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Biomedical subjects

R Böcker

Publications and source records attributed to R Böcker.

At least 37 records · Page 2Linked to original sources
PubMed1985

Quantitative assessment of the polysome profile of the livers of mice treated with tetracycline or doxycycline.

The influence of tetracycline and doxycycline (10-100 micrograms/g i.v.) on the aggregational state of ribosomes from mouse liver was tested. Both drugs caused a disaggregation of the ribosomes as evidenced by a rise of the monosomes + disomes/polysomes ratio. Tetracycline was much more potent than doxycycline, the minimum effective doses for tetracycline being 10 micrograms/g i.v. as compared to 100 micrograms/g for doxycycline. The results show that tetracycline but not doxycycline at therapeutic dose range may interfere with the protein synthesis of the liver.

Animals↗
PubMed1985

Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice.

The combined effects of ethinyl estradiol (EE) (0.5 micrograms/g s.c. once daily for 4 days) and tetracycline (TC) or doxycycline (DC) (50 micrograms/g i.v.) on liver weight and water content, serum transaminases, alkaline phosphatase, urea, triglycerides, and cholesterol as parameters of various liver functions were investigated in mice. It became apparent that depending on the parameter tested synergistic and antagonistic effects may occur, e.g., synergistic effects were observed with the serum transaminases and liver cholesterol; antagonistic effects were seen with the serum urea and serum cholesterol.

Alanine Transaminase↗
PubMed1985

Effect of toxic doses of progesterone on hepatotoxic effects of tetracycline.

The combined effects of high doses of tetracycline and progesterone on parameters indicative for liver function (serum transaminases and urea, serum and liver triglycerides and cholesterol) have been studied in mice. Apart from disturbance of cholesterol metabolism tetracycline-induced liver dysfunction was not aggravated by progesterone.

Alanine Transaminase↗
PubMed1985

Comparative effects of tetracycline and doxycycline on liver function of young adult and old mice.

The effects of tetracycline and doxycycline (25 and 100 micrograms/g i.v.) on serum GOT, GPT, urea, bilirubin, cholesterol and triglycerides and on the hepatic cholesterol and triglyceride levels have been investigated comparatively in female mice of two age groups: young adult and old. Both tetracyclines caused increases in the serum transaminases and bilirubin and in the triglyceride and cholesterol contents of the liver that were less pronounced in old than in young adult mice. The reason for the age difference may be that doxycycline and tetracycline accumulated to a greater extent in the livers of the younger age group. Only the rise of the serum urea levels after tetracycline and doxycycline was greater in old mice than in the young adults.

Aging↗
PubMed1984

Blood and organ concentrations of tetracycline and doxycycline in female mice. Comparison to males.

In mice treated with 50 micrograms/g i.v. tetracycline (TC) or doxycycline (DC), respectively, drug concentrations have been measured in serum, whole blood, liver, kidneys, lungs, heart, skeletal muscle and bones. TC reached especially high concentrations in liver, kidneys and bones. DC was initially trapped by lung tissue and accumulated in liver and kidneys. Liver concentrations were higher for TC, kidney concentrations were higher for DC. In some tissues, e.g. liver and kidneys, TC and DC reached higher concentrations in females than in males.

Animals↗
PubMed1983

[Priapism].

Explore the source record for details and available documents.

Humans↗
PubMed1983

Analysis and quantitation of a metabolite of doxycycline in mice, rats, and humans by high-performance liquid chromatography.

A metabolite of doxycycline has not previously been isolated. In this paper it is demonstrated that doxycycline is metabolized in mice, rats, and humans. By means of high-performance liquid chromatography and consecutive gel chromatography one metabolite of doxycycline was isolated from animal organs and human urine. The metabolite was tentatively identified as N-monodemethyldoxycycline by mass spectral and spectrophotometric analyses. The rate of metabolism could be enhanced by pretreatment of the animals with phenobarbital, an inducing agent of the drug-metabolizing enzymes.

Adult↗
PubMed1983

Investigation into the combined hepatotoxicity of rolitetracycline and ethinyloestradiol.

The effect of rolitetracycline (50 micrograms/g i.v.) alone or in combination with ethinylestradiol (0.1 and 1.0 micrograms/g s.c. once daily for 4 days) on liver function (BSP retention, serum GPT and SDH) and histomorphology was investigated in mice. Rolitetracycline alone increased liver weight, BSP-retention and serum GPT levels. Ethinylestradiol at the lower dose tended to enhance the BSP retention and the morphological changes of the liver produced by rolitetracycline but had no additional effect on the serum GPT and on liver weight. In contrast, hepatotoxic effects of the higher dose of ethinylestradiol were not further enhanced by rolitetracycline.

