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Biomedical subjects

R Aggarwal

Publications and source records attributed to R Aggarwal.

At least 127 records · Page 7Linked to original sources
PubMed1993

A comparison of citations in the Indian Journal of Gastroenterology with other journals.

OBJECTIVE: Comparison of citing pattern of the Indian Journal of Gastroenterology (IJG) with that of three general gastroenterology journals included in the Science Citation Index (SCI). METHODS: Citations in articles published in the IJG in the year 1988 were analyzed; data for three control journals [American Journal of Gastroenterology (AJG), Hepatogastroenterology (HGE) and Italian Journal of Gastroenterology (ItJG)] were obtained from the SCI Journal Citation Reports for the year 1988. MAIN OUTCOME MEASURES: Yearwise distribution of citations and citing half-life; aggregate of citation scores [percentage of citations from a journal ximpact factor (IF) of that journal] for five journals most frequently cited by each of the journals; and, proportion of citations from three most cited general medical journals and three most cited gastroenterology journals as ranked by IF. RESULTS: Percentage of citations for all years from 1979 to 1988 in the IJG were lower than in the three control journals, and citing half-life longer (9.0 yr vs 6.0, 6.4, 6.9 yr for the three control journals). While aggregate citation score of IJG for the five journals most frequently cited in it was lower than that of two control journals (178.7 vs 205.4, 140.7 and 201.5 for AJG, HGE and ItJG respectively), total citations in the IJG from three most cited general medical journals (8.8 vs 9.4, 6.1 and 9.2 for AJG, HGE and ItJG respectively) and from three most cited gastroenterology journals (16.3 vs 16.0, 15.0 and 14.1 for AJG, HGE and ItJG respectively) were comparable with the control journals; this was related to lower number of citations from the journals with the highest IF in both general medicine and gastroenterology. CONCLUSIONS: Citations in IJG were older than those in the three control journals and tended to be from journals with lower IF. To improve the citation pattern of the IJG, authors contributing to it need to keep up with recent literature in high quality journals and to cite more recent citations.

Abstracting and Indexing↗
PubMed1993

Evaluation of impact factor of the Indian Journal of Gastroenterology.

OBJECTIVE: a) To determine the impact factor (IF) of the Indian Journal of Gastroenterology (IJG) for the years 1987 to 1990. b) To compare the IF of the IJG with those of other gastroenterology journals. METHODS: For each year (1987 to 1990), the number of citations received in that particular year in the journals included in the Science Citation Index (SCI) phi by items published in the IJG in the previous two years was determined by manual searching of SCI. Similarly, self citations in the IJG of articles published in the IJG were determined manually from the back volumes of the journal. IF was calculated from these data. RESULTS: The IF of IJG for the years 1987, 1988, 1989 and 1990 was 0.087, 0.092, 0.098 and 0.192 respectively. The impact factor of IJG for 1990 compared quite poorly with that of other gastroenterology journals. CONCLUSIONS: The IF of IJG, though low, has shown a progressive improvement with time. Publication of better articles in the IJG should lead to improvement in its IF.

Abstracting and Indexing↗
PubMed1993

Halothane-induced fulminant hepatic failure.

Fulminant hepatic failure developed in the early post-operative period in a patient after third exposure to halothane. Exclusion of other causes of post-operative jaundice and temporal relationship of jaundice to anesthesia suggested halothane as the etiologic agent for the submassive necrosis, which was documented at postmortem liver biopsy.

Halothane↗
PubMed1992

Intestinal lymphangiectasia: evaluation by CT and scintigraphy.

Intestinal lymphangiectasia caused severe diarrhea and generalized edema in a 40-year-old man. The diagnosis was established by clinical, laboratory, and duodenal biopsy findings. The abnormalities detected on computed tomography (CT) and scintigraphy using 99mTc human serum albumin are herein described and pertinent literature is briefly reviewed.

Adult↗
PubMed1992

Novel monoclonal antibodies to cyclosporine A: characterization and epitope mapping with cyclosporine analogs and cyclophilin.

