjogren's syndrome or related autoimmune disease. Two cases of BLL had, or went on to develop, extra salivary lymphomas and 5 cases of BLL had lymphomatous change in the initial biopsy. A further case had carcinoma within the benign lymphoepithelial lesion. None of those who developed lymphoma had sicca or Sjogren's syndrome but 3 of them had rheumatoid arthritis. The incidence of lymphomas (salivary or extra-salivary) in this series is very much higher than that reported in Sjogren's patients and amounted to 20% overall.

Adult↗
PubMed1985

Salivary gland tumours. A review of 2410 cases with particular reference to histological types, site, age and sex distribution.

To date the British Salivary Gland Tumour Panel has accumulated 2569 salivary gland tumours. Of these, 2410 were primary epithelial salivary gland tumours and these formed the basis of the present study. The diagnosis of individual tumours was based on the World Health Organisation classification. Tumours were analysed according to histological type, site, age and sex. The principal site was the parotid and the combined minor (oropharyngeal) glands formed the second largest group. Pleomorphic adenomas formed the largest group of tumours in most sites, but were particularly common in the parotid. The frequency of malignant tumours increased with age after the third decade and was maximal in the eighth decade. Malignant tumours were more common in the submandibular and the minor glands than in the parotid. In the sublingual gland six out of seven tumours were malignant.

Adenoma↗
PubMed1985

Tumours of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases.

There are 2410 primary epithelial salivary gland tumours in the files of the British Salivary Gland Tumour Panel. Of these tumours, 336 (14%) involved the minor (oropharyngeal) salivary glands, and these were studied in the present investigation. Individual tumours were diagnosed according to the WHO Classification. The percentage of malignant or potentially malignant tumours (46%) was much higher than in major glands (18%), and in some of the less common intraoral sites all the tumours were malignant. The principal sites were the palate (54%), lips (21%) and buccal mucosa (11%), and, in these sites, pleomorphic adenoma was the most common tumour. Monomorphic adenomas accounted for 6% of palatal tumours, but 30% of lip salivary gland tumours. The most common malignant tumour was the adenoid cystic carcinoma. The results are compared with several other large surveys and with tumours of major salivary glands.

Adenoma↗
PubMed1984

The prognosis of specific types of salivary gland tumors.

The relative rarity of salivary gland cancers means that there are few follow-up studies based on substantial numbers on which estimates of prognosis of the individual histologic subtypes can be based. In an attempt to overcome this problem 106 reports of follow-up studies were examined. For 52 studies a statistical method was devised to calculate 5-year and 10-year survival rates in uniform fashion. Fifty-four reports, however, had to be discarded either because of inadequacy of the data provided or because certain data essential for statistical analysis was lacking. Sufficient data was available for the estimation of survival rates for 2298 malignant salivary gland tumors of four histologic types. The overall 5-year and 10-year survival rates were found to be as follows: acinic cell carcinoma 82% and 68%, respectively; mucoepidermoid carcinoma 71% and 50%, respectively; adenoid cystic carcinoma 62% and 39%, respectively; malignant mixed tumor 56% and 31%, respectively. Since the great majority (over 70%) of salivary gland tumors are pleomorphic adenomas, and also since complete excision of these tumors presents considerable difficulties, their recurrence-free rate was also estimated and found to be 96.6% after 5 years and 93.2% after 10 years.

Adenoma↗
PubMed1984

Plasmalemmasomes and lomasomes in Candida albicans.

Candida albicans possesses plasmalemmasomes and lomasomes whose origin, structure and distribution are described. It is suggested that plasmalemmasomes become lomasomes during cell wall synthesis. The endoplasmic reticulum and lomasomes may be regarded as the functional equivalent to the Golgi apparatus in C. albicans and this view is discussed.

Candida albicans↗
PubMed1982

Ultrastructural identification of extracellular material and appressoria in Candida albicans.

Ultrastructural studies of Candida albicans in its invasive form, obtained from oral lesions of patients with acute or chronic candidosis and of organisms grown on chorio-allantoic membrane of chick embryo have demonstrated a dense exudate-like material over the fungal cell wall surface. Such material appears to be involved in the digestion of the host cell wall and cell membrane, thereby assisting the organism to invade the host cell. During this invasion the apical tips of hyphae have a bulging appearance, resembling the appressoria of some plant pathogens.

Animals↗