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Biomedical subjects

R Achari

Publications and source records attributed to R Achari.

At least 37 records · Page 2Linked to original sources
PubMed1985

Pharmacokinetics of flestolol in man: preliminary data.

The steady state pharmacokinetics of flestolol, a short acting beta-adrenoceptor blocking agent, were studied in six healthy subjects following intravenous infusion of six different doses; 18, 24, 35, 50, 75 and 100 micrograms kg-1 min-1, for 60 min. Steady state blood levels increased linearly with dose for all six subjects. The overall mean half-life was 6.5 min. The total body clearance averaged 208 ml min-1 kg-1 indicating significant extrahepatic metabolism of the drug. There were no significant changes in the half-lives or the total body clearances after the six doses, suggesting that the kinetics of flestolol are linear over the dose range studied.

Adrenergic beta-Antagonists↗
PubMed1984

Analysis of 4-methylpyrazole in plasma and urine by gas chromatography with nitrogen-selective detection.

A simple, sensitive, and specific gas chromatographic method for the quantitation of 4-methylpyrazole in plasma and urine is described. Samples containing 4-methylpyrazole, with 3-methylpyrazole as the internal standard, are extracted into ether and the concentrated ethereal extracts are chromatographed on a Carbowax 20M column using nitrogen-selective detection. Standard curves are linear and reproducible over the range of 25-1000 ng/mL for plasma and 0.5-5 micrograms/mL for urine. Recovery of 4-methylpyrazole is complete from plasma and urine, and the overall between-day coefficient of variation is within 6.0%. No interference is observed from the extractive constituents of plasma and urine. The assay method is suitable for an examination of 4-methylpyrazole disposition in animals and humans.

Animals↗
PubMed1983

HPLC analysis of creatinine in human plasma and urine.

A simple, rapid, reproducible HPLC method is described for the analysis of creatinine in human plasma and urine. Creatinine is isolated from plasma proteins prior to HPLC analysis by ultrafiltration using a micropartition system. The technique requires only 0.2 ml of plasma and the recovery of creatinine is complete. Results from the HPLC analysis are compared with those from an automated (colorimetric) analysis. The retention time of creatinine is 2.6 min.

Autoanalysis↗
PubMed1983

The influence of a cooked meat meal on creatinine plasma concentration and creatinine clearance.

1 The influence of a meal containing cooked meat (225 g) on creatinine plasma concentration, creatinine urinary excretion and creatinine clearance was determined in six healthy male subjects. 2 The meat meal produced an average 52% increase in creatinine plasma concentration within 1.5 to 3.5 h after ingestion. The 24 h area under the creatinine plasma concentration-time curve increased by about 19%. Urinary creatinine excretion during 24 h increased by an average of 13%. Creatinine clearance was not altered in response to the meal of cooked meat.

Adult↗
PubMed1977

Derivatization to stabilize some aliphatic primary hydroxylamines for g.l.c. analysis.

By appropriate choice of trimethylsilylating and trifluoroacetylating reagents and organic solvents for extraction, stable derivative of aliphatic primary hydroxylamines metabolites, N-hydroxyphentermine, N-hydroxychlorphentermine, N-hydroxymexiletene, N-hydroxyphenethylamine, N-hydroxyamphetamine, and N-hydroxy-3,4-dimethoxyamphetamine, were obtained and examined by g.l.c. analysis without decomposition and without interference from the parent drug or other metabolic products.

Amines↗
PubMed1977

Plasma concentrations and excretion of zipeprol in man under acidic urine conditions.

Plasma concentrations of zipeprol, and the urinary excretion of it and two of its basic metabolites, compound II and compound III were examined after oral administration of zipeprol hydrochloride to man. The drug was rapidly and extensively metabolized, and the amount of unchanged drug excreted in the acidic urine varied from 1-5% of the dose; the two basic metabolites accounted for 19-38% of the dose.

Adult↗