Animals↗
PubMed1983

[Tumors of the colon following ureterosigmoidostomy].

This report presents three cases of colon tumors which developed after an ureterosigmoidostomy. In a checkup, four years after the operation, an inflamed polyp was found in one patient. The second patient developed an adenoma in the section of the colon where the ureter had been implanted. The last patient died of adenocarcinoma of the colon 26 years after her operation. Possible reasons for the development of the tumors, specifically the cancerous ones, are discussed. The risk of developing colon carcinoma is 500 times higher in those who have had an ureterosigmoidostomy than in healthy people. In the case that the ureters are rediverted the section of the colon where they were previously attached must be excised; since there is a strong possibility of cancerous development. To detect the early development of tumors in the colon, we suggest that patients have their stool tested for blood at regular intervals starting 3 years post operatively. If no problems arise barium enema and coloscopy are recommended every five years.

Adenocarcinoma↗
PubMed1982

Comparative evaluation of the effects of tetracycline, rolitetracycline and doxycycline on some blood parameters related to liver function.

A comparative study was made on the effects of tetracycline (TC), rolitetracycline (RTC), and doxycycline (DC) at doses of 10-100 micrograms/g i.v. on serum GOT, GPT, bilirubin and urea levels of male and female mice. All tetracyclines at doses of 50-100 micrograms/g caused an increase of serum GOT and GPT activities in females after 2-8 h. This effect was less pronounced in males. The serum urea levels were markedly raised by TC and DC (50-100 micrograms/g) and RTC (10-100 micrograms/g). This effect was produced only in females. It was long-lasting (up to 8 h) after TC and RTC and more transient after DC. Likewise the tetracyclines affected the serum bilirubin only in females but not in males. All tetracyclines (25-100 micrograms/g) increased the amount of unconjugated and total bilirubin. This effect was most pronounced after TC, which also reduced the level of conjugated bilirubin.

Alanine Transaminase↗
PubMed1981

Age dependency of rolitetracycline-induced hepatic steatosis.

A comparative study on the effect of rolitetracycline (50 micrograms/g i.v.) on the hepatic content of triglycerides and the release of esterified fatty acids from the liver into the blood was performed in young and adult NMRI mice of both sexes. Rolitetracycline caused an accumulation of triglycerides only in the livers of adult animals, the effect being much more pronounced in females than in males. In agreement with this a very strong inhibition of lipid release from the liver and a significant decrease of the esterified fatty acids of the serum was produced only in adult females. The results suggest that the livers of young animals of both sexes are relatively resistant to the steatotic effect of rolitetracycline.

Age Factors↗
PubMed1981

[Experience with "internal and external urinary diversion" in operative treatment of renal and ureteral stones (author's transl)].

Experience and findings with internal and external urinary diversion in surgery of renal and ureteral stones are presented. The benefits of internal intubation of the ureter (endoprosthesis) with plastic tubes (PVC-tubes) as used in our clinic are emphasized. In contrast to nephrostomy with the endoprosthesis is a non-traumatic method, few complications and good results.

Humans↗
PubMed1981

Comparison of distribution of doxycycline in mice after oral and intravenous application measured by a high-performance liquid chromatographic method.

Doxycycline levels in various organs of mice after i.v. and p.o. administration were measured by a high-performance liquid chromatography method. When given as a single dose (50 mg/kg) i.v. doxycycline accumulated in the lung. High concentrations were also measured in liver and kidneys. When 50 mg/kg doxycycline were administered by stomach tube to fed mice the antibiotic accumulated to a lesser degree in the lung. On the other hand, the antibiotic levels in the liver and the kidneys were higher as after i.v. injection. The absorption of doxycycline administered p.o. was about 92% and seemed not to be influenced by food in the stomach. The elimination half-life in mice was 170 min independent of the route of administration.

Administration, Oral↗
PubMed1981

Comparative evaluation of the effects of tetracycline and doxycycline on blood and liver lipids on male and female mice.

The effects of tetracycline and doxycycline (10-100 mg/g i.v.) on the triglyceride and cholesterol contents of liver and blood were studied comparatively in male and female mice. Only tetracycline increased the triglyceride content of the liver. The cholesterol content of the liver was raised by both tetracycline and doxycycline. Tetracycline and doxycycline increased the concentration of unesterified cholesterol and decreased esterified and total cholesterol in the serum. Most effects were more consistent or more pronounced in females than in males.

Animals↗