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Biomedical subjects

R Bertolini

Publications and source records attributed to R Bertolini.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Problems in reconstruction of digestive continuity in demolition surgery of the stomach].

The commonest stomach demolition techniques and the chances of re-establishing digestive continuity following gastric exersis are examined. The physiological consequences of gastric surgery - gastric, pancreatic and biliary consequences - are discussed. After analysing general and specific operating complications, early and late postoperative complications and general and metabolic complications, the paper closed with a presentation of the results of a reassessment of 1415 gastroduodenostomies carried out using the same technique over a period of eight years by three teams directed and controlled directly or indirectly by Prof. G. Brancadoro.

Dumping Syndrome↗
PubMed1980

[Prenatal development of connective and supportive tissue in the inferior nasal concha of man].

At histological sections of 16 human noses from the 3rd fetal month up to the newborn stage the continuous increase of collagen structures in the connective and holding tissue aging of the inferior nasal concha were investigated with conventional histological, polarisationsoptical and histochemical technics. It was stated that from the 3rd up to the 5th fetal month a mesenchyme in the process of changing is present and in the 5th fetal month a fibre texture like in adults can be seen. The ossification of the chondral frame work of the concha to a double lamella begins in the 5th fetal month, but isn't completely finished in the newborn. The concentration of neutral polysaccharides and glycosaminoglycanes increases with the onset of fiber formation and ossification.

Cartilage↗
PubMed1976

[Growth and aging of connective tissue].

The organs and organ systems of neonates usually show a differently advanced development of connective tissue. This must be considered when determining the change caused by ageing in specific connective tissue structures, especially if it is desired to establish relations between structure, function and time. In those organs which assume important functions during or immediately after birth the connective tissue components are more highly developed than in those which, after birth, are not subject to full functional strains. This particular phenomenon has been demonstrated by specific examples.

Adaptation, Biological↗
PubMed1976

[The influence of the N-mustard derivative "cytostasan" on pregnancy and fetal development in the rat].

This presentation describes the action of Cytostasan, a nitrogen mustard compound of benzimidazole, on reproduction and embryonic development of Wistar rats. Single doses from 20 through 100 mg/kg body weight were given intraperitoneally on the 4th, 7th, 9th, 11th or 13th day post coitum. All test animals were sacrificed on the 20th day of pregnancy. The following parameters served as a base for evaluation: the means of implantation rates, resorption rates, fetal body weights and the number of dead and living fetuses. Malformations were detected by outer inspection for gross anomalies, by means of the razor blade technique for malformations of organs and by alizarin preparations for detecting anomalies of the osseuos skeleton. All results were compared with those of an untreated control group and evaluated by statistical means. Cytostasan exerts embryotoxic and teratogenic effects in appropriate dosage. Notwithstanding the fact of giving high doses (1/2 LD 50) there is no loss of blastocysts before implantation: the number of implantation sites equals that of the control group. The resorption rate increases at all examined days of development after application of 40 mg/kg, but 20 mg/kg exert effects only on days 4, 7, and 11 p. c. There is no action on the number of living fetuses after injection of 20 mg Cytostasan/kg body weight. After application of 40 mg/kg the number of living fetuses decreases especially on the 7th, 9th, and 13th day p. c. There is a dose-dependent stunting: the fetal body weight is not reduced after a dosage of 20 mg/kg, but 40 mg/kg cause a considerable loss of weight during embryogenesis (days 9, 11, 13). It is impossible to induce stunting during blastogenesis (days 4 and 7). The observed patterns of malformation are relatively uniform: kinked tails, omphaloceles, hydronephroses, hydrocephali. Skeletal defects are absent. The results received are compared with other findings on aklylating antitumour drugs.

Abnormalities, Drug-Induced↗