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Biomedical subjects

R Aggarwal

Publications and source records attributed to R Aggarwal.

At least 163 records · Page 9Linked to original sources
PubMed1987

Exporting labor: the impact of expatriate workers on the home country.

The economic impact of emigration on the source country is analyzed through a literature review and a discussion of costs, benefits, and public policy implications. It is noted that "information collected from different sources and settings is needed for cross-validation of assessments and conclusions. Second....the cost/benefit analysis of emigration should be undertaken on a case by case basis. Third...these costs and benefits must be assessed in a long-term framework that considers the socio-economic conditions and the goals of the country....Fourth, effective governmental policies...need to recognize that emigrants generally are highly motivated people [who] are adept at overcoming legal or other obstacles in their path." (SUMMARY IN FRE AND SPA)

Behavior↗
PubMed1986

A survey of osteoporosis using the calcaneum as an index.

Two hundred radiographs of the calcaneum and 200 radiographs of the femoral neck from 100 persons were compared. A system of calcaneal grading, different from that earlier reported, was evolved which correlated significantly with the Singh Index. We found that resorption of secondary tensile and compressive trabeculae occurred before resorption of the primary trabeculae. Interruption of primary compressive trabeculae, which was previously described, is an inconstant feature. Our system using six grades is easier to correlate with the Singh Index. We found that osteoporosis increased progressively with age and was three times more common in females than males.

Adult↗
PubMed1984

Monocyte lysosomal enzyme release in response to naturally occurring circulating immune complexes.

To investigate the influence of naturally occurring immune complexes (ICs) on monocyte lysosomal enzyme release, blood monocytes have been isolated from normal human volunteers, purified, and maintained in culture for 5 days. These cells have been exposed in vitro to sera containing ICs and to the same sera depleted of ICs with 2% polyethylene glycol (PEG). IC-containing sera have been shown to result in increased lysosomal enzyme release (N-acetyl-beta-glucosaminidase (NAG) and beta-glucuronidase) sustained for up to 5 days even after brief (24-h) exposure (NAG activity at 120 h, nmol substrate hydrolysed ml-1 culture supernatant: control, 98 +/- 27; 2% PEG control, 70 +/- 10; IC serum exposure for 120 h, 305 +/- 73; IC serum exposure for 24 h, 330 +/- 95; exposure to IC-depleted sera 120 h, 158 +/- 93). Further analysis showed no relationship between the total IC concentration and enzyme release, nor was there any relationship between the complement component (C3) composition of the complexes and degree of enzyme release. These results confirm the potential importance of circulating IC on monocyte activation in man and indicate that this could result in changes in macrophage activity at the sites of inflammation.

Acetylglucosaminidase↗
PubMed1984

Influence of naturally occurring human immune complexes on monocyte movement in vitro.

The influence of naturally occurring immune complexes (IC) on monocyte motility has been investigated. Both chemokinesis and chemotaxis have been measured, using modified Boyden chambers, in response to sera containing IC and to the same sera depleted of IC with 2% polyethylene glycol. Chemokinetic activity was markedly increased in the presence of IC-containing sera, and this increased activity was largely abolished, following IC depletion. The chemotactic activity of the IC-containing sera was largely independent of the IC content, since IC depletion only resulted in a modest decrease in stimulated movement. The chemotactic response to a standard chemoattractant (zymosan-treated sera) was significantly increased with the cells in the presence of IC-containing sera, and this effect was abolished following IC depletion. There was no relationship between the total IC concentration and changes in monocyte movement. These results indicate that circulating IC may markedly alter monocyte locomotion in such a way that more cells may be attracted more rapidly to an inflammatory focus.

Antigen-Antibody Complex↗
PubMedDate not supplied

Management of traumatic shock.

Trauma is the leading cause of death in the pediatric age group. About 25,000 children die each year and one million children are injured each year in the USA. Aggressive resuscitation determines the outcome of these injured children. The initial hour following the traumatic injury is referred to as the "golden hour" during which we have an opportunity to intervene and improve the outcome. It is not only the first hour which is important but every minute in trauma resuscitation is important. The outcome of traumatic children has a direct correlation to resuscitation. In order to manage traumatic shock there are four basic principles: (a) control of active hemorrhage, (b) assessment of circulatory status, (c) rapid intravascular access, and (d) aggressive fluid resuscitation. Following the four principles of management of traumatic shock and aggressive resuscitation improves the outcome.

Child↗
PubMedDate not supplied

Lower airway disease caused by respiratory syncytial virus.

Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract disease in infants and young children. Most infections due to RSV are mild and do not require hospitalization. RSV causes both upper respiratory tract infections as well as lower respiratory tract infections. Infants with underlying disease states like bronchopulmonary dyslasia, congenital heart disease and prematurity appear more prone to develop severe infection and have a higher incidence of hospitalization. The exact pathogenesis of RSV is not well understood. The mortality associated with primary RSV infection in healthy children is estimated to be between .005% to .02%. In hospitalized children the mortality rate is estimated to be from 1% to 3%. Several treatment modalities in the form of bronchodilators, corticosteroids, ribavirin, intravenous immune gammaglobulin and antibiotics are available. Studies have failed to show the true beneficial effect of any of the above treatment modalities. Supportive care is only needed. The best treatment is the supportive care in the form of oxygen and fluids and close monitoring of the vital signs including oxygen saturation.

Bronchiolitis↗
PubMedDate not supplied

Prevalence of high--risk human papillomavirus infections in women with benign cervical cytology: a hospital based study from North India.

INTRODUCTION: Cervical cancer is the commonest cancer among Indian women. High-risk human papillomavirus (HPV) detection holds the potential to be used as a tool to identify women, at risk for subsequent development of cervical cancer. There is a pressing need for identifying prevalence of asymptomatic cervical HPV infection in the local population. OBJECTIVE: To determine the prevalence of high-risk HPV DNA in women with benign cervical cytology. MATERIALS AND METHODS: Women visiting the gynecology outpatient with varied complaints were subjected to Pap smear. Four hundred and seventy two samples were subjected to polymerase chain reaction, using consensus primers for low and high-risk HPV (types 6, 11, 16, 18, 31 and 33). The samples that were positive for HPV DNA were subsequently assessed for high-risk consensus primers, types 16, 18, 31 and 33 as well as for HPV type 16 and 18. RESULTS: One hundred and seventy four (36.8%) women tested positive for HPV DNA. Thirty nine (8.2%) of the entire cohort tested positive for high-risk HPV. Fifteen samples were positive for type 16, 22 for type 18 and two for both types 16 and 18. A statistically higher prevalence of high-risk HPV was observed in poorly educated and rural groups. No association of HPV prevalence was noted with age, parity and age at marriage. CONCLUSION: The study generates epidemiological data of prevalence of sub-clinical HPV in the women visiting a tertiary care institute as well as peripheral health centres. The data generated will be useful for laying guidelines for mass screening of HPV, treatment and prophylaxis in the local population.

Adult↗