Monoclonal antibodies to cyclosporine A (Cs), a potent immunosuppressant, were generated in BALB/c mice using a novel antigen prepared by linking Cs to a protein carrier via a photoactive cross-linking reagent, 4-benzoylbenzoic acid (BBa). Twenty-two monoclonal anti-Cs antibodies were generated, using Cs-BBa-bovine serum albumin (Cs-BBa-BSA) as the immunogen. They were characterized with respect to affinity by Scatchard analysis of a radioimmunoassay (RIA), and with respect to specificity by an ELISA in which a series of singly substituted Cs derivatives were examined as inhibitors. McAb affinities ranged from 5 x 10(-8) M to 2 x 10(-10) M. Based on ELISA inhibition data with Cs analogs, and on the binding to two Cs-BSA conjugates in which opposite sides of the Cs molecule are exposed, the antibodies fell into five epitope recognition groups. Binding to Cs was also studied by ELISA in competition with cyclophilin (CyP), a Cs-binding protein whose epitope specificity has been well characterized. Competition by CyP was found to correlate with antibody specificity, not with affinity, i.e. CyP competed best with antibodies having specificities most similar to that of CyP. Epitope mapping can, therefore, be accomplished in a system in which two different species of binding proteins compete for the same antigen. This type of characterization may be useful in identifying antibodies whose combining sites mimic those of a receptor.

Amino Acid Isomerases↗
PubMed1992

Significance of antibodies to phenolic glycolipid-I in leprosy diagnosis.

A gelatin particle agglutination assay for the detection of anti PGL-I antibodies in 40 clinically diagnosed and variously classified groups of leprosy cases revealed elevated PGL-I antibody titers in 85% of cases. In contrast, the slit-skin smear examination was positive in only 30% of cases. It was further observed that, out of 28 cases with Bacteriological Index (B.I.) zero, 22 cases (78.5%) had significant levels of PGL-I antibodies. There was no case in which the slit skin smear was positive and the PGL-I antibody titer was not significant. The elevated titers of PGL-I antibody better correlated (84%) with histopathological findings than did B.I. Thus it was concluded that estimation of PGL-I antibody titer is a better supplement to clinical diagnosis than B.I. Significant levels of PGL-I antibody were seen in 85% of cases who had no earlier chemotherapy or were treated for less than 2 months. Similar findings were observed in 12 patients who were on MDT for more than 5 months but for less than 2 years. In order to determine the significance of anti PGL-I antibodies in monitoring the response of patients to chemotherapy, a longer follow up with a greater number of cases should be contemplated.

Antibodies, Bacterial↗
PubMed1992

Effect of anthelmintics on phosphatases in Ascaridia galli.

In vitro addition of the drugs tetramisole (TMS) and levamisole (LMS) caused an inhibition of the specific activities of acid phosphatase and Mg(++)-dependent adenosine triphosphatase. The inhibition was non-competitive in nature. No significant inhibition was caused by TMS in the activity of glucose-6-phosphatase, but LMS inhibited the enzyme in a non-competitive manner. The activity of alkaline phosphatase was, however, increased in the presence of both TMS and LMS.

Animals↗
PubMed1992

Colonic lipoma, masquerading as malignant tumour.

A case of symptomatic colonic lipoma, mimicking malignant tumour on colonoscopy, barium contrast studies and at laparotomy, is reported. The diagnosis was established on histopathology after left hemicolectomy.

Colonic Neoplasms↗
PubMed1992

A large waterborne viral hepatitis E epidemic in Kanpur, India.

In 1991 the largest epidemic of viral hepatitis E yet reported occurred in Kanpur (population, 2.1 million), India. The incidence of icteric hepatitis from December 1990 to April 1991 among the inhabitants of 420 randomly sampled houses in seven of the city's 50 wards was 3.76% (138 out of 3666 individuals), i.e., an estimated 79,091 persons in the city as a whole were affected. The attack rate was higher for males than females (5.3% versus 3.3%; P = 0.013) and for adults than children aged < 10 years (4.26% versus 1.29%; P = 0.0006). The incidence of hepatitis was higher in those city wards that were supplied with drinking-water consisting of a mixture of river Ganges and tubewell water than in those wards supplied only with tubewell water (5.6% versus 1.2%; P = 10(-6)). In the mixed-water areas, the incidence decreased as the drinking-water source changed from only tap to both tap and handpump, to only handpump (7.8%, 6.8%, and 4.3% respectively; P = 0.023). None of the sera collected from 41 hepatitis patients during the epidemic showed evidence of hepatitis virus A or B. There were two peaks in the epidemic (in February and April 1991). The first peak was probably caused by faecal contamination of river water, indicated by water analysis data, and the second, by inadequate chlorination of water in a reservoir. There was no evidence of secondary intrafamilial spread.

Adult↗
PubMed1992

Explosive Campylobacter jejuni diarrhea in immunoproliferative small intestinal disease.

Campylobacter jejuni is an infrequent cause of self limiting acute diarrheal disease in adults in the Indian subcontinent. We report the occurrence of a life threatening diarrhea due to C jejuni infection in a patient with immunoproliferative small intestinal disease. We postulate that immunosuppression due to malignancy, malnutrition and cancer chemotherapy was responsible for the unusually severe diarrhea.

Adult↗