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Biomedical subjects

R Beckert

Publications and source records attributed to R Beckert.

36 records · Page 2Linked to original sources
PubMed1986

[Insulin and glucagon secretion of the preserved dog pancreas].

Well defined results can be obtained quickly by in vitro test concerning the preservation effect of the preserved dog's pancreas. Clinical and chemical parameters were received during the hypothermic perfusion respectively during the refrigerant storage. The in vitro function tests were carried out after the preservation by insulin and glucagon stimulation. The results showed that the A and B cells of the dog's pancreas are completely able to function after a preservation of 24 hours. Thereby a strong formation of edemas by releasing high enzyme activities is caused during the mechanical perfusion of the organs. The simple refrigerant storage of the pancreata therefore, is the more suitable preservation form for organ transplantations.

Animals↗
PubMed1986

[Preliminary results of the treatment of erectile impotence by intracavernous self administration of vasoactive substances].

From a group of 120 patients with erectile deficiency, 43 cases with arterial disorders with or without associated nervous, psychologic or venous causes were selected for treatment. Mean age of group was 44.5 years. A preliminary series of test was performed during hospital stay, consisting of injection of phentolamine and papaverine into corpus cavernosum. This allowed determination of the minimal effective dose for maintaining erection, and 41 patients accepted to continue treatment at home by auto-injection of products. Regular review showed that all had erections, considered to be complete in 95%. The initially determined dose was usually reduced, probably due to sexual stimulation. The erections appeared earlier (8 min) and lasted longer (140 min), ejaculation provoking only minimal detumescence. Patients responding poorly had venous losses. During initial tests, 2 patients had abnormally prolonged erections requiring puncture of corpus cavernosum. Incidents or habit-forming did not develop and patients and partners did not present psychological problems.

Adult↗
PubMed1985

Clinical course in insulin-dependent diabetics undergoing hemodialysis.

Nephropathy continues to be the most serious complication in type I-diabetics. When we started chronic hemodialysis in these patients 15 years ago survival figures were poor. Later on the survival rate for diabetics undergoing hemodialysis has improved progressively. The aim of this report was to present our own experience in hemodialysis treatment of insulin-dependent diabetics. The cumulative survival rate of 46 insulin-dependent diabetics undergoing hemodialysis has increased progressively and now amounts to 70% after one year, and 50% after two years of treatment. At the same time we could attain a certain improvement of metabolic control. Nutrition has also been improved, as indicated by increased transferrin (p less than 0.05) and stable serum protein levels. Systolic blood pressure control became better (p less than 0.05) but, a fluid overload was still present. Here, further improvements are necessary to increase the survival rate. Therefore, the survival of diabetic patients with hemodialysis may be approaching that of non-diabetics. In some patients retinopathy was improved after one year of treatment. Despite a better prognosis for survival in diabetics treated by chronic hemodialysis we suggest that the successful renal transplantation should be the treatment of choice in patients suffering from diabetic nephropathy. In general, hemodialysis and renal transplantation should be started earlier than hitherto, i.e. already at creatinine levels of about 600 mumol/l, and at urea levels of 30 mmol/l. Strict metabolic and blood pressure control, as well as early laser coagulation therapy of retinopathy should be instituted for patients with creatine levels above 200 mumol/l, in close cooperation of a diabetologist, nephrologist, and ophthalmologist. This will be our future therapeutic strategy for these patients.

Adult↗
PubMed1983

Enhanced synthesis, storage, and secretion of insulin in pancreatic islets derived from obese subjects.

Insulin biosynthesis, content, and secretion were investigated in islets derived from pancreas specimens of normal weight (100.4 +/- 1.1% of ideal body weight) and obese (137.2 +/- 5.9% of ideal weight) patients. The pancreatic islets from the obese subjects were characterized by a significantly enhanced glucose-induced insulin secretion and biosynthesis and by an insulin content that was nearly double when compared with islets from the nonobese subjects. The results support the hypothesis that an enhanced beta-cell reactivity significantly contributes to the insulin hyperresponse observed in the obese state.

Adult↗
PubMed1981

[Therapy of posttraumatic osteomyelitis. Present state (author's transl)].

