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Biomedical subjects

R Achari

Publications and source records attributed to R Achari.

40 records · Page 3Linked to original sources
PubMedDate not supplied

Buccal uptake, urinary excretion, and physicochemical properties of zipeprol and its N-dealkylated products.

Buccal uptake, partition characteristics, ionization constants, and urinary excretion were studied for zipeprol and two of its metabolites. Buccal uptake, measured in a single subject, was found to be correlated with n-heptane/water (ph 7.4) partition values of the compounds, and with proportional excretion of the unchanged drug. The importance of the shape of buccal uptake-pH curves in the prediction of absorption and excretion of these compounds is discussed.

Cheek↗
PubMedDate not supplied

The influence of vitamin C on antipyrine pharmacokinetics in elderly men.

The influence of vitamin C on the pharmacokinetics of antipyrine was investigated in eleven elderly men aged 65-74. Antipyrine (15 mg kg-1) was administered intravenously on three separate occasions over a 7-week period: (a) before dietary vitamin C restriction, (b) after approximately 5 weeks of dietary vitamin C restriction, and (c) after 2 weeks of vitamin C supplementation (500 mg orally twice daily). The mean plasma and leucocyte vitamin C levels (+/- S.D.) before vitamin C restriction were 1.26 +/- 0.31 mg dl-1 and 26.6 +/- 6.7 micrograms 10(-8) leucocytes, respectively. These values decreased and then increased significantly following vitamin C restriction and supplementation, respectively. The mean plasma half-life of antipyrine was 10.2 h and the mean plasma clearance was 2.561 h-1 1.73 m-2 before vitamin C restriction. No significant changes in the clearance, volume of distribution, or half-life of antipyrine occurred during the study, indicating that short-term alterations in vitamin C intake do not affect the pharmacokinetics of antipyrine in elderly males.

Aged↗
PubMedDate not supplied

Lansoprazole: administration of the contents of a capsule dosage formulation through a nasogastric tube.

A single-dose, open-label, randomized, crossover bioavailability study was conducted in 24 healthy adult male volunteers to assess an alternative method of administration of lansoprazole capsules. The results of 22 subjects were analyzed. Subjects received regimen A (granules from a 30-mg capsule mixed with apple juice and administered through a nasogastric tube) or regimen B (an intact 30-mg capsule) during the first study period. The regimens were reversed during the second period 1 week later. Blood samples were obtained over 12 hours and pharmacokinetic variables were determined. No statistically significant differences in mean time elapsed to peak concentration, mean peak concentration, area under the curve (AUC)0-t, and AUC0-infinity were detected between regimens by using analysis of variance. Bioavailability was assessed by the 90% confidence interval of the two one-sided tests on the natural logarithm of AUC. The 90% confidence interval for the AUCzero-infinity ratio was 0.955 to 1.140 for regimens A to B. These results indicate similar bioavailabilities between the two regimens and demonstrate that lansoprazole capsules may be administered by mixing the capsule contents with apple juice for administration through a nasogastric tube.

2-Pyridinylmethylsulfinylbenzimidazoles↗