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Biomedical subjects

R A Feldman

Publications and source records attributed to R A Feldman.

At least 127 records · Page 7Linked to original sources
PubMed1978

The Duffy blood group and resistance to Plasmodium vivax in Honduras.

To test the hypothesis that the Duffy blood group negative genotype is a factor in resistance to Plasmodium vivax, we determined the Duffy blood group, the malaria antibodies, and the slide-demonstrated infection rates with P. vivax and P. falciparum of 420 persons living in Nueva Armenia, Honduras. In all, 247 persons were Duffy negative. Demonstrated infections with P. falciparum were almost equally distributed between Duffy-positive (5,8%) and Duffy-negative (4.9%) persons. Similarly, Duffy-positive (25.6%) and Duffy-negative (28.2%) persons had equal proportions of indirect fluorescent antibody test titers suggestive of past or present P. falciparum infection. In contrast, all 14 P. vivax infections were found in Duffy-negative persons. There was no evidence suggesting that Duffy-positive and Duffy-negative persons had different exposures to malaria. The Duffy negative genotype FyFy appears to be a factor in resistance to P. vivax.

Antibodies↗
PubMed1978

An apparent outbreak of rickettsial illness in Costa Rica, 1974.

A focal outbreak of highly fatal disease occurred in eastern Costa Rica in 1974. No rickettsial spotted fevers have previously been reported in Costa Rica. Nevertheless, the available evidence points to an unidentified rickettsial pathogen, probably of the spotted fever group, as the agent responsible for this outbreak.

Adolescent↗
PubMed1977

Disease-surveillance and decision-making after the 1976 Guatemala earthquake.

In the first 3 weeks after the 1976 earthquake in Guatemala a system for collecting, analysing, and disseminating information of medical importance was instituted in the disaster area. Data on cases of selected diseases, number of available hospital beds, and medical supplies were collected, and reported epidemics were investigated. The system functioned well despite the limited numbers of trained personnel. Collection and analysis were quick enough for data to be used immediately in decision-making. No epidemics of communicable diseases were observed in the affected area. The number of dog bites in Guatemala City increased but no cases of rabies were reported. The success of the surveillance system in Guatemala suggests that immediate use of epidemiological methods should be an integral part of disaster relief.

Animals↗
PubMed1977

Sensitive method for intraoperative roentgenograms.

A new technique using mammography film has been developed. A portable x-ray machine and mammographic film has been used to obtain excellent intraoperative radiographs of renal calculi. The kidney is exposed through a flank incision. The film is cut to a size and shape that will permit an easy fit behind the kidney. Exposed film is developed in an automatic processor. This technique has facilitated location and removal of small calculi and faintly opaque calculi. Uric acid stones have been demonstrated in vitro. It is an inexpensive technique that requires no special equipment.

Adult↗
PubMed1977

Wound infection by an indigenous Pseudomonas pseudomallei-like organism isolated from the soil: case report and epidemiologic study.

A 27-year-old farmer in the Oklahoma panhandle was pinned under his overturned tractor for 2 hr and received superficial and deep lacerations. He contracted an infection of a pelvic wound with an organism that had cultural and biochemical characteristics identical to those of Pseudomonas pseudomallei. Identical organisms were recovered from soil taken from the site of the accident. The organism isolated from the wound proved to be less virulent in guinea pigs than usual laboratory strains of P. pseudomallei; fatty acid analysis showed a distinctly different pattern from that of laboratory strains of P. pseudomallei. The infecting organism may be a variant of P. pseudomallei or a new species of Pseudomonas.

Adult↗
PubMed1977

Renal cortical blood flow distribution in obstructive nephropathy in rats.

To examine the role of intrarenal hemodynamics in in obstructive nephropathy, we determined cortical blood flow distribution (CBFD) in rats with bilateral ureteral occlusion (BUO) and unilateral ureteral occlusion (UUO) during and after release of obstruction. Prior to release of obstruction of 24 hours' duration, we found that outer cortical perfusion decreased by 20+/-5% in both BUO and UUO rats. Furthermore, one hour after release of BUO, there was rapid normalization of CBFD associated with a modest return of glomerular filtration rate (GFR), an almost complete return of renal blood flow (RBF), and a marked postobstructive diuresis. In contrast, after release of UUO, we observed that outer cortical perfusion remained decreased by 21+/-31%, both GFR and RBF remained markedly depressed, and no diuresis occurred. These data demonstrate (1) marked ischemia of the outer cortex in both BUO and UUO during obstruction, (2) a rapid return of CBFD to a normal pattern after release of BUO, but (3) persistent outer cortical ischemia following release of UUO.

