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Biomedical subjects

R B Towbin

Publications and source records attributed to R B Towbin.

98 records · Page 6Linked to original sources

Aggressive fibromatosis of the tongue: MR demonstration.

A case of aggressive fibromatosis of the tongue is described in a 9-year-old boy. Magnetic resonance was used in the initial evaluation and revealed a well defined mass in the anterior third of the tongue which was mildly hypointense on a T1-weighted image and minimally hyperintense on a T2-weighted image. Magnetic resonance was useful in indicating the benign nature of the tumor, in defining its extent, and for follow-up after local surgical resection.

Child↗

Tuberous sclerosis: diagnostic and surgical considerations.

Twenty-six patients with tuberous sclerosis have been reviewed from the standpoints of CT diagnosis and surgical indications. It was concluded that a diagnosis can be made on the basis of subependymal calcification but not on the basis of cortical calcifications or low density lesions alone. Enhancing lesions, especially at the foramen of Munro, must be considered to be tumors and should be excised if there are symptoms of obstruction. The transcallosal approach is preferred. Asymptomatic enhancing lesions may be followed by periodic scans; if no enhancing lesions are present routine follow-up scans do not appear to be useful.

Adolescent↗

Benign extra-axial collections of infancy.

The clinical histories, physical examinations and results of head computed tomography and head ultrasound scans were reviewed in a group of 15 infants who had macrocrania, excessive extra-axial fluid and normal development. Diagnostic evaluations demonstrated mild ventriculomegaly and extra-axial fluid collections. No treatment was undertaken. All infants continued to exhibit normal development during a period of extended follow-up. In this select group of infants exhibiting these findings, treatment appears to be unnecessary and the prognosis for continued normal development is excellent.

Brain↗

Direct sagittal computed tomography of the head in childhood.

Direct sagittal computed tomography (CT) was performed on 47 children with pathology in the posterior fossa, orbit, parasellar region, face and ear. The direct sagittal projection provided additional information about the extent of disease and relationship of the pathologic process to the adjacent tissues in 43% of patients studied. Direct sagittal CT has improved spatial resolution over reformatted images. It is readily available, less costly than magnetic resonance and can provide similar useful anatomic information.

Adolescent↗

Percutaneous transnasal sphenoidotomy with sphenoid window.

Ten percutaneous transnasal sphenoidotomies were performed in nine children; and in seven, a sphenoid window was also created. All procedures were performed in the special procedures laboratory, with biplane fluoroscopic guidance used in each case. Under general anesthesia, with the child in the supine position, a 14-gauge antral trocar was placed transnasally into the sphenoid sinus. The sinus was aspirated and material was obtained for culture. A Takahashi forceps was placed via the same tract into the sphenoid sinus. The cusps were centered across the anterior cortex, and under fluoroscopic visualization, opened and rotated 360 degrees, creating a sphenoid window. All procedures were completed without complication, and no child required further surgery.

Adolescent↗

Reversal sign on CT: effect of anoxic/ischemic cerebral injury in children.

A retrospective study was performed to determine the clinical and pathologic features, etiology, and outcome of children with the reversal sign. The reversal sign, a striking CT finding, probably represents a diffuse, anoxic/ischemic cerebral injury. CT features of the reversal sign are diffusely decreased density of cerebral cortical gray and white matter with a decreased or lost gray/white matter interface, or reversal of the gray/white matter densities and relatively increased density of the thalami, brainstem, and cerebellum. Twenty children with the reversal sign were retrospectively analyzed. We divided the patients into three groups: (1) acute reversal, (2) intermediate group, and (3) chronic reversal. There were nine cases of trauma (seven of child abuse); nine hypoxia/anoxia incidents (birth asphyxia, drowning, status epilepticus); one bacterial meningitis; and one degenerative encephalitis. All acute- and intermediate-group patients had respiratory problems requiring ventilator support and intensive care. In five of seven patients who died, autopsy findings were consistent with anoxic/ischemic encephalopathy. Surviving patients have profound neurologic deficits with severe developmental delay. The CT reversal sign carries a poor prognosis and indicates irreversible brain damage.

Brain↗