Between 1977 and 1979 a total of 79 patients with osteomyelitis were seen at the Surgical Dept. of the Greifswald-University. 144 operations were performed, 93 to cure infections, 17 for stabilisation of bones (preferably by "Fixateur externe", 34 for closure of bone and soft tissue defects. Special attention is devoted to transplantation of autologous cancellous bone chips, crossleg-flaps and splitskin grafts for secondary wound cover.

Bone Transplantation↗
PubMed1977

[Histological and immunohistochemical investigations on the transplanted isolated islets of Langerhans in diabetic rats (author's transl)].

Isologous isolated islets of LANGERHANS were transplanted in the peritoneum and through the portal vein in the liver of diabetic rats. With the help of histological and immunohistochemical investigations, estimation of blood sugar and glucose tolerance tests was tested over a period of 12 month, whether the peritoneum or the liver is more suited as transplantation site for isolated islets of LANGERHANS. After transplantation of islets of LANGERHANS in the peritoneum of diabetic rats the blood glucose decreased and this effect could be maintained over a period of three months. The histological investigations showed strong periinsulinar reactions and the immunohistochemical insulin and glucagon proofs prospered over a period of three months. After transplantation of isolated islets in the liver it resulted in a normalization of blood glucose levels up to 12 months after transplantation and in this time prospered the immunohistochemical insulin and glucagon proof. These results have suggested, that the liver is more suited as transplantation site for isolated islets of LANGERHANS than the peritoneum.

Animals↗
PubMed1977

[Experimental studies on the domestic pig about reconstruction of the injured organ of continence].

In 12 domestic pigs, body weight ranging between 30 and 40 kg at operation, under general anesthesia the continence organ was paracoccygeally dissected on one side, and in 6 other animals bilaterally, and immediately thereafter reconstructed. The reconstruction was done paying regard to the fascial skeleton. In all cases the wounds healed primarily. The functional results were good, incontinence was not observed.

Animals↗
PubMed1976

[Transplantation of isolated islets of Langerhans into the liver of diabetic dogs (author's transl)].

Isolated islets of Langerhans were transplanted through the portal vein in the liver of 8 diabetic dogs; In 4 dogs a homologous transplantation was performed and another group of four dogs received isolated islets from their sisters or brothers. In both groups, there was an immediate effect on the blood glucose level. After pancreatectomy and injection of Alloxan the blood glucose rose to between 350 and 420 mg per 100 ml and after islet implantation the blood glucose decreased between 80 to 160 mg per 100 ml. The iv GTT'S were after islet implantation clear better than in the diabetic control animals. These results could maintained in the recipients with homologues islets over a period of 6 to 8 weeks and in the other group of dogs over a period of 6 to 12 months. We were able to show, that the islet implantation in the liver of diabetic dogs did not disturb the microscopic architecture of the liver. No signs of portal hypertension, hepatic congestion and embolism were found.

Animals↗
PubMedDate not supplied

Transplantation of isologous islets of Langerhans in diabetic rats.

Isologous isolated islets of Langerhans were transplanted into the peritoneum and, via the portal vein, into the liver of diabetic rats. In both groups almost normal blood glucose and serum insulin levels were achieved for a period of three months. Glucose tolerance tests were markedly improved. Morphological examination of the transplanted islets and immunohistochemical tests for insulin and glucagon showed the liver to be a more suitable site for islet grafting than the peritoneum.

Animals↗
PubMedDate not supplied

[Urologic monitoring of children with meningomyelocele].

In addition to neuropediatrical, neurosurgical and orthopedical care a continuous urological surveillance is indicated in children with myelodysplasia. Urodynamic assessment, voiding cystourethrography, kidney- and residual urine, ultrasound, excretory urography and radioisotope studies at birth and periodically until puberty are performed to evaluate the urinary tract. Early and specific treatment of bladder dysfunction is necessary to prevent urinary infection and preserve renal parenchyma. Urodynamic testing showed evidence of neurogenic bladder dysfunction in 13 of 14 evaluated children (including 8 newborns): detrusor-sphinkter-dyssynergia in 57 percent, detrusor hyperreflexia in 21 percent and detrusor areflexia in 14 percent. 4 of 5 children with detrusor-sphkincter-dyssynergia were treated effectively with anticholinergic agents and clean intermittend catheterization.

Adolescent↗