Animals↗
PubMed1976

Serologic therapy of tetanus in the United States, 1965-1971.

To study the influence of tetanus antitoxins on the outcome of human tatanus, we analyzed data on 545 cases reported to the Center for Disease Control from 1965 through 1971. Patients treated with antitoxin had a significantly lower case-fatality ratio than untreated patients, and the effect of serotherapy was not modified significantly by the age or race of the subjects. Antitoxin of equine origin and human tetanus immune globulin (TIG) were equally effective. The data on the effect of different doses of TIG suggest that 500 units may be as effective as the currently recommended therapeutic dose of 3,000 to 10,000 units. The importance of possible bias introduced by unmeasured factors such as quality of supportive therapy could not be determined, but confounding by 11 recorded potentially confounding factors was minimal.

Adolescent↗
PubMed1976

Inter-agency referrals and the establishment of a community-based treatment program.

Based upon a treatment program involving the referral of more than 400 "antisocial" children to a community agency, common problems associated with inter-agency referral processes are discussed. The efficacy of selected inter-agency referral processes (computation, bargaining, judgment, and inspiration) are examined. Causes of misreferrals also are discussed. These include those generated separately by the host agency and by the donor agency and those additionally generated by their mutual interaction. Suggested means for preventing dysfunctions are presented.

Behavior Therapy↗
PubMed1975

Human disease caused by Brucella canis. A clinical and epidemiologic study of two cases.

Nonlaboratory-associated human illness caused by Brucella canis occurred in two persons. Fever, chills, malaise, and weight loss were prominent symptoms in both patients. Epidemiologic investigation identified a household dog as the likely source of one patient's infection, and serologic studies and blood cultures on neighborhood dogs showed that approximately 30% were positive for B canis. Persons exposed to infected dogs appeared to have a low risk of disease. Although routine Brucella agglutinin tests do not detect antibodies to B canis, available methods for diagnosis include a specific B canis serologic test and culture techniques.

Adolescent↗
PubMed1975

The comparison of antisocial and prosocial children on multicriterion measures at summer camp.

Eighty-four prosocial children and 14 children defined as antisocial according to various diagnostic measures utilized by the professional therapeutic community were compared as to incidences of prosocial, nonsocial, and antisocial behaviors exhibited at a summer camp. Additionally, the children and their group counselors completed various inventories posited to measure antisocial behavior. A time-sampling procedure used to secure behavioral measurements on the children each day, when possible, during 60-minute intervals for a 5-week period, revealed no significant differences on prosocial,nonsocial, and antisocial behavior. Self inventories provided data contradictory to the behavioral data. The results of the study are discussed in terms of the difficulties involved in operationalizing the concept of antisocial behavior and the possibility that the antisocial children may have been labeled.

Adolescent↗
PubMed1975

Antisocial children in a summer camp environment: a time-sampling study.

A discussion is set forth regarding the possibly dysfunctional consequences of grouping antisocial children in homogeneous contexts for treatment. It is posited that antisocial children can profit from being placed for treatment in community based settings (for example, community centers, YMCAs, and neighborhood settlement houses) in which most of the other children are considered prosocial. In the present study 5 antisocial boys were placed in a residential summer camp consisting of 81 boys and 75 girls. Comparisons are made among the frequencies of prosocial, nonsocial, and antisocial behavior observed for the antisocial children placed in four groups, prosocial children in these groups, and the prosocial children in four other groups. These comparisons yield no significant differences among the antisocial and prosocial children's behavior. Findings are discussed in terms of their relevance for the helping professions.

Camping↗
PubMed1975

Patterned response of lamina V cells: cutaneous and dorsal funicular stimulation.

Single unit activity was recorded in spinal lamina V (LV) in unansthetized cats. Poststimulus-time histogram (PSTH) analysis of responses to intracutaneous stimulation demonstrated similar firing patterns for all cells. In addition to a direct relationship between stimulus intensity and the duration of cellular response, modulation of firing frequency and distinct delayed PSTH peaks in 77 percent of the units were observed. The pattern of delayed peaks was associated with the same high intensity intracutaneous stimulation reported as painful when applied to human observers. A background of dorsal funicular stimulation selectively inhibited the delayed response of LV cells to high intensity stimulation. Thus, LV cells, by their duration of firing, trasmit information related to stimulus intensity, and by their patterned responses, have the potential to relay other information, possibly related to their nociceptive role. As delayed LV activity is associated with a high proportion of small fibers in the afferent input, presynaptic inhibition of A-delta and C fibers might account for the selective inhibition associated with dorsal funicular stimulation.

Action Potentials↗